Ensembl ID ENSG00000167258 Gene ID 51755 Accession 24224
Gene Symbol CDK12 Alias CRK7;CRKR;CRKRS Full Name cyclin dependent kinase 12
Position 17 : 39461486 - 39551141 Length 89656 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000167258 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167258 0.66 2.35e-11 BRCA
ENSG00000167258 0.56 6.65e-13 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167258 breast cancer 17117180
ENSG00000167258 ovarian cancer 21720365
ENSG00000167258 tumor 22544022
ENSG00000167258 cancers 23613755
ENSG00000167258 tumor 24240700
ENSG00000167258 breast cancers 24395524
ENSG00000167258 Ovarian cancer 24554720
ENSG00000167258 Tumor 25312711
ENSG00000167258 tumor 25429106
ENSG00000167258 tumor 25712099
ENSG00000167258 tumor 26189575
ENSG00000167258 tumors 26622941
ENSG00000167258 Ovarian Cancers 26787835
ENSG00000167258 tumors 27251275
ENSG00000167258 triple-negative breast cancer 27491809
ENSG00000167258 cancer 27571479
ENSG00000167258 Cancer 27601596
ENSG00000167258 ovarian cancer 27642590
ENSG00000167258 cancers 27662623
ENSG00000167258 Triple-Negative Breast Cancer 27880910
ENSG00000167258 lung tumor 27900369
ENSG00000167258 ovarian cancer 27905519
ENSG00000167258 cancer 27935476
ENSG00000167258 lung cancer 28230015
ENSG00000167258 breast cancer 28334900
ENSG00000167258 tumors 28832682
ENSG00000167258 tumor 29025359
ENSG00000167258 breast cancer 29090014
ENSG00000167258 Breast Cancer 29133620
ENSG00000167258 tumor 29338072
ENSG00000167258 Tumor 29358035
ENSG00000167258 tumors 29382369
ENSG00000167258 tumors 29760377
ENSG00000167258 tumor 29872499
ENSG00000167258 Prostate Cancer 29906450
ENSG00000167258 cancers 29992508
ENSG00000167258 tumor 29996110
ENSG00000167258 tumors 30017478
ENSG00000167258 cancers 30062102
ENSG00000167258 cancer 30067358
ENSG00000167258 cancer 30104286
ENSG00000167258 Prostate Cancer 30207914
ENSG00000167258 prostate cancer 30245085
ENSG00000167258 gastric cancer 30310315
ENSG00000167258 tumor 30319007
ENSG00000167258 cancer 30333958
ENSG00000167258 cancers 30409083
ENSG00000167258 ovarian cancer 30422115
ENSG00000167258 tumours 30487607
ENSG00000167258 tumour 30531873
ENSG00000167258 tumor 30541755
ENSG00000167258 tumours 30794536
ENSG00000167258 cancer 30819820
ENSG00000167258 cancer 30988284
ENSG00000167258 Tumor 31040255
ENSG00000167258 prostate cancer 31218271
ENSG00000167258 Breast Cancer 31259151
ENSG00000167258 ovariancancer 31287417
ENSG00000167258 Cancer 31292271
ENSG00000167258 Tumours 31345636
ENSG00000167258 cancer 31347271
ENSG00000167258 tumors 31360735
ENSG00000167258 tumor 31366128
ENSG00000167258 breast tumor 31468695
ENSG00000167258 gastric cancer 31523177
ENSG00000167258 metastatic prostate cancer 31592503
ENSG00000167258 ovarian cancer 31619387
ENSG00000167258 Prostate Cancer 31640893
ENSG00000167258 tumor 31652541
ENSG00000167258 Triple-Negative Breast Cancer 31668947
ENSG00000167258 Triple-Negative Breast Cancer 31676489
ENSG00000167258 Triple-Negative Breast Cancer 31715127
ENSG00000167258 Breast Cancer 31744448
ENSG00000167258 pancreatic cancer 31917448
ENSG00000167258 Prostate cancers 31972048
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000167258 colorectal adenocarcinoma frameshift_variant 4.226% (56/1325) 2 entries
ENSG00000167258 HER2 Positive Breast Carcinoma missense_variant 8.466% (16/189) 2 entries
ENSG00000167258 colon adenocarcinoma frameshift_variant 3.79% (49/1293) 3 entries
ENSG00000167258 colorectal adenocarcinoma conservative_inframe_deletion 4.226% (56/1325) 2 entries
ENSG00000167258 prostate adenocarcinoma missense_variant 4.634% (100/2158) 3 entries
ENSG00000167258 prostate adenocarcinoma frameshift_variant 4.634% (100/2158) 3 entries
ENSG00000167258 colorectal adenocarcinoma sequence_alteration 4.226% (56/1325) 2 entries
ENSG00000167258 colon adenocarcinoma stop_gained 3.79% (49/1293) 2 entries
ENSG00000167258 prostate adenocarcinoma amino_acid_insertion 4.634% (100/2158) 1 entry
ENSG00000167258 prostate adenocarcinoma sequence_alteration 4.634% (100/2158) 2 entries
ENSG00000167258 colorectal adenocarcinoma missense_variant 4.226% (56/1325) 3 entries
ENSG00000167258 colon adenocarcinoma missense_variant 3.79% (49/1293) 6 entries
ENSG00000167258 prostate adenocarcinoma stop_gained 4.634% (100/2158) 2 entries
ENSG00000167258 ovarian serous adenocarcinoma stop_gained 2.086% (19/911) 2 entries
ENSG00000167258 brain glioblastoma sequence_alteration 0.9076% (11/1212) 1 entry
ENSG00000167258 prostate carcinoma stop_gained 3.512% (17/484) 1 entry
ENSG00000167258 colorectal adenocarcinoma amino_acid_insertion 4.226% (56/1325) 1 entry
ENSG00000167258 clear cell renal carcinoma missense_variant 0.6766% (10/1478) 2 entries
ENSG00000167258 esophageal squamous cell carcinoma stop_gained 1.895% (13/686) 3 entries
ENSG00000167258 prostate adenocarcinoma conservative_inframe_deletion 4.634% (100/2158) 1 entry
ENSG00000167258 pancreatic ductal adenocarcinoma missense_variant 1.863% (32/1718) 1 entry
ENSG00000167258 cecum adenocarcinoma missense_variant 3.704% (10/270) 1 entry
ENSG00000167258 lung adenocarcinoma missense_variant 1.362% (38/2789) 6 entries
ENSG00000167258 ovarian serous adenocarcinoma frameshift_variant 2.086% (19/911) 2 entries
ENSG00000167258 embryonal rhabdomyosarcoma missense_variant 2.326% (2/86) 1 entry
ENSG00000167258 skin melanoma stop_gained 2.238% (26/1162) 1 entry
ENSG00000167258 Endometrial Endometrioid Adenocarcinoma missense_variant 2.615% (17/650) 2 entries
ENSG00000167258 breast carcinoma sequence_alteration 1.584% (25/1578) 1 entry
ENSG00000167258 ovarian neoplasm missense_variant 3.448% (2/58) 1 entry
ENSG00000167258 basal cell carcinoma missense_variant 10.29% (7/68) 2 entries
ENSG00000167258 rectal adenocarcinoma missense_variant 1.648% (9/546) 2 entries
ENSG00000167258 prostate carcinoma sequence_alteration 3.512% (17/484) 1 entry
ENSG00000167258 ovarian serous adenocarcinoma conservative_inframe_deletion 2.086% (19/911) 2 entries
ENSG00000167258 melanoma missense_variant 5.517% (8/145) 3 entries
ENSG00000167258 lobular breast carcinoma missense_variant 1.527% (4/262) 1 entry
ENSG00000167258 breast carcinoma missense_variant 1.584% (25/1578) 3 entries
ENSG00000167258 urothelial carcinoma missense_variant 8.14% (7/86) 1 entry
ENSG00000167258 gastric adenocarcinoma missense_variant 2.019% (19/941) 2 entries
ENSG00000167258 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 1.515% (4/264) 2 entries
ENSG00000167258 Endometrial Endometrioid Adenocarcinoma frameshift_variant 2.615% (17/650) 1 entry
ENSG00000167258 prostate carcinoma missense_variant 3.512% (17/484) 1 entry
ENSG00000167258 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000167258 breast ductal adenocarcinoma stop_gained 2.959% (49/1656) 1 entry
ENSG00000167258 esophageal squamous cell carcinoma missense_variant 1.895% (13/686) 4 entries
ENSG00000167258 Ovarian Carcinosarcoma frameshift_variant 14.29% (2/14) 1 entry
ENSG00000167258 breast ductal adenocarcinoma sequence_alteration 2.959% (49/1656) 1 entry
ENSG00000167258 squamous cell lung carcinoma missense_variant 0.7984% (8/1002) 3 entries
ENSG00000167258 rectal adenocarcinoma frameshift_variant 1.648% (9/546) 1 entry
ENSG00000167258 breast carcinoma stop_gained 1.584% (25/1578) 1 entry
ENSG00000167258 basal cell carcinoma stop_gained 10.29% (7/68) 2 entries
ENSG00000167258 breast ductal adenocarcinoma missense_variant 2.959% (49/1656) 3 entries
ENSG00000167258 bile duct adenocarcinoma missense_variant 0.5115% (2/391) 1 entry
ENSG00000167258 Malignant Ovarian Mixed Epithelial Tumor missense_variant 20.0% (2/10) 1 entry
ENSG00000167258 hepatocellular carcinoma missense_variant 1.218% (12/985) 1 entry
ENSG00000167258 colon adenocarcinoma conservative_inframe_deletion 3.79% (49/1293) 1 entry
ENSG00000167258 brain glioblastoma missense_variant 0.9076% (11/1212) 1 entry
ENSG00000167258 clear cell renal carcinoma sequence_alteration 0.6766% (10/1478) 1 entry
ENSG00000167258 gastric adenocarcinoma stop_gained 2.019% (19/941) 1 entry
ENSG00000167258 female breast carcinoma missense_variant 1.496% (6/401) 2 entries
ENSG00000167258 colon adenocarcinoma sequence_alteration 3.79% (49/1293) 1 entry
ENSG00000167258 ovarian serous adenocarcinoma missense_variant 2.086% (19/911) 2 entries
ENSG00000167258 prostate carcinoma frameshift_variant 3.512% (17/484) 1 entry
ENSG00000167258 non-small cell lung carcinoma missense_variant 2.632% (3/114) 3 entries
ENSG00000167258 skin melanoma missense_variant 2.238% (26/1162) 4 entries
ENSG00000167258 Invasive Breast Carcinoma missense_variant 4.444% (2/45) 1 entry
ENSG00000167258 lung adenocarcinoma stop_gained 1.362% (38/2789) 3 entries
ENSG00000167258 small cell lung carcinoma missense_variant 1.57% (7/446) 3 entries
ENSG00000167258 melanoma frameshift_variant 5.517% (8/145) 2 entries
ENSG00000167258 bladder transitional cell carcinoma missense_variant 4.113% (19/462) 3 entries
ENSG00000167258 cecum adenocarcinoma frameshift_variant 3.704% (10/270) 2 entries
ENSG00000167258 esophageal adenocarcinoma missense_variant 3.467% (19/548) 1 entry
ENSG00000167258 bladder transitional cell carcinoma sequence_alteration 4.113% (19/462) 1 entry
ENSG00000167258 squamous cell lung carcinoma stop_gained 0.7984% (8/1002) 1 entry
ENSG00000167258 ovarian sarcoma missense_variant 100.0% (1/1) 1 entry
ENSG00000167258 diffuse gastric adenocarcinoma missense_variant 1.22% (1/82) 1 entry
ENSG00000167258 Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor missense_variant 3.03% (1/33) 1 entry
ENSG00000167258 Ampulla of Vater Carcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000167258 melanoma sequence_alteration 5.517% (8/145) 1 entry
ENSG00000167258 pharyngeal squamous cell carcinoma frameshift_variant 1.399% (2/143) 1 entry
ENSG00000167258 ovarian carcinoma frameshift_variant 9.091% (1/11) 1 entry
ENSG00000167258 small intestinal adenocarcinoma missense_variant 9.524% (2/21) 1 entry
ENSG00000167258 skin melanoma frameshift_variant 2.238% (26/1162) 1 entry
ENSG00000167258 basal cell carcinoma sequence_alteration 10.29% (7/68) 1 entry
ENSG00000167258 leiomyosarcoma missense_variant 0.9901% (1/101) 1 entry
ENSG00000167258 rectal adenocarcinoma stop_gained 1.648% (9/546) 1 entry
ENSG00000167258 small cell lung carcinoma stop_gained 1.57% (7/446) 1 entry
ENSG00000167258 urothelial carcinoma frameshift_variant 8.14% (7/86) 1 entry
ENSG00000167258 cecum adenocarcinoma stop_gained 3.704% (10/270) 1 entry
ENSG00000167258 meningioma (disease) missense_variant 1.37% (1/73) 1 entry
ENSG00000167258 Thymic Carcinoma missense_variant 9.091% (1/11) 1 entry
ENSG00000167258 undifferentiated pleomorphic sarcoma missense_variant 1.613% (1/62) 1 entry
ENSG00000167258 neoplasm stop_gained 3.448% (1/29) 1 entry
ENSG00000167258 testicular seminoma frameshift_variant 2.353% (2/85) 1 entry
ENSG00000167258 gastric intestinal type adenocarcinoma frameshift_variant 3.529% (3/85) 1 entry
ENSG00000167258 pancreatic ductal adenocarcinoma frameshift_variant 1.863% (32/1718) 1 entry
ENSG00000167258 breast ductal adenocarcinoma conservative_inframe_deletion 2.959% (49/1656) 1 entry
ENSG00000167258 female breast carcinoma stop_gained 1.496% (6/401) 1 entry
ENSG00000167258 breast ductal adenocarcinoma frameshift_variant 2.959% (49/1656) 1 entry
ENSG00000167258 Merkel cell skin cancer missense_variant 2.128% (2/94) 1 entry
ENSG00000167258 pharyngeal squamous cell carcinoma missense_variant 1.399% (2/143) 1 entry
ENSG00000167258 head and neck squamous cell carcinoma missense_variant 0.159% (1/629) 1 entry
ENSG00000167258 gastric adenocarcinoma frameshift_variant 2.019% (19/941) 1 entry
ENSG00000167258 Endometrial Clear Cell Adenocarcinoma missense_variant 3.704% (1/27) 1 entry
ENSG00000167258 mucosal melanoma missense_variant 1.429% (1/70) 1 entry
ENSG00000167258 ependymoma sequence_alteration 1.852% (1/54) 1 entry
ENSG00000167258 papillary thyroid carcinoma missense_variant 0.2028% (1/493) 1 entry
ENSG00000167258 brain glioblastoma frameshift_variant 0.9076% (11/1212) 1 entry
ENSG00000167258 nasopharyngeal squamous cell carcinoma missense_variant 0.3247% (1/308) 1 entry
ENSG00000167258 soft tissue sarcoma missense_variant 0.3401% (1/294) 1 entry
ENSG00000167258 testicular seminoma sequence_alteration 2.353% (2/85) 1 entry
ENSG00000167258 Gallbladder Adenocarcinoma sequence_alteration 0.6061% (1/165) 1 entry
ENSG00000167258 oral squamous cell carcinoma missense_variant 0.3817% (1/262) 1 entry
ENSG00000167258 Mediastinal Malignant Germ Cell Tumor stop_gained 6.667% (1/15) 1 entry
ENSG00000167258 Lung Sarcomatoid Carcinoma missense_variant 7.143% (1/14) 1 entry
ENSG00000167258 mucosal melanoma frameshift_variant 1.429% (1/70) 1 entry
ENSG00000167258 adrenal cortex carcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000167258 hemangioblastoma sequence_alteration 2.857% (1/35) 1 entry
ENSG00000167258 esophageal squamous cell carcinoma sequence_alteration 1.895% (13/686) 1 entry
ENSG00000167258 large cell lung carcinoma missense_variant 4.0% (1/25) 1 entry
ENSG00000167258 Pleural Epithelioid Mesothelioma missense_variant 0.4878% (1/205) 1 entry
ENSG00000167258 small cell lung carcinoma frameshift_variant 1.57% (7/446) 1 entry
ENSG00000167258 gastric adenocarcinoma conservative_inframe_deletion 2.019% (19/941) 1 entry
ENSG00000167258 Merkel cell skin cancer stop_gained 2.128% (2/94) 1 entry
ENSG00000167258 salivary gland carcinoma frameshift_variant 3.03% (1/33) 1 entry
ENSG00000167258 lung adenocarcinoma frameshift_variant 1.362% (38/2789) 1 entry
ENSG00000167258 cecum adenocarcinoma amino_acid_insertion 3.704% (10/270) 1 entry
ENSG00000167258 endometrial carcinoma missense_variant 3.448% (1/29) 1 entry
ENSG00000167258 lymphoid neoplasm missense_variant 6.599% (13/197) 1 entry
ENSG00000167258 small intestinal adenocarcinoma frameshift_variant 9.524% (2/21) 1 entry
ENSG00000167258 Adrenal Gland Neuroblastoma missense_variant 1.667% (1/60) 1 entry
ENSG00000167258 neoplasm missense_variant 3.448% (1/29) 1 entry
ENSG00000167258 clear cell renal carcinoma frameshift_variant 0.6766% (10/1478) 1 entry
ENSG00000167258 pancreatic neuroendocrine tumor missense_variant 3.814% (9/236) 1 entry
ENSG00000167258 small cell lung carcinoma sequence_alteration 1.57% (7/446) 1 entry
ENSG00000167258 Pancreatic Acinar Cell Carcinoma missense_variant 2.941% (1/34) 1 entry
ENSG00000167258 hepatocellular carcinoma frameshift_variant 1.218% (12/985) 1 entry
ENSG00000167258 Uveal Melanoma missense_variant 0.7812% (1/128) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167258 MESO 0.0018 high
ENSG00000167258 SARC 0.043 high
ENSG00000167258 CHOL 0.036 high
ENSG00000167258 UVM 0.039 high
ENSG00000167258 PAAD 0.0085 high
ENSG00000167258 THCA 0.022 high
ENSG00000167258 ACC 0.007 high
ENSG00000167258 LGG 0.0016 high
ENSG00000167258 READ 0.00057 low
ENSG00000167258 KIRP 0.00014 high
ENSG00000167258 KICH 0.00093 high
ENSG00000167258 PCPG 0.041 low
ENSG00000167258 OV 0.0013 high
ENSG00000167258 KIRC 0.0051 low
ENSG00000167258 BLCA 0.04 high
ENSG00000167258 LAML 0.00027 low
ENSG00000167258 GBM 0.015 high
ENSG00000167258 SKCM 0.03 high
ENSG00000167258 LIHC 0.0027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167258 LUAD Amp 2.342704 0.156498 0.431782 0.436047
ENSG00000167258 CESC Amp 1.540004 0.161275 0.760537 0.169492
ENSG00000167258 ACC Del 2.670751 0.169615 0.585419 0.300000
ENSG00000167258 READ Amp 2.630177 0.216761 0.685100 0.260606
ENSG00000167258 COAD Amp 9.387927 0.201910 0.674314 0.246120
ENSG00000167258 UCS Amp 1.069216 0.556256 0.957871 0.392857
ENSG00000167258 SARC Del 1.307159 0.139439 0.443235 0.272374
ENSG00000167258 PAAD Amp 1.386381 0.104963 0.506451 0.163043
ENSG00000167258 ESCA Amp 16.560850 0.892085 1.159289 0.396739
ENSG00000167258 HNSC Amp 2.170222 0.151057 0.603125 0.168582
ENSG00000167258 PCPG Del 4.107941 0.118290 0.642095 0.222222
ENSG00000167258 BLCA Amp 2.604780 0.227759 0.543589 0.392157
ENSG00000167258 BRCA Amp 108.173350 0.855459 1.449162 0.296296
ENSG00000167258 BRCA Del 1.069839 0.066964 0.424365 0.262963
ENSG00000167258 STAD Amp 41.386111 0.735686 1.146410 0.301587
ENSG00000167258 UCEC Amp 20.263998 0.354887 1.362638 0.120594
ENSG00000167258 UCEC Del 1.693062 0.060259 0.563436 0.183673