Ensembl ID ENSG00000165392 Gene ID 7486 Accession 12791
Gene Symbol WRN Alias RECQ3;RECQL2;RECQL3 Full Name WRN RecQ like helicase
Position 8 : 31033788 - 31176138 Length 142351 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

ENSG00000165392 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000165392 1.13 1.30e-13 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000165392 vulvar cancer 10206685
ENSG00000165392 cancer 10364153
ENSG00000165392 cancer 10506209
ENSG00000165392 cancer 10606667
ENSG00000165392 cancer 11032027
ENSG00000165392 cancer 11138010
ENSG00000165392 cancer 11275547
ENSG00000165392 cancer 11427532
ENSG00000165392 cancer 11452021
ENSG00000165392 cancer 11717307
ENSG00000165392 cancer 11765063
ENSG00000165392 cancer 11979727
ENSG00000165392 cancer 12242278
ENSG00000165392 cancer 12478586
ENSG00000165392 cancer 12483516
ENSG00000165392 cancer 12488583
ENSG00000165392 cancers 12595564
ENSG00000165392 cancer 12771022
ENSG00000165392 tumor 12827497
ENSG00000165392 cancer 12842909
ENSG00000165392 cancer 12934712
ENSG00000165392 cancer 12937274
ENSG00000165392 cancers 14657658
ENSG00000165392 cancer 14712220
ENSG00000165392 cancer 15084309
ENSG00000165392 cancer 15135730
ENSG00000165392 tumor 15149862
ENSG00000165392 cancer 15235603
ENSG00000165392 tumor 15355988
ENSG00000165392 cancer 15498034
ENSG00000165392 cancer 15735006
ENSG00000165392 cancer 15743673
ENSG00000165392 cancer 15889139
ENSG00000165392 cancer 15964827
ENSG00000165392 cancer 16030011
ENSG00000165392 cancer 16246145
ENSG00000165392 cancer 16362795
ENSG00000165392 cancer 16405962
ENSG00000165392 cancer 16412221
ENSG00000165392 familial breast cancer 16501249
ENSG00000165392 cancer 16503984
ENSG00000165392 tumor 16584908
ENSG00000165392 cancer 16622405
ENSG00000165392 tumour 16636668
ENSG00000165392 ovarian cancer 16714450
ENSG00000165392 cancer 16720342
ENSG00000165392 tumor 16723399
ENSG00000165392 DLBCL 16738949
ENSG00000165392 cancer 16798775
ENSG00000165392 cancer 17115688
ENSG00000165392 cancer 17156731
ENSG00000165392 breast cancer 17301258
ENSG00000165392 cancer 17314245
ENSG00000165392 cancer 17364146
ENSG00000165392 tumors 17372756
ENSG00000165392 familial breast cancer 17412712
ENSG00000165392 cancer 17452246
ENSG00000165392 cancer 17541157
ENSG00000165392 cancer 17623900
ENSG00000165392 tumor 17624410
ENSG00000165392 cancer 17717003
ENSG00000165392 breast cancer 17764108
ENSG00000165392 cancers 17875398
ENSG00000165392 cancer 17917271
ENSG00000165392 cancer 17996922
ENSG00000165392 cancer 18003859
ENSG00000165392 tumor 18006573
ENSG00000165392 cancer 18074021
ENSG00000165392 cancer 18083760
ENSG00000165392 colorectal cancer 18084250
ENSG00000165392 cancer 18195102
ENSG00000165392 cancer 18203716
ENSG00000165392 tumors 18204436
ENSG00000165392 cancers 18250621
ENSG00000165392 cancer 18312465
ENSG00000165392 cancer 18414032
ENSG00000165392 cancer 18430459
ENSG00000165392 cancer 18504617
ENSG00000165392 cancer 18583366
ENSG00000165392 cancer 18616953
ENSG00000165392 cancer 18719387
ENSG00000165392 cancer 18722555
ENSG00000165392 tumor 18805512
ENSG00000165392 colon cancers 18832519
ENSG00000165392 cancer 18852298
ENSG00000165392 colorectal cancers 19002263
ENSG00000165392 cancer 19083132
ENSG00000165392 breast cancer 19205873
ENSG00000165392 tumors 19236379
ENSG00000165392 cancer 19283071
ENSG00000165392 cancer 19372586
ENSG00000165392 cancer 19487340
ENSG00000165392 cancer 19572017
ENSG00000165392 cancer 19628477
ENSG00000165392 cancer 19657341
ENSG00000165392 Tumors 19686742
ENSG00000165392 cancer 19812417
ENSG00000165392 cancer 19906698
ENSG00000165392 Colorectal cancer 19945966
ENSG00000165392 cancer 20075015
ENSG00000165392 cancer 20081208
ENSG00000165392 cancer 20097625
ENSG00000165392 cancer 20445776
ENSG00000165392 cancer 20451470
ENSG00000165392 cancer 20600238
ENSG00000165392 pancreatic cancer 20657174
ENSG00000165392 cancer 20663905
ENSG00000165392 cancer 20691646
ENSG00000165392 rectal cancers 21037082
ENSG00000165392 cancer 21107010
ENSG00000165392 tumor 21151896
ENSG00000165392 cancer 21215367
ENSG00000165392 Cancer 21220316
ENSG00000165392 tumor 21267443
ENSG00000165392 cancers 21365542
ENSG00000165392 cancer 21389352
ENSG00000165392 cancer 21436139
ENSG00000165392 cancer 21549004
ENSG00000165392 cancers 21571861
ENSG00000165392 colon cancers 21738611
ENSG00000165392 cancer 21752281
ENSG00000165392 tumour 21786128
ENSG00000165392 AML 21942242
ENSG00000165392 cancer 21963973
ENSG00000165392 cancer 21977309
ENSG00000165392 prostate cancer 22037268
ENSG00000165392 Esophageal cancer 22173703
ENSG00000165392 tumor 22301954
ENSG00000165392 cancer 22351772
ENSG00000165392 cancer 22390926
ENSG00000165392 cancer 22410776
ENSG00000165392 cancer 22467216
ENSG00000165392 cancer 22544709
ENSG00000165392 tumor 22545052
ENSG00000165392 cancer 22576367
ENSG00000165392 anaplastic thyroid cancer 22654876
ENSG00000165392 tumor 22682314
ENSG00000165392 cancer 22689923
ENSG00000165392 cancer 22713343
ENSG00000165392 cancers 22778947
ENSG00000165392 cervical cancer 22797812
ENSG00000165392 cancer 22871734
ENSG00000165392 tumours 23036272
ENSG00000165392 cancer 23050038
ENSG00000165392 cancer 23050959
ENSG00000165392 cancer 23161009
ENSG00000165392 colon cancer 23566654
ENSG00000165392 cancer 23627586
ENSG00000165392 cancer 23650516
ENSG00000165392 cancer 23867477
ENSG00000165392 cancer 23894508
ENSG00000165392 tumor 23933816
ENSG00000165392 cancer 24036544
ENSG00000165392 gastric cancer 24119900
ENSG00000165392 tumor 24308539
ENSG00000165392 tumors 24356923
ENSG00000165392 gastric cancer 24359226
ENSG00000165392 cancers 24608430
ENSG00000165392 breast cancer 24705211
ENSG00000165392 cancer 24709634
ENSG00000165392 tumor 24709898
ENSG00000165392 cancer 24757718
ENSG00000165392 inherited cancer syndromes 24758503
ENSG00000165392 cancer 24880691
ENSG00000165392 Jejunal Cancer 25018888
ENSG00000165392 cancer 25198671
ENSG00000165392 cancer 25352544
ENSG00000165392 cancer 25400656
ENSG00000165392 Cancer 25468760
ENSG00000165392 cancer 25545408
ENSG00000165392 cancer 25555679
ENSG00000165392 cancers 25620975
ENSG00000165392 cancer 25729389
ENSG00000165392 cancer 25730140
ENSG00000165392 cancer 25801465
ENSG00000165392 tumor 25810110
ENSG00000165392 cancer 25906194
ENSG00000165392 breast cancer 25923920
ENSG00000165392 cancer 25945795
ENSG00000165392 cancer 26037922
ENSG00000165392 Cancer 26241669
ENSG00000165392 breast cancer 26296701
ENSG00000165392 cancer 26455304
ENSG00000165392 breast cancers 26459098
ENSG00000165392 Breast Cancer 26690424
ENSG00000165392 cancers 26808708
ENSG00000165392 cancer 26877874
ENSG00000165392 breast cancer 26959889
ENSG00000165392 cancer 26967246
ENSG00000165392 cancer 27034008
ENSG00000165392 Metastatic Colorectal Cancer 27121793
ENSG00000165392 tumor 27411922
ENSG00000165392 cancer 27413734
ENSG00000165392 breast cancer 27449045
ENSG00000165392 cancer 27471552
ENSG00000165392 tumor 27559010
ENSG00000165392 breast cancer 27571987
ENSG00000165392 cancer 27764811
ENSG00000165392 cancer 27859906
ENSG00000165392 cancers 27863399
ENSG00000165392 cancer 27902925
ENSG00000165392 cancer 27931782
ENSG00000165392 tumor 28092266
ENSG00000165392 breast cancers 28254786
ENSG00000165392 cancer 28276523
ENSG00000165392 bone tumors 28421271
ENSG00000165392 Cancer 28440612
ENSG00000165392 tumor 28494349
ENSG00000165392 breast cancer 28977883
ENSG00000165392 cancer 29043077
ENSG00000165392 cancer 29080750
ENSG00000165392 cancer 29084988
ENSG00000165392 Tumor 29581016
ENSG00000165392 cancer 29616805
ENSG00000165392 tumors 29755661
ENSG00000165392 cancer 29774115
ENSG00000165392 cancer 29998112
ENSG00000165392 tumors 30107528
ENSG00000165392 cancer 30137433
ENSG00000165392 tumors 30234181
ENSG00000165392 cancer 30400178
ENSG00000165392 tumor 30431131
ENSG00000165392 tumors 30487607
ENSG00000165392 cancer 30532073
ENSG00000165392 tumor 30562637
ENSG00000165392 breast cancer 30584360
ENSG00000165392 cancer 30584990
ENSG00000165392 cancer 30625228
ENSG00000165392 cancer 30657978
ENSG00000165392 cancers 30678288
ENSG00000165392 tumors 30703342
ENSG00000165392 cancers 30890607
ENSG00000165392 cancer 30898619
ENSG00000165392 endometrial cancer 30910006
ENSG00000165392 cancers 30971823
ENSG00000165392 cancer 30971826
ENSG00000165392 cancer 31114910
ENSG00000165392 tumor 31119048
ENSG00000165392 cancer 31210839
ENSG00000165392 breast cancer 31333776
ENSG00000165392 tumors 31341965
ENSG00000165392 tumors 31360874
ENSG00000165392 breast cancer 31409076
ENSG00000165392 cancer 31570747
ENSG00000165392 cancer 31772289
ENSG00000165392 cancer 8722214
ENSG00000165392 cancer 8913739
ENSG00000165392 tumor 9885239
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000165392 prostate adenocarcinoma sequence_alteration 4.402% (64/1454) 1 entry
ENSG00000165392 prostate adenocarcinoma missense_variant 4.402% (64/1454) 1 entry
ENSG00000165392 colorectal adenocarcinoma stop_gained 6.516% (78/1197) 2 entries
ENSG00000165392 colorectal adenocarcinoma missense_variant 6.516% (78/1197) 3 entries
ENSG00000165392 esophageal adenocarcinoma sequence_alteration 7.534% (33/438) 1 entry
ENSG00000165392 colorectal adenocarcinoma sequence_alteration 6.516% (78/1197) 2 entries
ENSG00000165392 breast ductal adenocarcinoma sequence_alteration 8.104% (50/617) 1 entry
ENSG00000165392 prostate carcinoma sequence_alteration 2.062% (10/485) 1 entry
ENSG00000165392 colon adenocarcinoma frameshift_variant 3.117% (24/770) 1 entry
ENSG00000165392 bladder transitional cell carcinoma missense_variant 1.46% (2/137) 1 entry
ENSG00000165392 skin melanoma missense_variant 2.585% (25/967) 5 entries
ENSG00000165392 oral squamous cell carcinoma frameshift_variant 2.871% (6/209) 1 entry
ENSG00000165392 brain glioblastoma sequence_alteration 0.324% (3/926) 2 entries
ENSG00000165392 breast ductal adenocarcinoma missense_variant 8.104% (50/617) 1 entry
ENSG00000165392 laryngeal squamous cell carcinoma missense_variant 7.692% (2/26) 1 entry
ENSG00000165392 esophageal squamous cell carcinoma missense_variant 1.329% (9/677) 3 entries
ENSG00000165392 esophageal adenocarcinoma stop_gained 7.534% (33/438) 1 entry
ENSG00000165392 melanoma sequence_alteration 5.941% (6/101) 2 entries
ENSG00000165392 squamous cell lung carcinoma missense_variant 1.818% (15/825) 1 entry
ENSG00000165392 basal cell carcinoma missense_variant 5.172% (3/58) 1 entry
ENSG00000165392 prostate carcinoma frameshift_variant 2.062% (10/485) 1 entry
ENSG00000165392 clear cell renal carcinoma missense_variant 0.4917% (8/1627) 1 entry
ENSG00000165392 colon adenocarcinoma missense_variant 3.117% (24/770) 6 entries
ENSG00000165392 clear cell renal carcinoma sequence_alteration 0.4917% (8/1627) 1 entry
ENSG00000165392 colon adenocarcinoma sequence_alteration 3.117% (24/770) 2 entries
ENSG00000165392 esophageal adenocarcinoma missense_variant 7.534% (33/438) 1 entry
ENSG00000165392 hepatocellular carcinoma missense_variant 0.9989% (9/901) 2 entries
ENSG00000165392 small cell lung carcinoma missense_variant 1.548% (5/323) 2 entries
ENSG00000165392 cecum adenocarcinoma missense_variant 1.515% (2/132) 2 entries
ENSG00000165392 prostate carcinoma missense_variant 2.062% (10/485) 2 entries
ENSG00000165392 head and neck squamous cell carcinoma missense_variant 0.8043% (6/746) 1 entry
ENSG00000165392 central nervous system primitive neuroectodermal neoplasm sequence_alteration 1.126% (5/444) 1 entry
ENSG00000165392 squamous cell lung carcinoma sequence_alteration 1.818% (15/825) 1 entry
ENSG00000165392 Cervical Small Cell Carcinoma missense_variant 33.33% (2/6) 1 entry
ENSG00000165392 ependymoma sequence_alteration 4.348% (2/46) 1 entry
ENSG00000165392 hemangioblastoma sequence_alteration 9.375% (3/32) 1 entry
ENSG00000165392 Gallbladder Adenocarcinoma missense_variant 2.299% (2/87) 2 entries
ENSG00000165392 melanoma conservative_inframe_deletion 5.941% (6/101) 1 entry
ENSG00000165392 oral squamous cell carcinoma missense_variant 2.871% (6/209) 3 entries
ENSG00000165392 colon adenocarcinoma stop_gained 3.117% (24/770) 2 entries
ENSG00000165392 head and neck squamous cell carcinoma sequence_alteration 0.8043% (6/746) 1 entry
ENSG00000165392 ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000165392 lung adenocarcinoma missense_variant 2.049% (25/1220) 3 entries
ENSG00000165392 central nervous system primitive neuroectodermal neoplasm missense_variant 1.126% (5/444) 1 entry
ENSG00000165392 Pleural Epithelioid Mesothelioma missense_variant 0.6329% (1/158) 1 entry
ENSG00000165392 esophageal squamous cell carcinoma frameshift_variant 1.329% (9/677) 1 entry
ENSG00000165392 nasopharyngeal squamous cell carcinoma stop_gained 1.198% (2/167) 1 entry
ENSG00000165392 rectal adenocarcinoma missense_variant 0.4367% (1/229) 1 entry
ENSG00000165392 Parathyroid Gland Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000165392 mucosal melanoma missense_variant 7.143% (1/14) 1 entry
ENSG00000165392 small cell lung carcinoma stop_gained 1.548% (5/323) 1 entry
ENSG00000165392 large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000165392 HER2 Positive Breast Carcinoma missense_variant 5.495% (10/182) 1 entry
ENSG00000165392 polycythemia vera missense_variant 2.083% (1/48) 1 entry
ENSG00000165392 colon carcinoma missense_variant 12.5% (1/8) 1 entry
ENSG00000165392 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000165392 prostate carcinoma stop_gained 2.062% (10/485) 1 entry
ENSG00000165392 Unclassified Renal Cell Carcinoma sequence_alteration 3.846% (1/26) 1 entry
ENSG00000165392 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000165392 melanoma stop_gained 5.941% (6/101) 1 entry
ENSG00000165392 hairy cell leukemia missense_variant 4.762% (1/21) 1 entry
ENSG00000165392 adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000165392 clear cell renal carcinoma stop_gained 0.4917% (8/1627) 1 entry
ENSG00000165392 lung adenocarcinoma stop_gained 2.049% (25/1220) 1 entry
ENSG00000165392 Merkel cell skin cancer sequence_alteration 6.667% (2/30) 1 entry
ENSG00000165392 renal carcinoma missense_variant 14.29% (1/7) 1 entry
ENSG00000165392 nasopharyngeal squamous cell carcinoma missense_variant 1.198% (2/167) 1 entry
ENSG00000165392 non-small cell lung carcinoma missense_variant 1.613% (1/62) 1 entry
ENSG00000165392 skin melanoma sequence_alteration 2.585% (25/967) 1 entry
ENSG00000165392 melanoma missense_variant 5.941% (6/101) 1 entry
ENSG00000165392 osteosarcoma sequence_alteration 0.8621% (1/116) 1 entry
ENSG00000165392 gastric intestinal type adenocarcinoma frameshift_variant 3.529% (3/85) 1 entry
ENSG00000165392 gastric intestinal type adenocarcinoma conservative_inframe_deletion 3.529% (3/85) 1 entry
ENSG00000165392 Merkel cell skin cancer missense_variant 6.667% (2/30) 1 entry
ENSG00000165392 hemangioblastoma missense_variant 9.375% (3/32) 1 entry
ENSG00000165392 small cell lung carcinoma sequence_alteration 1.548% (5/323) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000165392 MESO 0.0022 high
ENSG00000165392 STAD 0.019 low
ENSG00000165392 PAAD 0.014 high
ENSG00000165392 UCEC 0.029 high
ENSG00000165392 THCA 0.008 high
ENSG00000165392 ACC 0.031 high
ENSG00000165392 LGG 1e-04 high
ENSG00000165392 HNSC 0.017 low
ENSG00000165392 READ 0.0047 low
ENSG00000165392 KIRP 0.00032 high
ENSG00000165392 THYM 0.021 low
ENSG00000165392 COAD 0.0023 low
ENSG00000165392 ESCA 0.036 low
ENSG00000165392 OV 0.021 low
ENSG00000165392 KIRC 0.0089 low
ENSG00000165392 LAML 0.00039 low
ENSG00000165392 LIHC 0.00092 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000165392 LUSC Del 0.839359 0.067639 0.440535 0.626747
ENSG00000165392 LUAD Del 1.001255 0.055601 0.449199 0.498062
ENSG00000165392 READ Del 1.944011 0.103016 0.657755 0.557576
ENSG00000165392 COAD Del 2.472621 0.060734 0.661991 0.399113
ENSG00000165392 UCS Del 0.834845 0.212663 0.635762 0.500000
ENSG00000165392 LIHC Del 1.113594 0.072567 0.702095 0.672973
ENSG00000165392 BLCA Del 1.046542 0.083322 0.504403 0.585784
ENSG00000165392 BRCA Del 4.091931 0.087815 0.576956 0.485185
ENSG00000165392 PRAD Del 2.713788 0.095502 0.576446 0.459350
ENSG00000165392 UCEC Del 1.186609 0.054233 0.653799 0.192950
ENSG00000165392 OV Del 3.567618 0.227749 0.732763 0.595855