Ensembl ID ENSG00000167264 Gene ID 54920 Accession 26014
Gene Symbol DUS2 Alias SMM1;DUS2L;URLC8 Full Name dihydrouridine synthase 2
Position 16 : 67987746 - 68079320 Length 91575 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

ENSG00000167264 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167264 DUS2 0.93 7.35e-23 KICH
ENSG00000167264 DUS2 0.73 2.26e-12 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167264 DUS2 lung cancer 15994936
ENSG00000167264 DUS2 cancer 18096616
ENSG00000167264 DUS2 cancer 26143927
ENSG00000167264 DUS2 lung cancer 28752201
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167264 DUS2 MESO 0.012 high
ENSG00000167264 DUS2 SARC 0.012 high
ENSG00000167264 DUS2 STAD 0.018 low
ENSG00000167264 DUS2 UCEC 0.033 low
ENSG00000167264 DUS2 THCA 0.002 low
ENSG00000167264 DUS2 ACC 0.046 high
ENSG00000167264 DUS2 LGG 0.0084 low
ENSG00000167264 DUS2 HNSC 0.02 high
ENSG00000167264 DUS2 READ 0.048 low
ENSG00000167264 DUS2 KIRP 0.018 low
ENSG00000167264 DUS2 THYM 0.00042 low
ENSG00000167264 DUS2 BRCA 0.0061 high
ENSG00000167264 DUS2 COAD 0.0093 high
ENSG00000167264 DUS2 UCS 0.02 low
ENSG00000167264 DUS2 DLBC 0.003 high
ENSG00000167264 DUS2 KIRC 0.00011 high
ENSG00000167264 DUS2 LAML 0.014 high
ENSG00000167264 DUS2 CESC 0.023 low
ENSG00000167264 DUS2 LIHC 0.0058 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167264 DUS2 LAML Del 2.192563 0.050448 0.635206 0.041885
ENSG00000167264 DUS2 TGCT Amp 1.448869 0.152317 0.674575 0.140000
ENSG00000167264 DUS2 BLCA Amp 1.038867 0.177081 0.486357 0.267157
ENSG00000167264 DUS2 UCEC Del 3.894717 0.080144 0.626542 0.285714
ENSG00000167264 DUS2 OV Del 11.773460 0.316381 0.660792 0.799655