Ensembl ID
ENSG00000167264
Gene ID
54920
Accession
26014
Gene Symbol
DUS2
Alias
SMM1;DUS2L;URLC8
Full Name
dihydrouridine synthase 2
Position
16 : 67987746 - 68079320
Length
91575 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs tRNA RBP type
Canonical_RBPs
Summary
This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
ENSG00000167264 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000167264
DUS2
0.93
7.35e-23
KICH
ENSG00000167264
DUS2
0.73
2.26e-12
KIRP
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000167264
DUS2
lung cancer
15994936
ENSG00000167264
DUS2
cancer
18096616
ENSG00000167264
DUS2
cancer
26143927
ENSG00000167264
DUS2
lung cancer
28752201
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000167264
DUS2
MESO
0.012
high
show
ENSG00000167264
DUS2
SARC
0.012
high
show
ENSG00000167264
DUS2
STAD
0.018
low
show
ENSG00000167264
DUS2
UCEC
0.033
low
show
ENSG00000167264
DUS2
THCA
0.002
low
show
ENSG00000167264
DUS2
ACC
0.046
high
show
ENSG00000167264
DUS2
LGG
0.0084
low
show
ENSG00000167264
DUS2
HNSC
0.02
high
show
ENSG00000167264
DUS2
READ
0.048
low
show
ENSG00000167264
DUS2
KIRP
0.018
low
show
ENSG00000167264
DUS2
THYM
0.00042
low
show
ENSG00000167264
DUS2
BRCA
0.0061
high
show
ENSG00000167264
DUS2
COAD
0.0093
high
show
ENSG00000167264
DUS2
UCS
0.02
low
show
ENSG00000167264
DUS2
DLBC
0.003
high
show
ENSG00000167264
DUS2
KIRC
0.00011
high
show
ENSG00000167264
DUS2
LAML
0.014
high
show
ENSG00000167264
DUS2
CESC
0.023
low
show
ENSG00000167264
DUS2
LIHC
0.0058
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000167264
DUS2
LAML
Del
2.192563
0.050448
0.635206
0.041885
ENSG00000167264
DUS2
TGCT
Amp
1.448869
0.152317
0.674575
0.140000
ENSG00000167264
DUS2
BLCA
Amp
1.038867
0.177081
0.486357
0.267157
ENSG00000167264
DUS2
UCEC
Del
3.894717
0.080144
0.626542
0.285714
ENSG00000167264
DUS2
OV
Del
11.773460
0.316381
0.660792
0.799655
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