Ensembl ID ENSG00000164062 Gene ID 327 Accession 586
Gene Symbol APEH Alias APH;OPH;AARE;ACPH;D3S48E;D3F15S2;DNF15S2 Full Name acylaminoacyl-peptide hydrolase
Position 3 : 49674014 - 49683971 Length 9958 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]

ENSG00000164062 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000164062 -1.2 1.04e-48 KIRC
ENSG00000164062 0.63 1.31e-27 BRCA
ENSG00000164062 1.08 2.02e-21 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000164062 tumor 1328432
ENSG00000164062 tumors 20101222
ENSG00000164062 cancer 21286310
ENSG00000164062 turban tumor syndrome 21931648
ENSG00000164062 cancer 22016782
ENSG00000164062 Breast cancer 22703841
ENSG00000164062 pancreatic cancer 23903680
ENSG00000164062 tumors 24040417
ENSG00000164062 cancer 24260504
ENSG00000164062 prostate cancer 24512522
ENSG00000164062 cancers 24829522
ENSG00000164062 tumor 25070035
ENSG00000164062 prostate tumors 25234292
ENSG00000164062 tumor 25290917
ENSG00000164062 cancer 25733714
ENSG00000164062 tumor 27659522
ENSG00000164062 cancer 27669226
ENSG00000164062 tumor 29717201
ENSG00000164062 neck cancer 30038710
ENSG00000164062 colon cancer 31040701
ENSG00000164062 pancreatic cancer 31266814
ENSG00000164062 uterine cervical cancer 8099726
ENSG00000164062 small cell lung cancer 8724851
ENSG00000164062 cancer 9401002
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000164062 STAD 0.023 low
ENSG00000164062 CHOL 0.01 low
ENSG00000164062 THCA 0.0087 low
ENSG00000164062 LGG 0.024 low
ENSG00000164062 READ 0.028 low
ENSG00000164062 KICH 0.0072 high
ENSG00000164062 PCPG 0.00014 low
ENSG00000164062 THYM 0.04 low
ENSG00000164062 COAD 0.033 high
ENSG00000164062 UCS 0.0023 high
ENSG00000164062 OV 0.041 low
ENSG00000164062 DLBC 0.012 low
ENSG00000164062 KIRC 0.0099 low
ENSG00000164062 BLCA 0.0021 high
ENSG00000164062 LAML 0.00032 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000164062 CHOL Del 1.097134 0.240589 0.628335 0.833333
ENSG00000164062 LUSC Del 3.885326 0.103079 0.412217 0.866267
ENSG00000164062 LUAD Del 1.500701 0.061896 0.324215 0.476744
ENSG00000164062 LGG Del 2.366814 0.055504 0.522236 0.091618
ENSG00000164062 CESC Del 0.783919 0.068629 0.540290 0.406780
ENSG00000164062 COAD Del 2.074602 0.056893 0.432284 0.161863
ENSG00000164062 UCS Del 1.658342 0.284196 0.516178 0.607143
ENSG00000164062 SARC Del 2.067024 0.158817 0.538740 0.249027
ENSG00000164062 ESCA Del 2.523689 0.146511 0.448421 0.663043
ENSG00000164062 HNSC Del 0.960210 0.057451 0.434874 0.720307
ENSG00000164062 DLBC Del 0.877754 0.133076 0.462386 0.187500
ENSG00000164062 BLCA Del 6.300843 0.146742 0.412560 0.296569
ENSG00000164062 BRCA Del 29.441436 0.175429 0.462378 0.319444
ENSG00000164062 STAD Del 6.606969 0.121767 0.350494 0.335601
ENSG00000164062 UCEC Del 1.411195 0.057045 0.487793 0.131725
ENSG00000164062 MESO Del 16.704211 0.533858 0.567339 0.505747
ENSG00000164062 KIRC Del 50.963058 0.180032 0.515991 0.878788
ENSG00000164062 OV Del 1.491018 0.192783 0.482351 0.319516