Ensembl ID ENSG00000163655 Gene ID 8833 Accession 4378
Gene Symbol GMPS Alias GATD7 Full Name guanine monophosphate synthase
Position 3 : 155870650 - 155944020 Length 73371 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

ENSG00000163655 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000163655 GMPS 0.81 4.12e-20 HNSC
ENSG00000163655 GMPS 0.64 7.56e-28 BRCA
ENSG00000163655 GMPS 0.90 5.55e-44 COAD
ENSG00000163655 GMPS 1.12 7.28e-17 KICH
ENSG00000163655 GMPS 1.73 2.87e-73 LUSC
ENSG00000163655 GMPS 0.55 2.07e-13 LIHC
ENSG00000163655 GMPS 0.65 9.34e-13 STAD
ENSG00000163655 GMPS 0.66 5.67e-16 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000163655 GMPS cancer 18925772
ENSG00000163655 GMPS breast cancer 22552268
ENSG00000163655 GMPS tumors 23078675
ENSG00000163655 GMPS cancer 2424286
ENSG00000163655 GMPS breast cancer 26067754
ENSG00000163655 GMPS Liver Cancer 27939741
ENSG00000163655 GMPS tumors 29257071
ENSG00000163655 GMPS ovarian cancer 30701134
ENSG00000163655 GMPS tumors 612712
ENSG00000163655 GMPS kidney tumor 6260205
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000163655 GMPS gastric adenocarcinoma missense_variant 1.075% (6/558) 1 entry
ENSG00000163655 GMPS pancreatic ductal adenocarcinoma sequence_alteration 2.462% (31/1259) 1 entry
ENSG00000163655 GMPS breast ductal adenocarcinoma sequence_alteration 7.534% (44/584) 1 entry
ENSG00000163655 GMPS breast carcinoma missense_variant 0.4961% (7/1411) 1 entry
ENSG00000163655 GMPS pancreatic ductal adenocarcinoma missense_variant 2.462% (31/1259) 2 entries
ENSG00000163655 GMPS melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000163655 GMPS gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 2 entries
ENSG00000163655 GMPS cecum adenocarcinoma missense_variant 3.2% (4/125) 1 entry
ENSG00000163655 GMPS chronic myelomonocytic leukemia missense_variant 2.105% (2/95) 1 entry
ENSG00000163655 GMPS colon adenocarcinoma sequence_alteration 1.524% (11/722) 2 entries
ENSG00000163655 GMPS papillary renal cell carcinoma missense_variant 0.5634% (2/355) 1 entry
ENSG00000163655 GMPS colon adenocarcinoma missense_variant 1.524% (11/722) 4 entries
ENSG00000163655 GMPS skin melanoma missense_variant 0.8273% (8/967) 1 entry
ENSG00000163655 GMPS esophageal squamous cell carcinoma missense_variant 0.7407% (5/675) 2 entries
ENSG00000163655 GMPS head and neck squamous cell carcinoma sequence_alteration 0.5362% (4/746) 1 entry
ENSG00000163655 GMPS chronic myelomonocytic leukemia sequence_alteration 2.105% (2/95) 1 entry
ENSG00000163655 GMPS prostate carcinoma sequence_alteration 0.939% (4/426) 1 entry
ENSG00000163655 GMPS small cell lung carcinoma sequence_alteration 0.9434% (3/318) 2 entries
ENSG00000163655 GMPS hemangioblastoma sequence_alteration 6.25% (2/32) 1 entry
ENSG00000163655 GMPS prostate adenocarcinoma sequence_alteration 1.857% (27/1454) 1 entry
ENSG00000163655 GMPS colorectal adenocarcinoma sequence_alteration 2.46% (28/1138) 1 entry
ENSG00000163655 GMPS colorectal adenocarcinoma missense_variant 2.46% (28/1138) 2 entries
ENSG00000163655 GMPS lung adenocarcinoma missense_variant 0.7739% (9/1163) 2 entries
ENSG00000163655 GMPS ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000163655 GMPS squamous cell lung carcinoma sequence_alteration 0.3937% (3/762) 1 entry
ENSG00000163655 GMPS clear cell renal carcinoma missense_variant 0.2177% (3/1378) 3 entries
ENSG00000163655 GMPS female breast carcinoma missense_variant 0.3745% (1/267) 1 entry
ENSG00000163655 GMPS colorectal adenoma missense_variant 11.11% (1/9) 1 entry
ENSG00000163655 GMPS embryonal rhabdomyosarcoma missense_variant 1.316% (1/76) 1 entry
ENSG00000163655 GMPS ovarian serous adenocarcinoma stop_gained 0.4458% (3/673) 1 entry
ENSG00000163655 GMPS non-small cell lung carcinoma sequence_alteration 1.887% (1/53) 1 entry
ENSG00000163655 GMPS Pleural Biphasic Mesothelioma sequence_alteration 1.449% (1/69) 1 entry
ENSG00000163655 GMPS squamous cell lung carcinoma missense_variant 0.3937% (3/762) 1 entry
ENSG00000163655 GMPS non-small cell lung carcinoma missense_variant 1.887% (1/53) 1 entry
ENSG00000163655 GMPS pharyngeal squamous cell carcinoma sequence_alteration 3.226% (1/31) 1 entry
ENSG00000163655 GMPS medulloblastoma sequence_alteration 4.167% (1/24) 1 entry
ENSG00000163655 GMPS prostate carcinoma missense_variant 0.939% (4/426) 1 entry
ENSG00000163655 GMPS colorectal adenocarcinoma stop_gained 2.46% (28/1138) 1 entry
ENSG00000163655 GMPS small cell lung carcinoma missense_variant 0.9434% (3/318) 1 entry
ENSG00000163655 GMPS Merkel cell skin cancer missense_variant 3.333% (1/30) 1 entry
ENSG00000163655 GMPS neoplasm of mature B-cells missense_variant 2.941% (1/34) 1 entry
ENSG00000163655 GMPS Pleural Epithelioid Mesothelioma missense_variant 0.6329% (1/158) 1 entry
ENSG00000163655 GMPS bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000163655 GMPS colon adenocarcinoma stop_gained 1.524% (11/722) 1 entry
ENSG00000163655 GMPS oral squamous cell carcinoma conservative_inframe_deletion 0.4878% (1/205) 1 entry
ENSG00000163655 GMPS basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000163655 GMPS head and neck squamous cell carcinoma missense_variant 0.5362% (4/746) 1 entry
ENSG00000163655 GMPS Pleural Biphasic Mesothelioma missense_variant 1.449% (1/69) 1 entry
ENSG00000163655 GMPS pharyngeal squamous cell carcinoma missense_variant 3.226% (1/31) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000163655 GMPS MESO 1e-04 high
ENSG00000163655 GMPS SARC 0.018 high
ENSG00000163655 GMPS STAD 0.016 low
ENSG00000163655 GMPS UVM 0.00034 low
ENSG00000163655 GMPS PAAD 0.00021 high
ENSG00000163655 GMPS THCA 0.0041 high
ENSG00000163655 GMPS LGG 0.0031 high
ENSG00000163655 GMPS LUSC 0.0082 low
ENSG00000163655 GMPS HNSC 0.011 high
ENSG00000163655 GMPS READ 0.022 low
ENSG00000163655 GMPS KIRP 0.0015 high
ENSG00000163655 GMPS LUAD 0.00027 high
ENSG00000163655 GMPS PCPG 0.031 high
ENSG00000163655 GMPS THYM 0.044 low
ENSG00000163655 GMPS COAD 0.02 low
ENSG00000163655 GMPS UCS 0.018 low
ENSG00000163655 GMPS OV 0.04 low
ENSG00000163655 GMPS DLBC 0.014 low
ENSG00000163655 GMPS KIRC 0.0016 high
ENSG00000163655 GMPS PRAD 0.01 low
ENSG00000163655 GMPS BLCA 0.013 high
ENSG00000163655 GMPS SKCM 0.025 low
ENSG00000163655 GMPS CESC 0.027 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000163655 GMPS LUSC Amp 53.605289 0.927709 0.976919 0.846307
ENSG00000163655 GMPS LUAD Amp 1.127135 0.128817 0.440665 0.269380
ENSG00000163655 GMPS CESC Amp 15.816228 0.475899 1.005877 0.718644
ENSG00000163655 GMPS ESCA Amp 8.719068 0.620821 0.862772 0.614130
ENSG00000163655 GMPS HNSC Amp 26.180605 0.466953 0.734739 0.691571
ENSG00000163655 GMPS PCPG Del 0.856815 0.061484 0.630659 0.580247
ENSG00000163655 GMPS BRCA Amp 1.133104 0.154377 0.514698 0.279630
ENSG00000163655 GMPS STAD Amp 1.490264 0.155770 0.481037 0.303855
ENSG00000163655 GMPS PRAD Amp 0.696352 0.045302 0.401508 0.140244
ENSG00000163655 GMPS UCEC Amp 5.226927 0.185729 0.672023 0.239332
ENSG00000163655 GMPS OV Amp 22.469694 0.728592 0.855814 0.716753