Ensembl ID ENSG00000167004 Gene ID 2923 Accession 4606
Gene Symbol PDIA3 Alias P58;ER60;ERp57;ERp60;ERp61;GRP57;GRP58;PI-PLC;HsT17083;HEL-S-269;HEL-S-93n Full Name protein disulfide isomerase family A member 3
Position 15 : 43746394 - 43773279 Length 26886 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

ENSG00000167004 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167004 PDIA3 0.52 2.80e-18 KIRC
ENSG00000167004 PDIA3 0.56 2.79e-13 HNSC
ENSG00000167004 PDIA3 0.85 4.36e-12 BLCA
ENSG00000167004 PDIA3 0.87 5.35e-50 BRCA
ENSG00000167004 PDIA3 0.68 8.94e-17 KICH
ENSG00000167004 PDIA3 0.68 8.27e-18 LUSC
ENSG00000167004 PDIA3 0.57 5.16e-12 PRAD
ENSG00000167004 PDIA3 1.05 1.63e-19 UCEC
ENSG00000167004 PDIA3 0.92 3.03e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167004 PDIA3 stomach cancer 12923326
ENSG00000167004 PDIA3 tumor 14522930
ENSG00000167004 PDIA3 ovarian cancer 16036111
ENSG00000167004 PDIA3 gastric cancer 17188166
ENSG00000167004 PDIA3 cancer 17353921
ENSG00000167004 PDIA3 cancer 17456022
ENSG00000167004 PDIA3 tumor 18464797
ENSG00000167004 PDIA3 tumor 18684944
ENSG00000167004 PDIA3 prostate cancer 18751977
ENSG00000167004 PDIA3 tumour 19165151
ENSG00000167004 PDIA3 tumor 19243813
ENSG00000167004 PDIA3 breast cancer 19703194
ENSG00000167004 PDIA3 epithelial ovarian cancer 19714814
ENSG00000167004 PDIA3 tumor 19820934
ENSG00000167004 PDIA3 prostate cancer 20035634
ENSG00000167004 PDIA3 prostate cancer 20398754
ENSG00000167004 PDIA3 cancer 20544786
ENSG00000167004 PDIA3 ovarian cancer 20596667
ENSG00000167004 PDIA3 epithelial ovarian cancer 20596672
ENSG00000167004 PDIA3 cancers 21598303
ENSG00000167004 PDIA3 lung cancer 22126541
ENSG00000167004 PDIA3 cancer 22193987
ENSG00000167004 PDIA3 prostate cancer 22363243
ENSG00000167004 PDIA3 cancer 22470562
ENSG00000167004 PDIA3 tumor 22527124
ENSG00000167004 PDIA3 tumours 22578690
ENSG00000167004 PDIA3 tumors 23024775
ENSG00000167004 PDIA3 cancer 23118872
ENSG00000167004 PDIA3 colon cancer 23255428
ENSG00000167004 PDIA3 breast cancer 23625662
ENSG00000167004 PDIA3 breast cancer 23696074
ENSG00000167004 PDIA3 tumor 23762310
ENSG00000167004 PDIA3 cancer 23782473
ENSG00000167004 PDIA3 cancer 23957851
ENSG00000167004 PDIA3 cancer 24314218
ENSG00000167004 PDIA3 tumors 24490732
ENSG00000167004 PDIA3 gastric cancer 24594673
ENSG00000167004 PDIA3 GBM 24838487
ENSG00000167004 PDIA3 ovarian cancer 24961659
ENSG00000167004 PDIA3 cancer 25140900
ENSG00000167004 PDIA3 cervical cancer 25143744
ENSG00000167004 PDIA3 tumor 25556465
ENSG00000167004 PDIA3 laryngeal cancer 25605256
ENSG00000167004 PDIA3 gastric cancer 25688334
ENSG00000167004 PDIA3 ovarian cancer 26004124
ENSG00000167004 PDIA3 breast cancer 26125904
ENSG00000167004 PDIA3 tumor 26513173
ENSG00000167004 PDIA3 prostate cancer 26607390
ENSG00000167004 PDIA3 cancer 26621448
ENSG00000167004 PDIA3 cervical cancer 26745629
ENSG00000167004 PDIA3 prostate tumor 26771192
ENSG00000167004 PDIA3 colon cancer 26772958
ENSG00000167004 PDIA3 bladder cancer 27034531
ENSG00000167004 PDIA3 breast cancer 27041866
ENSG00000167004 PDIA3 tumor 27363653
ENSG00000167004 PDIA3 epithelial ovarian cancer 27492604
ENSG00000167004 PDIA3 tumour 27566066
ENSG00000167004 PDIA3 cancer 28044092
ENSG00000167004 PDIA3 tumor 28097424
ENSG00000167004 PDIA3 cancer 28101228
ENSG00000167004 PDIA3 cancers 28250389
ENSG00000167004 PDIA3 lung cancer 28302866
ENSG00000167004 PDIA3 tumors 28373975
ENSG00000167004 PDIA3 cancer 28723413
ENSG00000167004 PDIA3 cancer 28796255
ENSG00000167004 PDIA3 endometrial cancer 28938593
ENSG00000167004 PDIA3 cancer 28967196
ENSG00000167004 PDIA3 tumor 29207176
ENSG00000167004 PDIA3 non-small cell lung cancer 29228584
ENSG00000167004 PDIA3 ovarian cancer 29262583
ENSG00000167004 PDIA3 cancers 29477346
ENSG00000167004 PDIA3 Cancer 29844689
ENSG00000167004 PDIA3 pancreatic cancer 29922073
ENSG00000167004 PDIA3 cancers 30050307
ENSG00000167004 PDIA3 tumor 30076294
ENSG00000167004 PDIA3 epithelial ovarian cancer 30221734
ENSG00000167004 PDIA3 tumor 30301907
ENSG00000167004 PDIA3 Testicular cancer 30320184
ENSG00000167004 PDIA3 ovarian cancer 30431082
ENSG00000167004 PDIA3 cancer 30658391
ENSG00000167004 PDIA3 bladder cancer 30708028
ENSG00000167004 PDIA3 gastric cancer 30720117
ENSG00000167004 PDIA3 tumor 31258820
ENSG00000167004 PDIA3 GBM 31548728
ENSG00000167004 PDIA3 GBM 31633244
ENSG00000167004 PDIA3 rectal cancer 31696471
ENSG00000167004 PDIA3 cancer 31749945
ENSG00000167004 PDIA3 cancer 31783195
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167004 PDIA3 MESO 0.011 low
ENSG00000167004 PDIA3 PAAD 0.014 high
ENSG00000167004 PDIA3 UCEC 0.00024 low
ENSG00000167004 PDIA3 ACC 0.033 high
ENSG00000167004 PDIA3 LUSC 0.015 low
ENSG00000167004 PDIA3 KIRP 0.00015 high
ENSG00000167004 PDIA3 KICH 0.0021 high
ENSG00000167004 PDIA3 LUAD 0.021 high
ENSG00000167004 PDIA3 DLBC 0.00041 low
ENSG00000167004 PDIA3 LAML 0.0011 low
ENSG00000167004 PDIA3 GBM 0.03 high
ENSG00000167004 PDIA3 SKCM 0.0015 low
ENSG00000167004 PDIA3 CESC 0.0016 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167004 PDIA3 LUSC Del 1.921354 0.082117 0.337089 0.337325
ENSG00000167004 PDIA3 LUAD Del 4.537638 0.089382 0.322707 0.521318
ENSG00000167004 PDIA3 CESC Del 2.322033 0.096154 0.460858 0.227119
ENSG00000167004 PDIA3 READ Del 0.664372 0.070864 0.471682 0.478788
ENSG00000167004 PDIA3 COAD Del 3.598318 0.070096 0.473044 0.374723
ENSG00000167004 PDIA3 UCS Del 4.029579 0.423393 0.542161 0.750000
ENSG00000167004 PDIA3 GBM Del 7.768790 0.111455 0.511834 0.247834
ENSG00000167004 PDIA3 SKCM Del 9.593119 0.165200 0.519931 0.250681
ENSG00000167004 PDIA3 DLBC Del 1.752853 0.182697 0.562048 0.229167
ENSG00000167004 PDIA3 BRCA Del 7.881565 0.106160 0.401033 0.359259
ENSG00000167004 PDIA3 STAD Del 1.062750 0.066039 0.321727 0.258503
ENSG00000167004 PDIA3 UCEC Del 3.849661 0.079742 0.519386 0.254174
ENSG00000167004 PDIA3 MESO Del 6.948679 0.319817 0.594000 0.287356
ENSG00000167004 PDIA3 OV Del 12.331703 0.321242 0.591233 0.595855