Ensembl ID ENSG00000167004 Gene ID 2923 Accession 4606
Gene Symbol PDIA3 Alias P58;ER60;ERp57;ERp60;ERp61;GRP57;GRP58;PI-PLC;HsT17083;HEL-S-269;HEL-S-93n Full Name protein disulfide isomerase family A member 3
Position 15 : 43746394 - 43773279 Length 26886 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

ENSG00000167004 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167004 0.52 2.80e-18 KIRC
ENSG00000167004 0.56 2.79e-13 HNSC
ENSG00000167004 0.85 4.36e-12 BLCA
ENSG00000167004 0.87 5.35e-50 BRCA
ENSG00000167004 0.68 8.94e-17 KICH
ENSG00000167004 0.68 8.27e-18 LUSC
ENSG00000167004 0.57 5.16e-12 PRAD
ENSG00000167004 1.05 1.63e-19 UCEC
ENSG00000167004 0.92 3.03e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167004 stomach cancer 12923326
ENSG00000167004 tumor 14522930
ENSG00000167004 ovarian cancer 16036111
ENSG00000167004 gastric cancer 17188166
ENSG00000167004 cancer 17353921
ENSG00000167004 cancer 17456022
ENSG00000167004 tumor 18464797
ENSG00000167004 tumor 18684944
ENSG00000167004 prostate cancer 18751977
ENSG00000167004 tumour 19165151
ENSG00000167004 tumor 19243813
ENSG00000167004 breast cancer 19703194
ENSG00000167004 epithelial ovarian cancer 19714814
ENSG00000167004 tumor 19820934
ENSG00000167004 prostate cancer 20035634
ENSG00000167004 prostate cancer 20398754
ENSG00000167004 cancer 20544786
ENSG00000167004 ovarian cancer 20596667
ENSG00000167004 epithelial ovarian cancer 20596672
ENSG00000167004 cancers 21598303
ENSG00000167004 lung cancer 22126541
ENSG00000167004 cancer 22193987
ENSG00000167004 prostate cancer 22363243
ENSG00000167004 cancer 22470562
ENSG00000167004 tumor 22527124
ENSG00000167004 tumours 22578690
ENSG00000167004 tumors 23024775
ENSG00000167004 cancer 23118872
ENSG00000167004 colon cancer 23255428
ENSG00000167004 breast cancer 23625662
ENSG00000167004 breast cancer 23696074
ENSG00000167004 tumor 23762310
ENSG00000167004 cancer 23782473
ENSG00000167004 cancer 23957851
ENSG00000167004 cancer 24314218
ENSG00000167004 tumors 24490732
ENSG00000167004 gastric cancer 24594673
ENSG00000167004 GBM 24838487
ENSG00000167004 ovarian cancer 24961659
ENSG00000167004 cancer 25140900
ENSG00000167004 cervical cancer 25143744
ENSG00000167004 tumor 25556465
ENSG00000167004 laryngeal cancer 25605256
ENSG00000167004 gastric cancer 25688334
ENSG00000167004 ovarian cancer 26004124
ENSG00000167004 breast cancer 26125904
ENSG00000167004 tumor 26513173
ENSG00000167004 prostate cancer 26607390
ENSG00000167004 cancer 26621448
ENSG00000167004 cervical cancer 26745629
ENSG00000167004 prostate tumor 26771192
ENSG00000167004 colon cancer 26772958
ENSG00000167004 bladder cancer 27034531
ENSG00000167004 breast cancer 27041866
ENSG00000167004 tumor 27363653
ENSG00000167004 epithelial ovarian cancer 27492604
ENSG00000167004 tumour 27566066
ENSG00000167004 cancer 28044092
ENSG00000167004 tumor 28097424
ENSG00000167004 cancer 28101228
ENSG00000167004 cancers 28250389
ENSG00000167004 lung cancer 28302866
ENSG00000167004 tumors 28373975
ENSG00000167004 cancer 28723413
ENSG00000167004 cancer 28796255
ENSG00000167004 endometrial cancer 28938593
ENSG00000167004 cancer 28967196
ENSG00000167004 tumor 29207176
ENSG00000167004 non-small cell lung cancer 29228584
ENSG00000167004 ovarian cancer 29262583
ENSG00000167004 cancers 29477346
ENSG00000167004 Cancer 29844689
ENSG00000167004 pancreatic cancer 29922073
ENSG00000167004 cancers 30050307
ENSG00000167004 tumor 30076294
ENSG00000167004 epithelial ovarian cancer 30221734
ENSG00000167004 tumor 30301907
ENSG00000167004 Testicular cancer 30320184
ENSG00000167004 ovarian cancer 30431082
ENSG00000167004 cancer 30658391
ENSG00000167004 bladder cancer 30708028
ENSG00000167004 gastric cancer 30720117
ENSG00000167004 tumor 31258820
ENSG00000167004 GBM 31548728
ENSG00000167004 GBM 31633244
ENSG00000167004 rectal cancer 31696471
ENSG00000167004 cancer 31749945
ENSG00000167004 cancer 31783195
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167004 MESO 0.011 low
ENSG00000167004 PAAD 0.014 high
ENSG00000167004 UCEC 0.00024 low
ENSG00000167004 ACC 0.033 high
ENSG00000167004 LUSC 0.015 low
ENSG00000167004 KIRP 0.00015 high
ENSG00000167004 KICH 0.0021 high
ENSG00000167004 LUAD 0.021 high
ENSG00000167004 DLBC 0.00041 low
ENSG00000167004 LAML 0.0011 low
ENSG00000167004 GBM 0.03 high
ENSG00000167004 SKCM 0.0015 low
ENSG00000167004 CESC 0.0016 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167004 LUSC Del 1.921354 0.082117 0.337089 0.337325
ENSG00000167004 LUAD Del 4.537638 0.089382 0.322707 0.521318
ENSG00000167004 CESC Del 2.322033 0.096154 0.460858 0.227119
ENSG00000167004 READ Del 0.664372 0.070864 0.471682 0.478788
ENSG00000167004 COAD Del 3.598318 0.070096 0.473044 0.374723
ENSG00000167004 UCS Del 4.029579 0.423393 0.542161 0.750000
ENSG00000167004 GBM Del 7.768790 0.111455 0.511834 0.247834
ENSG00000167004 SKCM Del 9.593119 0.165200 0.519931 0.250681
ENSG00000167004 DLBC Del 1.752853 0.182697 0.562048 0.229167
ENSG00000167004 BRCA Del 7.881565 0.106160 0.401033 0.359259
ENSG00000167004 STAD Del 1.062750 0.066039 0.321727 0.258503
ENSG00000167004 UCEC Del 3.849661 0.079742 0.519386 0.254174
ENSG00000167004 MESO Del 6.948679 0.319817 0.594000 0.287356
ENSG00000167004 OV Del 12.331703 0.321242 0.591233 0.595855