Ensembl ID ENSG00000166508 Gene ID 4176 Accession 6950
Gene Symbol MCM7 Alias MCM2;CDC47;P85MCM;P1CDC47;PNAS146;PPP1R104;P1.1-MCM3 Full Name minichromosome maintenance complex component 7
Position 7 : 100092728 - 100101940 Length 9213 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

ENSG00000166508 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000166508 MCM7 0.96 3.99e-53 KIRC
ENSG00000166508 MCM7 1.21 7.79e-26 HNSC
ENSG00000166508 MCM7 0.77 5.44e-23 BRCA
ENSG00000166508 MCM7 1.27 3.12e-31 COAD
ENSG00000166508 MCM7 2.05 3.68e-99 LUSC
ENSG00000166508 MCM7 1.12 3.80e-26 KIRP
ENSG00000166508 MCM7 1.47 3.64e-29 LIHC
ENSG00000166508 MCM7 1.24 1.55e-15 STAD
ENSG00000166508 MCM7 1.27 8.04e-22 UCEC
ENSG00000166508 MCM7 1.87 4.96e-13 ESCA
ENSG00000166508 MCM7 1.36 3.17e-13 CHOL
ENSG00000166508 MCM7 1.27 2.87e-27 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000166508 MCM7 tumors 11861392
ENSG00000166508 MCM7 tumor 14550576
ENSG00000166508 MCM7 cervical cancer 14678972
ENSG00000166508 MCM7 tumors 15668898
ENSG00000166508 MCM7 tumour 15720416
ENSG00000166508 MCM7 prostate cancer 16247466
ENSG00000166508 MCM7 tumor 16518415
ENSG00000166508 MCM7 differentiated thyroid cancers 16547620
ENSG00000166508 MCM7 tumor 16930994
ENSG00000166508 MCM7 head and neck cancer 16959885
ENSG00000166508 MCM7 tumor 17094475
ENSG00000166508 MCM7 tumour 18349847
ENSG00000166508 MCM7 pancreatic cancer 18404646
ENSG00000166508 MCM7 prostate cancer 18521193
ENSG00000166508 MCM7 tumor 18636144
ENSG00000166508 MCM7 tumors 18676839
ENSG00000166508 MCM7 metastatic prostate cancer 18988800
ENSG00000166508 MCM7 tumor 18996480
ENSG00000166508 MCM7 tumor 19144445
ENSG00000166508 MCM7 colorectal cancer 19360293
ENSG00000166508 MCM7 tumor 19389522
ENSG00000166508 MCM7 tumour 19453809
ENSG00000166508 MCM7 tumours 20049725
ENSG00000166508 MCM7 malignant tumors 20136698
ENSG00000166508 MCM7 cancer 20388916
ENSG00000166508 MCM7 tumor 20460506
ENSG00000166508 MCM7 prostate cancer 20539323
ENSG00000166508 MCM7 tumor 20661220
ENSG00000166508 MCM7 lung cancer 20735959
ENSG00000166508 MCM7 cancer 21063399
ENSG00000166508 MCM7 ovarian cancer 21076460
ENSG00000166508 MCM7 tumor 21267686
ENSG00000166508 MCM7 tumours 21478101
ENSG00000166508 MCM7 tumor 21556246
ENSG00000166508 MCM7 prostate cancer 21592298
ENSG00000166508 MCM7 tumor 21603321
ENSG00000166508 MCM7 cancer 21619671
ENSG00000166508 MCM7 pituitary tumors 21982272
ENSG00000166508 MCM7 lung cancer 22211244
ENSG00000166508 MCM7 tumours 22235877
ENSG00000166508 MCM7 tumour 22333708
ENSG00000166508 MCM7 cancer 22355461
ENSG00000166508 MCM7 tumors 22456526
ENSG00000166508 MCM7 tumor 22685420
ENSG00000166508 MCM7 tumors 22767360
ENSG00000166508 MCM7 cancer 22838965
ENSG00000166508 MCM7 tumor 23028803
ENSG00000166508 MCM7 bladder cancer 23201130
ENSG00000166508 MCM7 cancers 23336032
ENSG00000166508 MCM7 tumor 23463632
ENSG00000166508 MCM7 cervical cancers 23523766
ENSG00000166508 MCM7 cancer 23641142
ENSG00000166508 MCM7 tumor 23727861
ENSG00000166508 MCM7 cancers 23764002
ENSG00000166508 MCM7 tumors 23874974
ENSG00000166508 MCM7 thyroid tumor 23895847
ENSG00000166508 MCM7 tumors 23982162
ENSG00000166508 MCM7 tumors 24086435
ENSG00000166508 MCM7 GBM 24166506
ENSG00000166508 MCM7 cancer 24466173
ENSG00000166508 MCM7 tumors 24525739
ENSG00000166508 MCM7 tumors 24621503
ENSG00000166508 MCM7 gastric cancer 24647462
ENSG00000166508 MCM7 tumor 24763826
ENSG00000166508 MCM7 tumour 24805087
ENSG00000166508 MCM7 Tumor 25045014
ENSG00000166508 MCM7 tumor 25046975
ENSG00000166508 MCM7 colorectal cancer 25075101
ENSG00000166508 MCM7 tumors 25232279
ENSG00000166508 MCM7 tumour 25372501
ENSG00000166508 MCM7 cancer 25393367
ENSG00000166508 MCM7 pancreatic cancer 25502777
ENSG00000166508 MCM7 peritoneal cancer 25777091
ENSG00000166508 MCM7 gastric cancer 25916094
ENSG00000166508 MCM7 tumor 25961212
ENSG00000166508 MCM7 prostate cancer 26059417
ENSG00000166508 MCM7 esophageal cancers 26156831
ENSG00000166508 MCM7 HNSCC 26239836
ENSG00000166508 MCM7 tumor 26253138
ENSG00000166508 MCM7 breast cancer 26282201
ENSG00000166508 MCM7 liver cancer 26309496
ENSG00000166508 MCM7 cancers 26408331
ENSG00000166508 MCM7 tumors 26620390
ENSG00000166508 MCM7 breast cancer 26722252
ENSG00000166508 MCM7 bladder cancer 26966728
ENSG00000166508 MCM7 cancers 27190216
ENSG00000166508 MCM7 tumor 27298561
ENSG00000166508 MCM7 lung tumors 27797825
ENSG00000166508 MCM7 cancer 27837251
ENSG00000166508 MCM7 tumor 27868157
ENSG00000166508 MCM7 cervical cancer 27911853
ENSG00000166508 MCM7 tumor 28032719
ENSG00000166508 MCM7 cancers 28058629
ENSG00000166508 MCM7 gastric cancer 28059478
ENSG00000166508 MCM7 gastric cancer 28123545
ENSG00000166508 MCM7 breast cancer 28150753
ENSG00000166508 MCM7 tumors 28182015
ENSG00000166508 MCM7 tumors 28300827
ENSG00000166508 MCM7 prostate cancer 28424404
ENSG00000166508 MCM7 tumor 28432562
ENSG00000166508 MCM7 lung cancer 28465488
ENSG00000166508 MCM7 tumor 28498460
ENSG00000166508 MCM7 Gastric Cancer 28540486
ENSG00000166508 MCM7 breast cancer 28668890
ENSG00000166508 MCM7 breast cancer 28932124
ENSG00000166508 MCM7 tumor 28983113
ENSG00000166508 MCM7 tumor 28983330
ENSG00000166508 MCM7 tumors 29179453
ENSG00000166508 MCM7 tumor 29180899
ENSG00000166508 MCM7 tumor 29285216
ENSG00000166508 MCM7 Breast cancer 29402894
ENSG00000166508 MCM7 skin cancer 29459852
ENSG00000166508 MCM7 tumor 29463213
ENSG00000166508 MCM7 breast cancer 29662198
ENSG00000166508 MCM7 cancers 29721062
ENSG00000166508 MCM7 prostate cancer 29765562
ENSG00000166508 MCM7 esophageal cancer 29922071
ENSG00000166508 MCM7 tumours 29989314
ENSG00000166508 MCM7 cancer 30026832
ENSG00000166508 MCM7 cancer 30042885
ENSG00000166508 MCM7 cancer 30062004
ENSG00000166508 MCM7 tumor 30233242
ENSG00000166508 MCM7 tumor 30365225
ENSG00000166508 MCM7 tumor 30447299
ENSG00000166508 MCM7 AML 30480765
ENSG00000166508 MCM7 tumor 30907426
ENSG00000166508 MCM7 DLBCL 31044434
ENSG00000166508 MCM7 tumor 31186405
ENSG00000166508 MCM7 tumor 31234753
ENSG00000166508 MCM7 tumor 31579068
ENSG00000166508 MCM7 cancer 31640696
ENSG00000166508 MCM7 tumor 31695969
ENSG00000166508 MCM7 acute myeloid leukemia (AML) 31936215
ENSG00000166508 MCM7 tumor 31966536
ENSG00000166508 MCM7 cancer 31983282
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000166508 MCM7 MESO 0.0039 high
ENSG00000166508 MCM7 SARC 0.029 high
ENSG00000166508 MCM7 CHOL 0.0022 low
ENSG00000166508 MCM7 UVM 0.014 low
ENSG00000166508 MCM7 UCEC 0.024 low
ENSG00000166508 MCM7 THCA 0.0027 low
ENSG00000166508 MCM7 LGG 0.0046 high
ENSG00000166508 MCM7 LUSC 0.00064 low
ENSG00000166508 MCM7 READ 0.0023 low
ENSG00000166508 MCM7 KIRP 0.0035 high
ENSG00000166508 MCM7 LUAD 0.0018 high
ENSG00000166508 MCM7 THYM 0.0017 low
ENSG00000166508 MCM7 OV 0.036 low
ENSG00000166508 MCM7 SKCM 0.036 high
ENSG00000166508 MCM7 CESC 0.00025 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000166508 MCM7 LUSC Amp 1.450029 0.219114 0.540308 0.508982
ENSG00000166508 MCM7 LUAD Amp 1.037177 0.126287 0.464571 0.430233
ENSG00000166508 MCM7 LGG Amp 1.480082 0.055522 0.657381 0.319688
ENSG00000166508 MCM7 PAAD Amp 1.250323 0.100179 0.449374 0.288043
ENSG00000166508 MCM7 ESCA Amp 6.296861 0.529165 0.734080 0.565217
ENSG00000166508 MCM7 HNSC Amp 6.589295 0.228436 0.592004 0.325670
ENSG00000166508 MCM7 STAD Amp 11.071324 0.345027 0.642331 0.453515
ENSG00000166508 MCM7 UCEC Amp 0.855325 0.106958 0.647093 0.174397