Ensembl ID ENSG00000166181 Gene ID 8539 Accession 594
Gene Symbol API5 Alias AAC11;AAC-11 Full Name apoptosis inhibitor 5
Position 11 : 43311963 - 43344529 Length 32567 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Non-canonical_RBPs
Summary This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

ENSG00000166181 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000166181 API5 -0.4 6.09e-21 KIRC
ENSG00000166181 API5 -0.4 8.45e-11 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000166181 API5 cervical cancer 10780674
ENSG00000166181 API5 non-small cell lung cancer 11557113
ENSG00000166181 API5 tumor 16264268
ENSG00000166181 API5 breast cancer 17022634
ENSG00000166181 API5 tumor 17112319
ENSG00000166181 API5 cancer 19387494
ENSG00000166181 API5 cancer 20001210
ENSG00000166181 API5 tumor 20671611
ENSG00000166181 API5 breast cancer 21289334
ENSG00000166181 API5 cancer 22334682
ENSG00000166181 API5 tumor 22741017
ENSG00000166181 API5 tumor 23615981
ENSG00000166181 API5 tumor 24769442
ENSG00000166181 API5 prostate cancer 25004126
ENSG00000166181 API5 cervical cancer 25070070
ENSG00000166181 API5 tumour 25204737
ENSG00000166181 API5 cervical cancer 25248562
ENSG00000166181 API5 liver cancer 25433291
ENSG00000166181 API5 Tumor 25477374
ENSG00000166181 API5 tumor 25526772
ENSG00000166181 API5 gastric cancer 26840027
ENSG00000166181 API5 Cancer 27406828
ENSG00000166181 API5 cancer 28092370
ENSG00000166181 API5 breast cancer 28360536
ENSG00000166181 API5 cancer 28881748
ENSG00000166181 API5 cervical cancer 28883546
ENSG00000166181 API5 cancer 30080874
ENSG00000166181 API5 cancer 30288341
ENSG00000166181 API5 breast cancer 30384804
ENSG00000166181 API5 tumor 31152681
ENSG00000166181 API5 tumors 31762939
ENSG00000166181 API5 tumours 8968744
ENSG00000166181 API5 tumor 9307294
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000166181 API5 MESO 0.019 high
ENSG00000166181 API5 STAD 0.023 low
ENSG00000166181 API5 PAAD 0.025 high
ENSG00000166181 API5 LGG 0.0099 low
ENSG00000166181 API5 HNSC 0.038 low
ENSG00000166181 API5 READ 0.0021 low
ENSG00000166181 API5 KICH 0.0024 high
ENSG00000166181 API5 LUAD 0.043 low
ENSG00000166181 API5 THYM 0.0086 low
ENSG00000166181 API5 BRCA 0.0011 high
ENSG00000166181 API5 UCS 0.036 low
ENSG00000166181 API5 OV 0.0015 low
ENSG00000166181 API5 BLCA 0.03 low
ENSG00000166181 API5 GBM 0.014 low
ENSG00000166181 API5 SKCM 0.0083 low
ENSG00000166181 API5 LIHC 0.0059 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000166181 API5 PRAD Del 0.962074 0.075477 0.539322 0.058943