Ensembl ID ENSG00000167085 Gene ID 5245 Accession 8912
Gene Symbol PHB1 Alias PHB;HEL-215;HEL-S-54e Full Name prohibitin 1
Position 17 : 49404049 - 49414905 Length 10857 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ENSG00000167085 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167085 PHB -0.6 2.26e-26 KIRC
ENSG00000167085 PHB 0.65 5.93e-16 BRCA
ENSG00000167085 PHB 0.66 1.14e-15 LUSC
ENSG00000167085 PHB 0.54 2.77e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167085 PHB tumor 10207067
ENSG00000167085 PHB tumor 10376528
ENSG00000167085 PHB tumour 11472367
ENSG00000167085 PHB tumour 11852914
ENSG00000167085 PHB tumor 12065415
ENSG00000167085 PHB tumor 12085232
ENSG00000167085 PHB breast cancer 12354477
ENSG00000167085 PHB ovarian cancer 12821355
ENSG00000167085 PHB stomach cancer 12923326
ENSG00000167085 PHB breast cancer 14500355
ENSG00000167085 PHB breast cancer 14500729
ENSG00000167085 PHB breast cancers 14609433
ENSG00000167085 PHB breast cancer 14652295
ENSG00000167085 PHB prostate cancer 14968116
ENSG00000167085 PHB breast cancer 15141164
ENSG00000167085 PHB tumor 15259061
ENSG00000167085 PHB malignant tumor 15346741
ENSG00000167085 PHB tumor 15378696
ENSG00000167085 PHB breast cancer 1540973
ENSG00000167085 PHB tumor 15576509
ENSG00000167085 PHB breast cancer 15614618
ENSG00000167085 PHB tumor 15717328
ENSG00000167085 PHB malignant tumors 15759318
ENSG00000167085 PHB tumor 15823758
ENSG00000167085 PHB cancer 15986332
ENSG00000167085 PHB tumour 16243714
ENSG00000167085 PHB tumor 16319068
ENSG00000167085 PHB tumor 16426920
ENSG00000167085 PHB tumour 16518872
ENSG00000167085 PHB prostate cancer 16733518
ENSG00000167085 PHB tumor 1684951
ENSG00000167085 PHB breast cancer 16849588
ENSG00000167085 PHB cancer 16861898
ENSG00000167085 PHB prostate cancer 16951178
ENSG00000167085 PHB prostate cancer 16964284
ENSG00000167085 PHB breast cancer 17004108
ENSG00000167085 PHB tumor 17043753
ENSG00000167085 PHB breast cancer 17207617
ENSG00000167085 PHB bladder cancer 17465217
ENSG00000167085 PHB tumour 17525078
ENSG00000167085 PHB ovarian cancer 17544200
ENSG00000167085 PHB cancer 17704829
ENSG00000167085 PHB tumor 17873902
ENSG00000167085 PHB breast cancer 17932104
ENSG00000167085 PHB ovarian cancer 18183577
ENSG00000167085 PHB cancer 18384941
ENSG00000167085 PHB ovarian cancer 18397521
ENSG00000167085 PHB tumor 18424265
ENSG00000167085 PHB tumor 18464584
ENSG00000167085 PHB tumor 18487222
ENSG00000167085 PHB breast cancer 18494604
ENSG00000167085 PHB gastric cancer 18709484
ENSG00000167085 PHB tumor 18763282
ENSG00000167085 PHB gastric cancer 18789835
ENSG00000167085 PHB cervical cancer 19016026
ENSG00000167085 PHB tumours 19071013
ENSG00000167085 PHB tumor 19207009
ENSG00000167085 PHB lung cancer 19294702
ENSG00000167085 PHB tumours 19635783
ENSG00000167085 PHB prostate cancer 19725029
ENSG00000167085 PHB tumor 19725052
ENSG00000167085 PHB cancer 19733482
ENSG00000167085 PHB tumor 20069396
ENSG00000167085 PHB gastric cancer 20440860
ENSG00000167085 PHB breast cancer 20525321
ENSG00000167085 PHB tumor 20687958
ENSG00000167085 PHB tumors 20700505
ENSG00000167085 PHB tumor 20731553
ENSG00000167085 PHB cancer 20856874
ENSG00000167085 PHB tumors 20935162
ENSG00000167085 PHB cancer 20946606
ENSG00000167085 PHB ovarian cancer 20957754
ENSG00000167085 PHB tumor 21061155
ENSG00000167085 PHB tumor 21136964
ENSG00000167085 PHB thyroid tumor 21152868
ENSG00000167085 PHB breast cancer 21246238
ENSG00000167085 PHB cancer 21251707
ENSG00000167085 PHB tumors 21275458
ENSG00000167085 PHB cancer 21276934
ENSG00000167085 PHB cancer 21305254
ENSG00000167085 PHB liver cancer 21318481
ENSG00000167085 PHB tumours 21329656
ENSG00000167085 PHB tumor 21489794
ENSG00000167085 PHB breast cancers 21566741
ENSG00000167085 PHB breast-cancer 21573431
ENSG00000167085 PHB tumor 21760917
ENSG00000167085 PHB prostate cancer 21896168
ENSG00000167085 PHB lung cancer 21903368
ENSG00000167085 PHB tumor 21961024
ENSG00000167085 PHB cancer 22049339
ENSG00000167085 PHB cancer 22118658
ENSG00000167085 PHB tumours 22125622
ENSG00000167085 PHB tumours 22179832
ENSG00000167085 PHB malignant brain tumor 22192797
ENSG00000167085 PHB ovarian cancer 22201905
ENSG00000167085 PHB cancer 22212092
ENSG00000167085 PHB tumor 22304787
ENSG00000167085 PHB cancer 22366088
ENSG00000167085 PHB cervical cancer 22388104
ENSG00000167085 PHB cancer 22410782
ENSG00000167085 PHB tumor 22481869
ENSG00000167085 PHB prostate cancer 22505583
ENSG00000167085 PHB tumor 22539317
ENSG00000167085 PHB ovarian cancer 22669161
ENSG00000167085 PHB tumour 22728421
ENSG00000167085 PHB pancreatic cancer 22800753
ENSG00000167085 PHB cancer 22869582
ENSG00000167085 PHB cervical cancer 22888751
ENSG00000167085 PHB tumour 22900193
ENSG00000167085 PHB cancer 22994754
ENSG00000167085 PHB tumor 22999872
ENSG00000167085 PHB colorectal cancer 23078151
ENSG00000167085 PHB gastric cancer 23098474
ENSG00000167085 PHB female breast cancer 23244120
ENSG00000167085 PHB ovarian cancer 23281375
ENSG00000167085 PHB tumor 23327602
ENSG00000167085 PHB colorectal cancer 23455180
ENSG00000167085 PHB tumor 23587357
ENSG00000167085 PHB tumour 23632485
ENSG00000167085 PHB breast cancer 23662067
ENSG00000167085 PHB cancer 23672003
ENSG00000167085 PHB breast cancer 23715748
ENSG00000167085 PHB tumor 23729363
ENSG00000167085 PHB tumor 23870455
ENSG00000167085 PHB cancer 23880933
ENSG00000167085 PHB tumor 24023253
ENSG00000167085 PHB cancer 24049173
ENSG00000167085 PHB prostate cancer 24103426
ENSG00000167085 PHB non-small cell lung cancer 24133587
ENSG00000167085 PHB tumor 24166496
ENSG00000167085 PHB tumour 24185039
ENSG00000167085 PHB cancer 24187485
ENSG00000167085 PHB tumour 24204768
ENSG00000167085 PHB breast cancer 24247619
ENSG00000167085 PHB tumor 24249679
ENSG00000167085 PHB cancer 24347342
ENSG00000167085 PHB prostate cancer 24376711
ENSG00000167085 PHB tumor 24380853
ENSG00000167085 PHB tumor 24402549
ENSG00000167085 PHB pancreatic cancer 24568222
ENSG00000167085 PHB tumour 24595445
ENSG00000167085 PHB tumor 24650883
ENSG00000167085 PHB cancer 24709813
ENSG00000167085 PHB cancer 24732013
ENSG00000167085 PHB tumor 24879411
ENSG00000167085 PHB Tumor 24884867
ENSG00000167085 PHB tumors 24966933
ENSG00000167085 PHB tumor 25031298
ENSG00000167085 PHB Cancer 25137407
ENSG00000167085 PHB cancer 25200342
ENSG00000167085 PHB cancer 25265021
ENSG00000167085 PHB tumors 25312047
ENSG00000167085 PHB cancer 25424834
ENSG00000167085 PHB cancers 25575814
ENSG00000167085 PHB ovarian epithelial tumor 25628924
ENSG00000167085 PHB cancer 25643977
ENSG00000167085 PHB cancer 25719244
ENSG00000167085 PHB tumor 25777779
ENSG00000167085 PHB cancer 25904163
ENSG00000167085 PHB tumor 25915942
ENSG00000167085 PHB cancer 26064897
ENSG00000167085 PHB cancer 26091791
ENSG00000167085 PHB tumour 26184160
ENSG00000167085 PHB Tumor 26231887
ENSG00000167085 PHB cancer 26234551
ENSG00000167085 PHB cancers 26327844
ENSG00000167085 PHB tumor 26401855
ENSG00000167085 PHB cancer 26450374
ENSG00000167085 PHB cancer 26497683
ENSG00000167085 PHB cancer 26536361
ENSG00000167085 PHB tumor 26623724
ENSG00000167085 PHB tumor 26751773
ENSG00000167085 PHB gallbladder cancer 27084680
ENSG00000167085 PHB cancer 27087191
ENSG00000167085 PHB breast cancer 27141874
ENSG00000167085 PHB tumor 27321184
ENSG00000167085 PHB tumor 27409164
ENSG00000167085 PHB tumor 27557820
ENSG00000167085 PHB Tumors 27594657
ENSG00000167085 PHB tumor 27602127
ENSG00000167085 PHB cancer 27845899
ENSG00000167085 PHB liver cancer 27981602
ENSG00000167085 PHB tumors 28123587
ENSG00000167085 PHB cancers 28240870
ENSG00000167085 PHB breast cancer 28272969
ENSG00000167085 PHB gastric cancer 28294412
ENSG00000167085 PHB ovarian cancer 28360526
ENSG00000167085 PHB cancer 28399645
ENSG00000167085 PHB cancers 28404970
ENSG00000167085 PHB tumours 28414306
ENSG00000167085 PHB ovarian tumors 28427435
ENSG00000167085 PHB tumor 28440457
ENSG00000167085 PHB prostate cancer 28504694
ENSG00000167085 PHB Cancer 28714224
ENSG00000167085 PHB cancer 28721818
ENSG00000167085 PHB tumours 28846116
ENSG00000167085 PHB prostate cancer 28878155
ENSG00000167085 PHB tumor 29029444
ENSG00000167085 PHB colorectal cancer 29100316
ENSG00000167085 PHB tumor 29126391
ENSG00000167085 PHB breast cancer 29138518
ENSG00000167085 PHB liver cancer 29208281
ENSG00000167085 PHB cancer 29222040
ENSG00000167085 PHB cancer 29324904
ENSG00000167085 PHB cancer 29383012
ENSG00000167085 PHB tumor 29415747
ENSG00000167085 PHB breast cancer 29433565
ENSG00000167085 PHB tumor 29620269
ENSG00000167085 PHB cancer 29643415
ENSG00000167085 PHB tumor 29662647
ENSG00000167085 PHB cancer 29784973
ENSG00000167085 PHB breast cancer 29927945
ENSG00000167085 PHB prostate cancer 29956684
ENSG00000167085 PHB cancers 29960207
ENSG00000167085 PHB gastric cancer 29963172
ENSG00000167085 PHB cancers 30023262
ENSG00000167085 PHB cancer 30150937
ENSG00000167085 PHB breast cancer 30180900
ENSG00000167085 PHB pancreatic cancer 30185797
ENSG00000167085 PHB Metastatic Prostate Cancer 30396985
ENSG00000167085 PHB breast cancer 30423940
ENSG00000167085 PHB cancer 30501123
ENSG00000167085 PHB liver cancers 30523154
ENSG00000167085 PHB cancer 30538468
ENSG00000167085 PHB gastric cancer 30551681
ENSG00000167085 PHB tumor 30555578
ENSG00000167085 PHB Liver Cancer 30556043
ENSG00000167085 PHB tumor 30560903
ENSG00000167085 PHB cancer 30567335
ENSG00000167085 PHB cancer 30597288
ENSG00000167085 PHB cancer 30597867
ENSG00000167085 PHB cancer 30669391
ENSG00000167085 PHB cervical cancer 30674441
ENSG00000167085 PHB tumor 30697295
ENSG00000167085 PHB cancer 30717609
ENSG00000167085 PHB ovarian cancer 30736320
ENSG00000167085 PHB cancers 30886235
ENSG00000167085 PHB tumor 30926401
ENSG00000167085 PHB cancer 30950202
ENSG00000167085 PHB tumors 30998507
ENSG00000167085 PHB tumor 31118075
ENSG00000167085 PHB cancer 31177901
ENSG00000167085 PHB Endometrial Cancer 31205517
ENSG00000167085 PHB tumor 31258791
ENSG00000167085 PHB Wilms' tumor 31391345
ENSG00000167085 PHB tumor 31413875
ENSG00000167085 PHB liver cancer 31507318
ENSG00000167085 PHB breast cancer 31614178
ENSG00000167085 PHB lung cancer 31620250
ENSG00000167085 PHB tumor 31684984
ENSG00000167085 PHB breast cancer 31761183
ENSG00000167085 PHB liver tumor 6128081
ENSG00000167085 PHB tumours 7734302
ENSG00000167085 PHB tumor 7796893
ENSG00000167085 PHB breast cancer 7819270
ENSG00000167085 PHB tumor 7843414
ENSG00000167085 PHB breast cancer 8062216
ENSG00000167085 PHB tumor 8198603
ENSG00000167085 PHB tumors 8244394
ENSG00000167085 PHB ovarian tumors 8349162
ENSG00000167085 PHB tumor 8591812
ENSG00000167085 PHB tumor 8612677
ENSG00000167085 PHB tumor 8706794
ENSG00000167085 PHB breast cancer 8809404
ENSG00000167085 PHB tumor 9101479
ENSG00000167085 PHB tumour 9259555
ENSG00000167085 PHB Tumors 9473733
ENSG00000167085 PHB Breast Cancer PMC2838404
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167085 PHB SARC 0.0034 high
ENSG00000167085 PHB CHOL 0.027 high
ENSG00000167085 PHB UVM 0.013 high
ENSG00000167085 PHB UCEC 0.0045 high
ENSG00000167085 PHB THCA 0.0017 low
ENSG00000167085 PHB LGG 0.00072 high
ENSG00000167085 PHB HNSC 2e-04 high
ENSG00000167085 PHB KICH 0.013 high
ENSG00000167085 PHB LUAD 0.0052 high
ENSG00000167085 PHB BRCA 0.00052 low
ENSG00000167085 PHB ESCA 0.018 high
ENSG00000167085 PHB OV 0.026 low
ENSG00000167085 PHB DLBC 0.02 low
ENSG00000167085 PHB KIRC 0.012 low
ENSG00000167085 PHB BLCA 0.0018 high
ENSG00000167085 PHB LAML 0.00061 high
ENSG00000167085 PHB SKCM 0.016 high
ENSG00000167085 PHB CESC 0.031 low
ENSG00000167085 PHB LIHC 7e-04 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167085 PHB SKCM Amp 1.277389 0.139623 0.523715 0.269755
ENSG00000167085 PHB BRCA Amp 45.262617 0.519874 0.967598 0.319444