Ensembl ID ENSG00000168028 Gene ID 3921 Accession 6502
Gene Symbol RPSA Alias SA;LBP;LRP;p40;uS2;67LR;ICAS;lamR;37LRP;LAMBR;LAMR1;LRP/LR;LBP/p40;NEM/1CHD4 Full Name ribosomal protein SA
Position 3 : 39406720 - 39426255 Length 19536 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000168028 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000168028 RPSA 0.93 4.86e-15 KIRP
ENSG00000168028 RPSA 0.91 5.63e-11 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000168028 RPSA cancer 10066078
ENSG00000168028 RPSA cancer 10363581
ENSG00000168028 RPSA cancer 10376960
ENSG00000168028 RPSA tumors 10389934
ENSG00000168028 RPSA breast cancer 10683318
ENSG00000168028 RPSA cancer 10779645
ENSG00000168028 RPSA cancer 11752855
ENSG00000168028 RPSA tumor 11888899
ENSG00000168028 RPSA gastric cancer 12440778
ENSG00000168028 RPSA tumors 12875970
ENSG00000168028 RPSA lung cancer 1306245
ENSG00000168028 RPSA small cell lung cancer 1310392
ENSG00000168028 RPSA lung cancer 1314918
ENSG00000168028 RPSA breast-cancer 1399148
ENSG00000168028 RPSA tumor 14603723
ENSG00000168028 RPSA tumour 14612903
ENSG00000168028 RPSA tumors 14614142
ENSG00000168028 RPSA tumors 14663356
ENSG00000168028 RPSA tumors 14669791
ENSG00000168028 RPSA cancer 15024383
ENSG00000168028 RPSA malignant skin tumors 1533815
ENSG00000168028 RPSA lung cancer 1534510
ENSG00000168028 RPSA tumor 15368589
ENSG00000168028 RPSA tumors 15890231
ENSG00000168028 RPSA cancer 15946191
ENSG00000168028 RPSA tumor 15947111
ENSG00000168028 RPSA cancer 16140266
ENSG00000168028 RPSA cancer 16416476
ENSG00000168028 RPSA metastatic tumor 16481804
ENSG00000168028 RPSA cervical cancer 16514834
ENSG00000168028 RPSA tumor 16788104
ENSG00000168028 RPSA tumors 16818948
ENSG00000168028 RPSA cancers 16973587
ENSG00000168028 RPSA gastric cancer 17476462
ENSG00000168028 RPSA cancer 17535553
ENSG00000168028 RPSA cancer 17904921
ENSG00000168028 RPSA tumor 17928039
ENSG00000168028 RPSA esophageal cancer 17960614
ENSG00000168028 RPSA tumor 18063583
ENSG00000168028 RPSA tumor 18079119
ENSG00000168028 RPSA cancer 18387633
ENSG00000168028 RPSA colon cancer 18423375
ENSG00000168028 RPSA lung cancer 18794547
ENSG00000168028 RPSA gastric cancers 19123465
ENSG00000168028 RPSA tumor 19182490
ENSG00000168028 RPSA metastatic cancer 19196078
ENSG00000168028 RPSA cancer 19200017
ENSG00000168028 RPSA cancer 19367120
ENSG00000168028 RPSA tumor 19446013
ENSG00000168028 RPSA tumors 19481788
ENSG00000168028 RPSA cancer 19544211
ENSG00000168028 RPSA cancers 19638980
ENSG00000168028 RPSA breast-cancer 19691449
ENSG00000168028 RPSA metastatic tumor 19950927
ENSG00000168028 RPSA gastric cancer 19998339
ENSG00000168028 RPSA tumor 20061812
ENSG00000168028 RPSA AML 20096012
ENSG00000168028 RPSA cancer 20233419
ENSG00000168028 RPSA gastric cancer 20491781
ENSG00000168028 RPSA metastatic cancer 20515747
ENSG00000168028 RPSA tumor 20548792
ENSG00000168028 RPSA tumor 21040730
ENSG00000168028 RPSA cancer 21110766
ENSG00000168028 RPSA ovarian cancer 21193558
ENSG00000168028 RPSA cancers 21249134
ENSG00000168028 RPSA cancer 21422740
ENSG00000168028 RPSA tumor 21838916
ENSG00000168028 RPSA cancers 21895963
ENSG00000168028 RPSA tumor 22285843
ENSG00000168028 RPSA tumor 22290616
ENSG00000168028 RPSA prostate cancer 22391421
ENSG00000168028 RPSA cancer 22666419
ENSG00000168028 RPSA cancer 22751010
ENSG00000168028 RPSA tumor 22847302
ENSG00000168028 RPSA cancer 22884420
ENSG00000168028 RPSA colorectal cancer 22959209
ENSG00000168028 RPSA tumor 22964639
ENSG00000168028 RPSA cancer 23042000
ENSG00000168028 RPSA tumor 23111328
ENSG00000168028 RPSA cancer 23137297
ENSG00000168028 RPSA cancer 23249430
ENSG00000168028 RPSA cancer 23348734
ENSG00000168028 RPSA cancer 23348740
ENSG00000168028 RPSA lung cancer 23374247
ENSG00000168028 RPSA cervical cancer 23472084
ENSG00000168028 RPSA tumour 23554951
ENSG00000168028 RPSA Cancer 23823499
ENSG00000168028 RPSA cervical cancer 23990477
ENSG00000168028 RPSA colorectal cancer 23991217
ENSG00000168028 RPSA cancer 24212136
ENSG00000168028 RPSA cancers 24284829
ENSG00000168028 RPSA colorectal cancer 24460263
ENSG00000168028 RPSA cancer 24494192
ENSG00000168028 RPSA gastric cancer 24703465
ENSG00000168028 RPSA tumor 24706505
ENSG00000168028 RPSA lung cancer 24722356
ENSG00000168028 RPSA Liver Cancer 24798101
ENSG00000168028 RPSA Gastric cancer 24840404
ENSG00000168028 RPSA cancer 24953562
ENSG00000168028 RPSA cancer 24983501
ENSG00000168028 RPSA gastric cancer 25060631
ENSG00000168028 RPSA tumor 25153908
ENSG00000168028 RPSA cancer 25274119
ENSG00000168028 RPSA tumor 25294877
ENSG00000168028 RPSA cancer 25747044
ENSG00000168028 RPSA tumor 25778325
ENSG00000168028 RPSA cancer 25824377
ENSG00000168028 RPSA cancer 26018505
ENSG00000168028 RPSA tumor 26062445
ENSG00000168028 RPSA cancer 26135316
ENSG00000168028 RPSA metastatic cancer 26146125
ENSG00000168028 RPSA cancer 26264277
ENSG00000168028 RPSA colon cancer 26293895
ENSG00000168028 RPSA Cancer 26427016
ENSG00000168028 RPSA cancer 26545108
ENSG00000168028 RPSA tumor 26603095
ENSG00000168028 RPSA cancer 26670257
ENSG00000168028 RPSA breast cancer 26694341
ENSG00000168028 RPSA tumor 26754091
ENSG00000168028 RPSA tumor 27278998
ENSG00000168028 RPSA breast cancer 27611822
ENSG00000168028 RPSA cancer 27663887
ENSG00000168028 RPSA tumor 27748570
ENSG00000168028 RPSA pancreatic cancer 27884119
ENSG00000168028 RPSA tumors 27896222
ENSG00000168028 RPSA cancer 28118986
ENSG00000168028 RPSA cancer 28147343
ENSG00000168028 RPSA cancer 28507327
ENSG00000168028 RPSA cancer 28618937
ENSG00000168028 RPSA Cancer 28699539
ENSG00000168028 RPSA cancer 28798484
ENSG00000168028 RPSA breast cancer 28827731
ENSG00000168028 RPSA pancreatic cancer 28899658
ENSG00000168028 RPSA gastric cancer 29069734
ENSG00000168028 RPSA tumor 29140585
ENSG00000168028 RPSA cancer 29156824
ENSG00000168028 RPSA tumor 29486285
ENSG00000168028 RPSA tumor 29653110
ENSG00000168028 RPSA cancer 29843646
ENSG00000168028 RPSA tumor 29867512
ENSG00000168028 RPSA endometrial cancer 30028353
ENSG00000168028 RPSA cervical cancer 30208169
ENSG00000168028 RPSA cancer 30213077
ENSG00000168028 RPSA tumor 30213130
ENSG00000168028 RPSA tumour 30563268
ENSG00000168028 RPSA tumor 30585192
ENSG00000168028 RPSA cancer 30739912
ENSG00000168028 RPSA pancreatic cancer 30894280
ENSG00000168028 RPSA tumor 31139235
ENSG00000168028 RPSA cancer 31722579
ENSG00000168028 RPSA cancer 31749945
ENSG00000168028 RPSA ovarian cancer 7654437
ENSG00000168028 RPSA cancers 7695618
ENSG00000168028 RPSA cancer 7827956
ENSG00000168028 RPSA breast cancer 7860133
ENSG00000168028 RPSA tumour 7911032
ENSG00000168028 RPSA cancer 8198600
ENSG00000168028 RPSA cancer 8257781
ENSG00000168028 RPSA tumors 8344742
ENSG00000168028 RPSA breast cancer 8472397
ENSG00000168028 RPSA cancer 8655633
ENSG00000168028 RPSA colorectal cancer 8773262
ENSG00000168028 RPSA tumor 8814988
ENSG00000168028 RPSA breast cancer 8824265
ENSG00000168028 RPSA tumours 8869283
ENSG00000168028 RPSA colorectal cancer 8893333
ENSG00000168028 RPSA tumours 8911124
ENSG00000168028 RPSA ovarian cancer 8912829
ENSG00000168028 RPSA cancer 8940117
ENSG00000168028 RPSA cancer 8985115
ENSG00000168028 RPSA cancer 9155714
ENSG00000168028 RPSA tumor 9176710
ENSG00000168028 RPSA cancer 9182288
ENSG00000168028 RPSA cancers 9218732
ENSG00000168028 RPSA tumours 9227340
ENSG00000168028 RPSA colon cancer 9459140
ENSG00000168028 RPSA tumor 9581863
ENSG00000168028 RPSA gastric cancer 9732225
ENSG00000168028 RPSA gastric cancer 9734182
ENSG00000168028 RPSA non-small cell lung cancer 9815677
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000168028 RPSA SARC 0.039 high
ENSG00000168028 RPSA CHOL 0.019 high
ENSG00000168028 RPSA UCEC 0.036 low
ENSG00000168028 RPSA ACC 0.00064 high
ENSG00000168028 RPSA KIRP 0.0061 high
ENSG00000168028 RPSA PCPG 0.042 low
ENSG00000168028 RPSA THYM 0.00023 low
ENSG00000168028 RPSA BRCA 0.0026 low
ENSG00000168028 RPSA DLBC 0.034 low
ENSG00000168028 RPSA LIHC 0.0079 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000168028 RPSA BRCA Del 6.512105 0.100045 0.437348 0.259259
ENSG00000168028 RPSA STAD Del 2.019683 0.078805 0.331420 0.308390
ENSG00000168028 RPSA MESO Del 6.265430 0.302395 0.562852 0.310345
ENSG00000168028 RPSA KIRC Del 51.122324 0.180647 0.516538 0.880682