Ensembl ID ENSG00000165916 Gene ID 5702 Accession 9549
Gene Symbol PSMC3 Alias RPT5;TBP1;DCIDP Full Name proteasome 26S subunit, ATPase 3
Position 11 : 47418769 - 47426473 Length 7705 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

ENSG00000165916 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000165916 PSMC3 0.48 8.04e-16 BRCA
ENSG00000165916 PSMC3 0.53 4.30e-13 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000165916 PSMC3 tumor 10339605
ENSG00000165916 PSMC3 tumor 12733146
ENSG00000165916 PSMC3 tumors 14556007
ENSG00000165916 PSMC3 tumor 14665636
ENSG00000165916 PSMC3 tumour 21874050
ENSG00000165916 PSMC3 tumor 21948970
ENSG00000165916 PSMC3 tumor 21991300
ENSG00000165916 PSMC3 breast cancer 25590583
ENSG00000165916 PSMC3 tumor 28435470
ENSG00000165916 PSMC3 breast cancer 30362169
ENSG00000165916 PSMC3 gastric cancer 30777076
ENSG00000165916 PSMC3 gastric cancer 31922886
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000165916 PSMC3 MESO 0.0026 high
ENSG00000165916 PSMC3 UVM 0.00018 high
ENSG00000165916 PSMC3 PAAD 0.035 high
ENSG00000165916 PSMC3 UCEC 0.004 low
ENSG00000165916 PSMC3 THCA 0.022 low
ENSG00000165916 PSMC3 LGG 0.024 low
ENSG00000165916 PSMC3 LUSC 0.01 low
ENSG00000165916 PSMC3 HNSC 0.03 low
ENSG00000165916 PSMC3 KIRP 0.00059 low
ENSG00000165916 PSMC3 KICH 0.00033 high
ENSG00000165916 PSMC3 LUAD 0.0084 high
ENSG00000165916 PSMC3 BRCA 0.0082 low
ENSG00000165916 PSMC3 COAD 0.013 high
ENSG00000165916 PSMC3 UCS 0.042 low
ENSG00000165916 PSMC3 ESCA 0.031 high
ENSG00000165916 PSMC3 OV 0.023 low
ENSG00000165916 PSMC3 KIRC 0.00017 high
ENSG00000165916 PSMC3 LAML 0.0019 high
ENSG00000165916 PSMC3 GBM 0.049 high
ENSG00000165916 PSMC3 SKCM 0.044 low
ENSG00000165916 PSMC3 CESC 0.008 low
ENSG00000165916 PSMC3 LIHC 0.01 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000165916 PSMC3 PRAD Del 0.971389 0.075697 0.555790 0.063008