Ensembl ID ENSG00000168374 Gene ID 378 Accession 655
Gene Symbol ARF4 Alias ARF2 Full Name ADP ribosylation factor 4
Position 3 : 57571363 - 57598220 Length 26858 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

ENSG00000168374 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000168374 0.59 3.34e-33 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000168374 tumor 12472661
ENSG00000168374 breast cancer 22004728
ENSG00000168374 epithelial ovarian cancer 28057486
ENSG00000168374 tumor 28445515
ENSG00000168374 breast cancer 29249802
ENSG00000168374 thyroid cancer 31672844
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000168374 MESO 0.00016 high
ENSG00000168374 SARC 0.0043 high
ENSG00000168374 STAD 0.031 high
ENSG00000168374 UVM 0.0082 low
ENSG00000168374 PAAD 0.0091 high
ENSG00000168374 THCA 0.00015 high
ENSG00000168374 HNSC 0.047 high
ENSG00000168374 KIRP 0.013 high
ENSG00000168374 KICH 0.016 high
ENSG00000168374 PCPG 0.0013 low
ENSG00000168374 BRCA 0.013 high
ENSG00000168374 COAD 0.017 low
ENSG00000168374 DLBC 0.029 low
ENSG00000168374 KIRC 0.0021 low
ENSG00000168374 PRAD 0.012 high
ENSG00000168374 BLCA 0.0076 high
ENSG00000168374 LAML 0.012 low
ENSG00000168374 SKCM 0.034 low
ENSG00000168374 CESC 0.013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000168374 LUSC Del 5.160097 0.114748 0.417470 0.864271
ENSG00000168374 LUAD Del 0.697400 0.050985 0.324991 0.463178
ENSG00000168374 CESC Del 3.154499 0.107531 0.547966 0.433898
ENSG00000168374 COAD Del 1.028011 0.046091 0.423835 0.155211
ENSG00000168374 UCS Del 3.680428 0.405994 0.549597 0.678571
ENSG00000168374 SARC Del 1.228933 0.137332 0.511081 0.252918
ENSG00000168374 ESCA Del 2.020724 0.134154 0.445489 0.684783
ENSG00000168374 HNSC Del 1.512207 0.063673 0.439070 0.718391
ENSG00000168374 LIHC Del 0.674825 0.064666 0.439319 0.183784
ENSG00000168374 BLCA Del 4.923193 0.132943 0.410651 0.279412
ENSG00000168374 BRCA Del 27.929068 0.171219 0.465397 0.310185
ENSG00000168374 STAD Del 2.880260 0.088625 0.329727 0.324263
ENSG00000168374 UCEC Del 3.306674 0.075324 0.523340 0.137291
ENSG00000168374 MESO Del 8.670680 0.363372 0.542481 0.379310
ENSG00000168374 KIRC Del 23.941642 0.109905 0.512564 0.820076