Ensembl ID
ENSG00000168028
Gene ID
3921
Accession
6502
Gene Symbol
RPSA
Alias
SA;LBP;LRP;p40;uS2;67LR;ICAS;lamR;37LRP;LAMBR;LAMR1;LRP/LR;LBP/p40;NEM/1CHD4
Full Name
ribosomal protein SA
Position
3 : 39406720 - 39426255
Length
19536 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs rRNA RBP type
Canonical_RBPs
Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
ENSG00000168028 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000168028
RPSA
0.93
4.86e-15
KIRP
ENSG00000168028
RPSA
0.91
5.63e-11
LIHC
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000168028
RPSA
cancer
10066078
ENSG00000168028
RPSA
cancer
10363581
ENSG00000168028
RPSA
cancer
10376960
ENSG00000168028
RPSA
tumors
10389934
ENSG00000168028
RPSA
breast cancer
10683318
ENSG00000168028
RPSA
cancer
10779645
ENSG00000168028
RPSA
cancer
11752855
ENSG00000168028
RPSA
tumor
11888899
ENSG00000168028
RPSA
gastric cancer
12440778
ENSG00000168028
RPSA
tumors
12875970
ENSG00000168028
RPSA
lung cancer
1306245
ENSG00000168028
RPSA
small cell lung cancer
1310392
ENSG00000168028
RPSA
lung cancer
1314918
ENSG00000168028
RPSA
breast-cancer
1399148
ENSG00000168028
RPSA
tumor
14603723
ENSG00000168028
RPSA
tumour
14612903
ENSG00000168028
RPSA
tumors
14614142
ENSG00000168028
RPSA
tumors
14663356
ENSG00000168028
RPSA
tumors
14669791
ENSG00000168028
RPSA
cancer
15024383
ENSG00000168028
RPSA
malignant skin tumors
1533815
ENSG00000168028
RPSA
lung cancer
1534510
ENSG00000168028
RPSA
tumor
15368589
ENSG00000168028
RPSA
tumors
15890231
ENSG00000168028
RPSA
cancer
15946191
ENSG00000168028
RPSA
tumor
15947111
ENSG00000168028
RPSA
cancer
16140266
ENSG00000168028
RPSA
cancer
16416476
ENSG00000168028
RPSA
metastatic tumor
16481804
ENSG00000168028
RPSA
cervical cancer
16514834
ENSG00000168028
RPSA
tumor
16788104
ENSG00000168028
RPSA
tumors
16818948
ENSG00000168028
RPSA
cancers
16973587
ENSG00000168028
RPSA
gastric cancer
17476462
ENSG00000168028
RPSA
cancer
17535553
ENSG00000168028
RPSA
cancer
17904921
ENSG00000168028
RPSA
tumor
17928039
ENSG00000168028
RPSA
esophageal cancer
17960614
ENSG00000168028
RPSA
tumor
18063583
ENSG00000168028
RPSA
tumor
18079119
ENSG00000168028
RPSA
cancer
18387633
ENSG00000168028
RPSA
colon cancer
18423375
ENSG00000168028
RPSA
lung cancer
18794547
ENSG00000168028
RPSA
gastric cancers
19123465
ENSG00000168028
RPSA
tumor
19182490
ENSG00000168028
RPSA
metastatic cancer
19196078
ENSG00000168028
RPSA
cancer
19200017
ENSG00000168028
RPSA
cancer
19367120
ENSG00000168028
RPSA
tumor
19446013
ENSG00000168028
RPSA
tumors
19481788
ENSG00000168028
RPSA
cancer
19544211
ENSG00000168028
RPSA
cancers
19638980
ENSG00000168028
RPSA
breast-cancer
19691449
ENSG00000168028
RPSA
metastatic tumor
19950927
ENSG00000168028
RPSA
gastric cancer
19998339
ENSG00000168028
RPSA
tumor
20061812
ENSG00000168028
RPSA
AML
20096012
ENSG00000168028
RPSA
cancer
20233419
ENSG00000168028
RPSA
gastric cancer
20491781
ENSG00000168028
RPSA
metastatic cancer
20515747
ENSG00000168028
RPSA
tumor
20548792
ENSG00000168028
RPSA
tumor
21040730
ENSG00000168028
RPSA
cancer
21110766
ENSG00000168028
RPSA
ovarian cancer
21193558
ENSG00000168028
RPSA
cancers
21249134
ENSG00000168028
RPSA
cancer
21422740
ENSG00000168028
RPSA
tumor
21838916
ENSG00000168028
RPSA
cancers
21895963
ENSG00000168028
RPSA
tumor
22285843
ENSG00000168028
RPSA
tumor
22290616
ENSG00000168028
RPSA
prostate cancer
22391421
ENSG00000168028
RPSA
cancer
22666419
ENSG00000168028
RPSA
cancer
22751010
ENSG00000168028
RPSA
tumor
22847302
ENSG00000168028
RPSA
cancer
22884420
ENSG00000168028
RPSA
colorectal cancer
22959209
ENSG00000168028
RPSA
tumor
22964639
ENSG00000168028
RPSA
cancer
23042000
ENSG00000168028
RPSA
tumor
23111328
ENSG00000168028
RPSA
cancer
23137297
ENSG00000168028
RPSA
cancer
23249430
ENSG00000168028
RPSA
cancer
23348734
ENSG00000168028
RPSA
cancer
23348740
ENSG00000168028
RPSA
lung cancer
23374247
ENSG00000168028
RPSA
cervical cancer
23472084
ENSG00000168028
RPSA
tumour
23554951
ENSG00000168028
RPSA
Cancer
23823499
ENSG00000168028
RPSA
cervical cancer
23990477
ENSG00000168028
RPSA
colorectal cancer
23991217
ENSG00000168028
RPSA
cancer
24212136
ENSG00000168028
RPSA
cancers
24284829
ENSG00000168028
RPSA
colorectal cancer
24460263
ENSG00000168028
RPSA
cancer
24494192
ENSG00000168028
RPSA
gastric cancer
24703465
ENSG00000168028
RPSA
tumor
24706505
ENSG00000168028
RPSA
lung cancer
24722356
ENSG00000168028
RPSA
Liver Cancer
24798101
ENSG00000168028
RPSA
Gastric cancer
24840404
ENSG00000168028
RPSA
cancer
24953562
ENSG00000168028
RPSA
cancer
24983501
ENSG00000168028
RPSA
gastric cancer
25060631
ENSG00000168028
RPSA
tumor
25153908
ENSG00000168028
RPSA
cancer
25274119
ENSG00000168028
RPSA
tumor
25294877
ENSG00000168028
RPSA
cancer
25747044
ENSG00000168028
RPSA
tumor
25778325
ENSG00000168028
RPSA
cancer
25824377
ENSG00000168028
RPSA
cancer
26018505
ENSG00000168028
RPSA
tumor
26062445
ENSG00000168028
RPSA
cancer
26135316
ENSG00000168028
RPSA
metastatic cancer
26146125
ENSG00000168028
RPSA
cancer
26264277
ENSG00000168028
RPSA
colon cancer
26293895
ENSG00000168028
RPSA
Cancer
26427016
ENSG00000168028
RPSA
cancer
26545108
ENSG00000168028
RPSA
tumor
26603095
ENSG00000168028
RPSA
cancer
26670257
ENSG00000168028
RPSA
breast cancer
26694341
ENSG00000168028
RPSA
tumor
26754091
ENSG00000168028
RPSA
tumor
27278998
ENSG00000168028
RPSA
breast cancer
27611822
ENSG00000168028
RPSA
cancer
27663887
ENSG00000168028
RPSA
tumor
27748570
ENSG00000168028
RPSA
pancreatic cancer
27884119
ENSG00000168028
RPSA
tumors
27896222
ENSG00000168028
RPSA
cancer
28118986
ENSG00000168028
RPSA
cancer
28147343
ENSG00000168028
RPSA
cancer
28507327
ENSG00000168028
RPSA
cancer
28618937
ENSG00000168028
RPSA
Cancer
28699539
ENSG00000168028
RPSA
cancer
28798484
ENSG00000168028
RPSA
breast cancer
28827731
ENSG00000168028
RPSA
pancreatic cancer
28899658
ENSG00000168028
RPSA
gastric cancer
29069734
ENSG00000168028
RPSA
tumor
29140585
ENSG00000168028
RPSA
cancer
29156824
ENSG00000168028
RPSA
tumor
29486285
ENSG00000168028
RPSA
tumor
29653110
ENSG00000168028
RPSA
cancer
29843646
ENSG00000168028
RPSA
tumor
29867512
ENSG00000168028
RPSA
endometrial cancer
30028353
ENSG00000168028
RPSA
cervical cancer
30208169
ENSG00000168028
RPSA
cancer
30213077
ENSG00000168028
RPSA
tumor
30213130
ENSG00000168028
RPSA
tumour
30563268
ENSG00000168028
RPSA
tumor
30585192
ENSG00000168028
RPSA
cancer
30739912
ENSG00000168028
RPSA
pancreatic cancer
30894280
ENSG00000168028
RPSA
tumor
31139235
ENSG00000168028
RPSA
cancer
31722579
ENSG00000168028
RPSA
cancer
31749945
ENSG00000168028
RPSA
ovarian cancer
7654437
ENSG00000168028
RPSA
cancers
7695618
ENSG00000168028
RPSA
cancer
7827956
ENSG00000168028
RPSA
breast cancer
7860133
ENSG00000168028
RPSA
tumour
7911032
ENSG00000168028
RPSA
cancer
8198600
ENSG00000168028
RPSA
cancer
8257781
ENSG00000168028
RPSA
tumors
8344742
ENSG00000168028
RPSA
breast cancer
8472397
ENSG00000168028
RPSA
cancer
8655633
ENSG00000168028
RPSA
colorectal cancer
8773262
ENSG00000168028
RPSA
tumor
8814988
ENSG00000168028
RPSA
breast cancer
8824265
ENSG00000168028
RPSA
tumours
8869283
ENSG00000168028
RPSA
colorectal cancer
8893333
ENSG00000168028
RPSA
tumours
8911124
ENSG00000168028
RPSA
ovarian cancer
8912829
ENSG00000168028
RPSA
cancer
8940117
ENSG00000168028
RPSA
cancer
8985115
ENSG00000168028
RPSA
cancer
9155714
ENSG00000168028
RPSA
tumor
9176710
ENSG00000168028
RPSA
cancer
9182288
ENSG00000168028
RPSA
cancers
9218732
ENSG00000168028
RPSA
tumours
9227340
ENSG00000168028
RPSA
colon cancer
9459140
ENSG00000168028
RPSA
tumor
9581863
ENSG00000168028
RPSA
gastric cancer
9732225
ENSG00000168028
RPSA
gastric cancer
9734182
ENSG00000168028
RPSA
non-small cell lung cancer
9815677
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000168028
RPSA
SARC
0.039
high
show
ENSG00000168028
RPSA
CHOL
0.019
high
show
ENSG00000168028
RPSA
UCEC
0.036
low
show
ENSG00000168028
RPSA
ACC
0.00064
high
show
ENSG00000168028
RPSA
KIRP
0.0061
high
show
ENSG00000168028
RPSA
PCPG
0.042
low
show
ENSG00000168028
RPSA
THYM
0.00023
low
show
ENSG00000168028
RPSA
BRCA
0.0026
low
show
ENSG00000168028
RPSA
DLBC
0.034
low
show
ENSG00000168028
RPSA
LIHC
0.0079
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000168028
RPSA
BRCA
Del
6.512105
0.100045
0.437348
0.259259
ENSG00000168028
RPSA
STAD
Del
2.019683
0.078805
0.331420
0.308390
ENSG00000168028
RPSA
MESO
Del
6.265430
0.302395
0.562852
0.310345
ENSG00000168028
RPSA
KIRC
Del
51.122324
0.180647
0.516538
0.880682
Copyright © 2023, Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.