Ensembl ID ENSG00000164104 Gene ID 3148 Accession 5000
Gene Symbol HMGB2 Alias HMG2 Full Name high mobility group box 2
Position 4 : 173331376 - 173334391 Length 3016 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

ENSG00000164104 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000164104 HMGB2 1.12 1.16e-42 BRCA
ENSG00000164104 HMGB2 1.30 1.03e-34 LUSC
ENSG00000164104 HMGB2 2.23 1.84e-14 GBM
ENSG00000164104 HMGB2 1.37 1.08e-25 LIHC
ENSG00000164104 HMGB2 0.86 1.53e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000164104 HMGB2 non-small cell lung cancer 10076573
ENSG00000164104 HMGB2 tumors 12032302
ENSG00000164104 HMGB2 tumour 14724156
ENSG00000164104 HMGB2 ovarian cancer 16036111
ENSG00000164104 HMGB2 tumors 16823850
ENSG00000164104 HMGB2 cancer 19240692
ENSG00000164104 HMGB2 tumor 19893615
ENSG00000164104 HMGB2 tumor 20851854
ENSG00000164104 HMGB2 colorectal cancer 23255232
ENSG00000164104 HMGB2 tumor 23426143
ENSG00000164104 HMGB2 GBM 23828241
ENSG00000164104 HMGB2 tumor 23969227
ENSG00000164104 HMGB2 renal cancer 24078503
ENSG00000164104 HMGB2 tumors 24479488
ENSG00000164104 HMGB2 bladder cancer 24571540
ENSG00000164104 HMGB2 lung cancer 24684392
ENSG00000164104 HMGB2 tumor 25060178
ENSG00000164104 HMGB2 breast cancer 25284587
ENSG00000164104 HMGB2 tumors 25327479
ENSG00000164104 HMGB2 cancer 25653540
ENSG00000164104 HMGB2 gastric cancer 25996293
ENSG00000164104 HMGB2 tumor 26337976
ENSG00000164104 HMGB2 prostate cancers 26682011
ENSG00000164104 HMGB2 tumor 27863459
ENSG00000164104 HMGB2 pancreatic cancer 28069585
ENSG00000164104 HMGB2 gastric cancer 28396617
ENSG00000164104 HMGB2 breast cancer 29050221
ENSG00000164104 HMGB2 liver tumor 29218329
ENSG00000164104 HMGB2 breast cancer 29463261
ENSG00000164104 HMGB2 colorectal cancers 29487276
ENSG00000164104 HMGB2 cancer 29721183
ENSG00000164104 HMGB2 ovarian cancer 29888106
ENSG00000164104 HMGB2 gastric cancer 30296520
ENSG00000164104 HMGB2 tumor 30575817
ENSG00000164104 HMGB2 prostate cancer 30674244
ENSG00000164104 HMGB2 cancer 30988666
ENSG00000164104 HMGB2 cervical cancer 31209930
ENSG00000164104 HMGB2 gastric cancer 31621076
ENSG00000164104 HMGB2 tumor 31661640
ENSG00000164104 HMGB2 tumor 31694235
ENSG00000164104 HMGB2 tumor 31695969
ENSG00000164104 HMGB2 tumor 8616907
ENSG00000164104 HMGB2 cancer 8975778
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000164104 HMGB2 STAD 0.018 low
ENSG00000164104 HMGB2 UVM 0.004 high
ENSG00000164104 HMGB2 PAAD 8e-04 high
ENSG00000164104 HMGB2 THCA 0.029 high
ENSG00000164104 HMGB2 LUSC 0.027 low
ENSG00000164104 HMGB2 HNSC 0.015 high
ENSG00000164104 HMGB2 KIRP 0.00014 high
ENSG00000164104 HMGB2 LUAD 0.013 high
ENSG00000164104 HMGB2 THYM 0.0075 low
ENSG00000164104 HMGB2 UCS 0.0037 low
ENSG00000164104 HMGB2 ESCA 0.023 high
ENSG00000164104 HMGB2 OV 0.03 low
ENSG00000164104 HMGB2 DLBC 0.041 low
ENSG00000164104 HMGB2 TGCT 0.029 low
ENSG00000164104 HMGB2 BLCA 0.01 low
ENSG00000164104 HMGB2 LAML 0.0036 low
ENSG00000164104 HMGB2 SKCM 0.0016 low
ENSG00000164104 HMGB2 CESC 0.015 low
ENSG00000164104 HMGB2 LIHC 0.00021 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000164104 HMGB2 LUSC Del 11.696576 0.160993 0.401161 0.668663
ENSG00000164104 HMGB2 LUAD Del 5.966560 0.100082 0.313430 0.360465
ENSG00000164104 HMGB2 LGG Del 10.319233 0.105944 0.467530 0.255361
ENSG00000164104 HMGB2 CESC Del 2.162335 0.093585 0.464725 0.362712
ENSG00000164104 HMGB2 KIRP Del 0.740219 0.027066 0.585346 0.100694
ENSG00000164104 HMGB2 ACC Del 1.275548 0.121497 0.534461 0.166667
ENSG00000164104 HMGB2 COAD Del 6.188298 0.088821 0.437893 0.321508
ENSG00000164104 HMGB2 SARC Del 4.205238 0.202628 0.489844 0.322957
ENSG00000164104 HMGB2 GBM Del 1.794513 0.065109 0.446280 0.140381
ENSG00000164104 HMGB2 ESCA Del 1.683171 0.124152 0.419278 0.532609
ENSG00000164104 HMGB2 SKCM Del 0.756059 0.067260 0.428657 0.256131
ENSG00000164104 HMGB2 HNSC Del 6.488808 0.101628 0.369013 0.360153
ENSG00000164104 HMGB2 LIHC Del 7.497599 0.145426 0.565857 0.440541
ENSG00000164104 HMGB2 BLCA Del 6.546640 0.148864 0.382104 0.411765
ENSG00000164104 HMGB2 BRCA Del 4.906738 0.092125 0.401665 0.312037
ENSG00000164104 HMGB2 STAD Del 10.783017 0.150491 0.369366 0.437642
ENSG00000164104 HMGB2 UCEC Del 1.959666 0.062870 0.467550 0.218924
ENSG00000164104 HMGB2 KIRC Del 0.762468 0.025016 0.328852 0.147727
ENSG00000164104 HMGB2 OV Del 14.791594 0.342185 0.641874 0.696028