Ensembl ID ENSG00000165916 Gene ID 5702 Accession 9549
Gene Symbol PSMC3 Alias RPT5;TBP1;DCIDP Full Name proteasome 26S subunit, ATPase 3
Position 11 : 47418769 - 47426473 Length 7705 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

ENSG00000165916 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000165916 0.48 8.04e-16 BRCA
ENSG00000165916 0.53 4.30e-13 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000165916 tumor 10339605
ENSG00000165916 tumor 12733146
ENSG00000165916 tumors 14556007
ENSG00000165916 tumor 14665636
ENSG00000165916 tumour 21874050
ENSG00000165916 tumor 21948970
ENSG00000165916 tumor 21991300
ENSG00000165916 breast cancer 25590583
ENSG00000165916 tumor 28435470
ENSG00000165916 breast cancer 30362169
ENSG00000165916 gastric cancer 30777076
ENSG00000165916 gastric cancer 31922886
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000165916 MESO 0.0026 high
ENSG00000165916 UVM 0.00018 high
ENSG00000165916 PAAD 0.035 high
ENSG00000165916 UCEC 0.004 low
ENSG00000165916 THCA 0.022 low
ENSG00000165916 LGG 0.024 low
ENSG00000165916 LUSC 0.01 low
ENSG00000165916 HNSC 0.03 low
ENSG00000165916 KIRP 0.00059 low
ENSG00000165916 KICH 0.00033 high
ENSG00000165916 LUAD 0.0084 high
ENSG00000165916 BRCA 0.0082 low
ENSG00000165916 COAD 0.013 high
ENSG00000165916 UCS 0.042 low
ENSG00000165916 ESCA 0.031 high
ENSG00000165916 OV 0.023 low
ENSG00000165916 KIRC 0.00017 high
ENSG00000165916 LAML 0.0019 high
ENSG00000165916 GBM 0.049 high
ENSG00000165916 SKCM 0.044 low
ENSG00000165916 CESC 0.008 low
ENSG00000165916 LIHC 0.01 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000165916 PRAD Del 0.971389 0.075697 0.555790 0.063008