Ensembl ID ENSG00000168298 Gene ID 3008 Accession 4718
Gene Symbol H1-4 Alias H1E;H1.4;H1F4;RMNS;H1s-4;HIST1H1E;dJ221C16.5 Full Name H1.4 linker histone, cluster member
Position 6 : 26156329 - 26157115 Length 787 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

ENSG00000168298 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000168298 1.71 1.79e-15 HNSC
ENSG00000168298 2.53 3.42e-11 BLCA
ENSG00000168298 2.04 1.13e-34 BRCA
ENSG00000168298 3.84 2.34e-22 COAD
ENSG00000168298 -3.9 1.48e-31 KICH
ENSG00000168298 2.31 5.92e-25 LUSC
ENSG00000168298 2.16 1.61e-22 PRAD
ENSG00000168298 2.84 2.50e-23 UCEC
ENSG00000168298 3.75 2.31e-34 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000168298 cancer 11572461
ENSG00000168298 tumor 23308215
ENSG00000168298 tumour 26171933
ENSG00000168298 cancer 26209800
ENSG00000168298 Cancer 27531738
ENSG00000168298 breast cancer 29844878
ENSG00000168298 Cancer 30833417
ENSG00000168298 cancer 31221981
ENSG00000168298 AML 31577790
ENSG00000168298 cancer 8551113
ENSG00000168298 tumor 9877246
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000168298 MESO 0.023 high
ENSG00000168298 SARC 0.0016 high
ENSG00000168298 STAD 0.0079 low
ENSG00000168298 THCA 0.00088 high
ENSG00000168298 ACC 0.00014 high
ENSG00000168298 LGG 0.00053 high
ENSG00000168298 HNSC 0.0064 high
ENSG00000168298 READ 0.015 low
ENSG00000168298 KIRP 0.00013 high
ENSG00000168298 KICH 0.023 high
ENSG00000168298 COAD 0.043 high
ENSG00000168298 UCS 0.022 low
ENSG00000168298 ESCA 0.0028 high
ENSG00000168298 TGCT 0.00062 high
ENSG00000168298 BLCA 0.011 low
ENSG00000168298 SKCM 0.015 low
ENSG00000168298 LIHC 0.0079 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000168298 PAAD Del 1.413532 0.060016 0.328655 0.375000
ENSG00000168298 ESCA Del 1.401003 0.116503 0.381049 0.277174
ENSG00000168298 SKCM Amp 2.215015 0.167852 0.743132 0.523161
ENSG00000168298 LIHC Amp 1.361709 0.131059 0.741042 0.408108
ENSG00000168298 BLCA Amp 2.604780 0.227760 0.556097 0.291667
ENSG00000168298 UVM Amp 1.976306 0.243776 1.148270 0.537500
ENSG00000168298 OV Amp 2.173087 0.379759 0.703912 0.469775