Ensembl ID ENSG00000165629 Gene ID 509 Accession 833
Gene Symbol ATP5F1C Alias ATP5C;ATP5C1;ATP5CL1 Full Name ATP synthase F1 subunit gamma
Position 10 : 7788177 - 7807815 Length 19639 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]

ENSG00000165629 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000165629 ATP5F1C -0.5 2.98e-16 KIRC
ENSG00000165629 ATP5F1C 0.50 9.74e-17 BRCA
ENSG00000165629 ATP5F1C 0.72 2.47e-17 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000165629 ATP5F1C tumor 22363440
ENSG00000165629 ATP5F1C colorectal cancer 23717594
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000165629 ATP5F1C MESO 0.0065 low
ENSG00000165629 ATP5F1C UVM 0.046 high
ENSG00000165629 ATP5F1C UCEC 0.0074 high
ENSG00000165629 ATP5F1C LUSC 0.015 low
ENSG00000165629 ATP5F1C LUAD 0.02 high
ENSG00000165629 ATP5F1C PCPG 0.0018 high
ENSG00000165629 ATP5F1C THYM 0.0071 low
ENSG00000165629 ATP5F1C BRCA 0.013 high
ENSG00000165629 ATP5F1C COAD 0.046 low
ENSG00000165629 ATP5F1C ESCA 0.0024 high
ENSG00000165629 ATP5F1C OV 8e-04 low
ENSG00000165629 ATP5F1C BLCA 0.04 low
ENSG00000165629 ATP5F1C LAML 0.0026 high
ENSG00000165629 ATP5F1C GBM 0.029 low
ENSG00000165629 ATP5F1C LIHC 0.02 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000165629 ATP5F1C LUSC Del 1.096940 0.071528 0.369886 0.425150
ENSG00000165629 ATP5F1C LUAD Del 0.733848 0.051615 0.311437 0.236434
ENSG00000165629 ATP5F1C LGG Amp 1.580338 0.057035 0.716971 0.124756
ENSG00000165629 ATP5F1C BLCA Amp 12.095380 0.428312 0.734605 0.441176
ENSG00000165629 ATP5F1C BRCA Amp 2.266807 0.174400 0.628724 0.276852