Ensembl ID ENSG00000167460 Gene ID 7171 Accession 12013
Gene Symbol TPM4 Alias HEL-S-108 Full Name tropomyosin 4
Position 19 : 16067021 - 16103002 Length 35982 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

ENSG00000167460 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167460 0.56 3.67e-13 COAD
ENSG00000167460 2.12 2.45e-14 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167460 inflammatory myofibroblastic tumors 10934142
ENSG00000167460 cancer 15986332
ENSG00000167460 tumor 16637015
ENSG00000167460 tumor 17131471
ENSG00000167460 ovarian cancer 20349782
ENSG00000167460 cancer 21119665
ENSG00000167460 lung cancer 22347464
ENSG00000167460 lung cancer 22537621
ENSG00000167460 inflammatory myofibroblastic tumor 22614325
ENSG00000167460 inflammatory myofibroblastic tumors 22658521
ENSG00000167460 breast cancer 23594586
ENSG00000167460 ovarian cancer 23792823
ENSG00000167460 tumors 23812729
ENSG00000167460 cancer 25402584
ENSG00000167460 tumors 25770193
ENSG00000167460 tumors 25888090
ENSG00000167460 cancer 26739486
ENSG00000167460 inflammatory myofibroblastic tumor 27013922
ENSG00000167460 cancer 27649540
ENSG00000167460 inflammatory myofibroblastic tumors 28415158
ENSG00000167460 breast cancer 28431393
ENSG00000167460 tumor 29371635
ENSG00000167460 colon cancer 29455030
ENSG00000167460 Cancer 30836651
ENSG00000167460 Cancer 30866497
ENSG00000167460 lung cancer 31239699
ENSG00000167460 gastric cancer 31278140
ENSG00000167460 tumor 31804537
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000167460 Lung Inflammatory Myofibroblastic Tumor gene_fusion 50.0% (4/8) 3 entries
ENSG00000167460 inflammatory myofibroblastic tumor gene_fusion 50.0% (20/40) 5 entries
ENSG00000167460 lung adenocarcinoma missense_variant 0.172% (2/1163) 1 entry
ENSG00000167460 hepatocellular carcinoma missense_variant 0.6674% (6/899) 1 entry
ENSG00000167460 squamous cell lung carcinoma sequence_alteration 0.2625% (2/762) 1 entry
ENSG00000167460 colon adenocarcinoma sequence_alteration 1.218% (9/739) 1 entry
ENSG00000167460 colorectal adenocarcinoma sequence_alteration 0.9666% (11/1138) 1 entry
ENSG00000167460 Liver Inflammatory Myofibroblastic Tumor gene_fusion 50.0% (1/2) 1 entry
ENSG00000167460 prostate carcinoma sequence_alteration 0.7042% (3/426) 1 entry
ENSG00000167460 colon adenocarcinoma missense_variant 1.218% (9/739) 4 entries
ENSG00000167460 skin melanoma missense_variant 0.4137% (4/967) 1 entry
ENSG00000167460 melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000167460 Bladder Inflammatory Myofibroblastic Tumor gene_fusion 50.0% (1/2) 1 entry
ENSG00000167460 esophageal squamous cell carcinoma sequence_alteration 0.2963% (2/675) 1 entry
ENSG00000167460 anaplastic large cell lymphoma gene_fusion 25.0% (1/4) 1 entry
ENSG00000167460 colorectal adenocarcinoma missense_variant 0.9666% (11/1138) 2 entries
ENSG00000167460 Unclassified Renal Cell Carcinoma frameshift_variant 6.667% (1/15) 1 entry
ENSG00000167460 brain glioblastoma sequence_alteration 0.108% (1/926) 1 entry
ENSG00000167460 oral squamous cell carcinoma missense_variant 0.4878% (1/205) 1 entry
ENSG00000167460 prostate carcinoma missense_variant 0.7042% (3/426) 1 entry
ENSG00000167460 diffuse large B-cell lymphoma missense_variant 0.3289% (1/304) 1 entry
ENSG00000167460 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000167460 rectal adenocarcinoma missense_variant 0.4367% (1/229) 1 entry
ENSG00000167460 basal cell carcinoma sequence_alteration 1.724% (1/58) 1 entry
ENSG00000167460 breast ductal adenocarcinoma missense_variant 2.755% (17/617) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167460 MESO 0.00034 high
ENSG00000167460 SARC 0.02 low
ENSG00000167460 STAD 0.031 high
ENSG00000167460 PAAD 0.00024 high
ENSG00000167460 UCEC 0.0059 high
ENSG00000167460 THCA 0.032 high
ENSG00000167460 LUSC 0.028 high
ENSG00000167460 HNSC 0.019 high
ENSG00000167460 LUAD 0.015 high
ENSG00000167460 PCPG 0.00016 high
ENSG00000167460 THYM 0.047 low
ENSG00000167460 COAD 0.0075 low
ENSG00000167460 DLBC 0.00076 high
ENSG00000167460 LAML 0.017 low
ENSG00000167460 CESC 0.016 high
ENSG00000167460 LIHC 0.024 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167460 ACC Amp 1.228562 0.319823 1.092600 0.644444
ENSG00000167460 UCEC Amp 11.700421 0.265960 0.846351 0.185529
ENSG00000167460 OV Amp 28.878879 0.808001 0.945868 0.538860