Ensembl ID ENSG00000167281 Gene ID 146713 Accession 27097
Gene Symbol RBFOX3 Alias FOX3;NEUN;FOX-3;HRNBP3 Full Name RNA binding fox-1 homolog 3
Position 17 : 79089345 - 79611051 Length 521707 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

ENSG00000167281 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167281 -5.2 6.92e-19 BLCA
ENSG00000167281 -4.8 7.28e-52 COAD
ENSG00000167281 -4.1 1.20e-20 KICH
ENSG00000167281 -4.9 5.52e-22 READ
ENSG00000167281 -1.8 5.01e-18 PRAD
ENSG00000167281 -3.5 2.82e-17 UCEC
ENSG00000167281 -6.3 8.21e-14 CESC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167281 Lung Cancer 27432190
ENSG00000167281 lung cancer 28126724
ENSG00000167281 Tumor 28839469
ENSG00000167281 tumor 29480846
ENSG00000167281 Cancer 29689552
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167281 MESO 0.032 high
ENSG00000167281 STAD 0.0092 high
ENSG00000167281 UCEC 0.016 low
ENSG00000167281 THCA 0.0025 high
ENSG00000167281 ACC 0.0071 high
ENSG00000167281 LGG 0.00072 low
ENSG00000167281 READ 0.039 high
ENSG00000167281 LUAD 0.029 high
ENSG00000167281 COAD 0.036 high
ENSG00000167281 ESCA 0.0085 high
ENSG00000167281 TGCT 0.046 high
ENSG00000167281 LAML 3e-04 low
ENSG00000167281 GBM 0.045 high
ENSG00000167281 SKCM 0.045 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167281 LUSC Amp 0.945668 0.202322 0.439949 0.447106
ENSG00000167281 LUAD Amp 3.288406 0.174645 0.402680 0.509690
ENSG00000167281 LGG Amp 2.516991 0.070258 0.513487 0.089669
ENSG00000167281 UCS Amp 1.265780 0.588171 0.787894 0.517857
ENSG00000167281 SKCM Amp 6.392581 0.277321 0.569043 0.351499
ENSG00000167281 LIHC Amp 10.196339 0.291341 0.693865 0.381081
ENSG00000167281 BLCA Amp 2.022256 0.210343 0.459083 0.477941
ENSG00000167281 BRCA Amp 24.086462 0.379899 0.648062 0.370370
ENSG00000167281 UCEC Amp 3.209563 0.154574 0.562619 0.166976
ENSG00000167281 UVM Amp 0.815688 0.175682 0.773563 0.175000
ENSG00000167281 OV Amp 3.698417 0.420933 0.580450 0.359240