Ensembl ID ENSG00000165672 Gene ID 10935 Accession 9354
Gene Symbol PRDX3 Alias AOP1;MER5;AOP-1;PPPCD;SP-22;HBC189;SCAR32;PRO1748;prx-III Full Name peroxiredoxin 3
Position 10 : 119167720 - 119178812 Length 11093 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

ENSG00000165672 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000165672 PRDX3 -0.8 4.65e-35 KIRC
ENSG00000165672 PRDX3 -0.5 5.56e-12 HNSC
ENSG00000165672 PRDX3 -1.0 5.05e-13 KICH
ENSG00000165672 PRDX3 -2.0 2.15e-13 PCPG
ENSG00000165672 PRDX3 -0.7 1.56e-15 LIHC
ENSG00000165672 PRDX3 -2.0 7.46e-20 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000165672 PRDX3 tumor 12530083
ENSG00000165672 PRDX3 cancer 12861054
ENSG00000165672 PRDX3 lung cancer 16635084
ENSG00000165672 PRDX3 breast cancer 17980029
ENSG00000165672 PRDX3 breast cancer 19566940
ENSG00000165672 PRDX3 breast cancer 20043069
ENSG00000165672 PRDX3 tumors 20307276
ENSG00000165672 PRDX3 breast cancer 20541551
ENSG00000165672 PRDX3 cervical cancer 20718351
ENSG00000165672 PRDX3 prostate cancer 21031435
ENSG00000165672 PRDX3 kidney cancer 21760917
ENSG00000165672 PRDX3 Lung Cancer 22016591
ENSG00000165672 PRDX3 cancer 22072940
ENSG00000165672 PRDX3 AML 22169282
ENSG00000165672 PRDX3 prostate cancer 22424448
ENSG00000165672 PRDX3 Cancer 22496757
ENSG00000165672 PRDX3 cancer 22628295
ENSG00000165672 PRDX3 prostate cancer 22710126
ENSG00000165672 PRDX3 endometrial cancer 22783432
ENSG00000165672 PRDX3 tumor 23077491
ENSG00000165672 PRDX3 cancer 23113308
ENSG00000165672 PRDX3 tumor 23157748
ENSG00000165672 PRDX3 tumor 23217164
ENSG00000165672 PRDX3 ovarian cancer 23503975
ENSG00000165672 PRDX3 epithelial ovarian cancer 23564483
ENSG00000165672 PRDX3 cervical cancer 23772374
ENSG00000165672 PRDX3 prostate cancer 23880827
ENSG00000165672 PRDX3 liver cancer 24105047
ENSG00000165672 PRDX3 cervical cancer 24648924
ENSG00000165672 PRDX3 tumor 24815434
ENSG00000165672 PRDX3 GBM 24838487
ENSG00000165672 PRDX3 tumor 25050814
ENSG00000165672 PRDX3 Tumor 25462069
ENSG00000165672 PRDX3 cancer 25875582
ENSG00000165672 PRDX3 tumor 26011724
ENSG00000165672 PRDX3 breast cancer 26061816
ENSG00000165672 PRDX3 colon tumor 26091938
ENSG00000165672 PRDX3 colon cancer 26350748
ENSG00000165672 PRDX3 cancers 26686468
ENSG00000165672 PRDX3 tumor 26722077
ENSG00000165672 PRDX3 tumor 26975474
ENSG00000165672 PRDX3 liver cancer 26983019
ENSG00000165672 PRDX3 cancer 27418953
ENSG00000165672 PRDX3 AML 27621603
ENSG00000165672 PRDX3 Cancer 27737148
ENSG00000165672 PRDX3 tumor 27966448
ENSG00000165672 PRDX3 cancer 28184180
ENSG00000165672 PRDX3 cancers 28240739
ENSG00000165672 PRDX3 cancer 28357082
ENSG00000165672 PRDX3 prostate cancer 29113303
ENSG00000165672 PRDX3 endometrial cancer 29190956
ENSG00000165672 PRDX3 endometrial cancer 29541251
ENSG00000165672 PRDX3 tumors 29545070
ENSG00000165672 PRDX3 ovarian cancer 30104402
ENSG00000165672 PRDX3 lung cancer 30568461
ENSG00000165672 PRDX3 ovarian cancer 30736320
ENSG00000165672 PRDX3 cancer 30950202
ENSG00000165672 PRDX3 ovarian cancer 31315664
ENSG00000165672 PRDX3 tumor 31402980
ENSG00000165672 PRDX3 Tumor 31636803
ENSG00000165672 PRDX3 cancer 31743887
ENSG00000165672 PRDX3 tumours 31771972
ENSG00000165672 PRDX3 tumour 31965757
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000165672 PRDX3 MESO 0.0026 low
ENSG00000165672 PRDX3 SARC 0.0049 low
ENSG00000165672 PRDX3 CHOL 0.031 high
ENSG00000165672 PRDX3 UVM 0.0065 high
ENSG00000165672 PRDX3 PAAD 0.011 high
ENSG00000165672 PRDX3 ACC 0.041 low
ENSG00000165672 PRDX3 HNSC 0.0012 high
ENSG00000165672 PRDX3 READ 0.0095 high
ENSG00000165672 PRDX3 KIRP 0.041 low
ENSG00000165672 PRDX3 KICH 0.025 high
ENSG00000165672 PRDX3 COAD 0.0075 high
ENSG00000165672 PRDX3 OV 0.012 low
ENSG00000165672 PRDX3 PRAD 0.012 high
ENSG00000165672 PRDX3 LAML 0.031 high
ENSG00000165672 PRDX3 LIHC 0.0033 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000165672 PRDX3 CHOL Del 1.158303 0.249611 0.508813 0.305556
ENSG00000165672 PRDX3 LGG Del 15.621420 0.132535 0.581449 0.284600
ENSG00000165672 PRDX3 COAD Del 1.551811 0.051852 0.339375 0.221729
ENSG00000165672 PRDX3 GBM Del 3.038700 0.076930 0.700290 0.894281
ENSG00000165672 PRDX3 LIHC Del 4.495114 0.116165 0.495328 0.286486
ENSG00000165672 PRDX3 BLCA Del 0.911715 0.080933 0.390257 0.392157
ENSG00000165672 PRDX3 BRCA Del 6.823936 0.101448 0.395414 0.297222
ENSG00000165672 PRDX3 STAD Del 0.659418 0.059902 0.338285 0.192744
ENSG00000165672 PRDX3 UCEC Del 1.433594 0.057447 0.510736 0.107607
ENSG00000165672 PRDX3 MESO Del 2.329675 0.189153 0.487022 0.344828
ENSG00000165672 PRDX3 OV Del 3.038489 0.219896 0.505173 0.343696