Ensembl ID ENSG00000163655 Gene ID 8833 Accession 4378
Gene Symbol GMPS Alias GATD7 Full Name guanine monophosphate synthase
Position 3 : 155870650 - 155944020 Length 73371 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

ENSG00000163655 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000163655 0.81 4.12e-20 HNSC
ENSG00000163655 0.64 7.56e-28 BRCA
ENSG00000163655 0.90 5.55e-44 COAD
ENSG00000163655 1.12 7.28e-17 KICH
ENSG00000163655 1.73 2.87e-73 LUSC
ENSG00000163655 0.55 2.07e-13 LIHC
ENSG00000163655 0.65 9.34e-13 STAD
ENSG00000163655 0.66 5.67e-16 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000163655 cancer 18925772
ENSG00000163655 breast cancer 22552268
ENSG00000163655 tumors 23078675
ENSG00000163655 cancer 2424286
ENSG00000163655 breast cancer 26067754
ENSG00000163655 Liver Cancer 27939741
ENSG00000163655 tumors 29257071
ENSG00000163655 ovarian cancer 30701134
ENSG00000163655 tumors 612712
ENSG00000163655 kidney tumor 6260205
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000163655 gastric adenocarcinoma missense_variant 1.075% (6/558) 1 entry
ENSG00000163655 pancreatic ductal adenocarcinoma sequence_alteration 2.462% (31/1259) 1 entry
ENSG00000163655 breast ductal adenocarcinoma sequence_alteration 7.534% (44/584) 1 entry
ENSG00000163655 breast carcinoma missense_variant 0.4961% (7/1411) 1 entry
ENSG00000163655 pancreatic ductal adenocarcinoma missense_variant 2.462% (31/1259) 2 entries
ENSG00000163655 melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000163655 gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 2 entries
ENSG00000163655 cecum adenocarcinoma missense_variant 3.2% (4/125) 1 entry
ENSG00000163655 chronic myelomonocytic leukemia missense_variant 2.105% (2/95) 1 entry
ENSG00000163655 colon adenocarcinoma sequence_alteration 1.524% (11/722) 2 entries
ENSG00000163655 papillary renal cell carcinoma missense_variant 0.5634% (2/355) 1 entry
ENSG00000163655 colon adenocarcinoma missense_variant 1.524% (11/722) 4 entries
ENSG00000163655 skin melanoma missense_variant 0.8273% (8/967) 1 entry
ENSG00000163655 esophageal squamous cell carcinoma missense_variant 0.7407% (5/675) 2 entries
ENSG00000163655 head and neck squamous cell carcinoma sequence_alteration 0.5362% (4/746) 1 entry
ENSG00000163655 chronic myelomonocytic leukemia sequence_alteration 2.105% (2/95) 1 entry
ENSG00000163655 prostate carcinoma sequence_alteration 0.939% (4/426) 1 entry
ENSG00000163655 small cell lung carcinoma sequence_alteration 0.9434% (3/318) 2 entries
ENSG00000163655 hemangioblastoma sequence_alteration 6.25% (2/32) 1 entry
ENSG00000163655 prostate adenocarcinoma sequence_alteration 1.857% (27/1454) 1 entry
ENSG00000163655 colorectal adenocarcinoma sequence_alteration 2.46% (28/1138) 1 entry
ENSG00000163655 colorectal adenocarcinoma missense_variant 2.46% (28/1138) 2 entries
ENSG00000163655 lung adenocarcinoma missense_variant 0.7739% (9/1163) 2 entries
ENSG00000163655 ovarian serous adenocarcinoma missense_variant 0.4458% (3/673) 1 entry
ENSG00000163655 squamous cell lung carcinoma sequence_alteration 0.3937% (3/762) 1 entry
ENSG00000163655 clear cell renal carcinoma missense_variant 0.2177% (3/1378) 3 entries
ENSG00000163655 female breast carcinoma missense_variant 0.3745% (1/267) 1 entry
ENSG00000163655 colorectal adenoma missense_variant 11.11% (1/9) 1 entry
ENSG00000163655 embryonal rhabdomyosarcoma missense_variant 1.316% (1/76) 1 entry
ENSG00000163655 ovarian serous adenocarcinoma stop_gained 0.4458% (3/673) 1 entry
ENSG00000163655 non-small cell lung carcinoma sequence_alteration 1.887% (1/53) 1 entry
ENSG00000163655 Pleural Biphasic Mesothelioma sequence_alteration 1.449% (1/69) 1 entry
ENSG00000163655 squamous cell lung carcinoma missense_variant 0.3937% (3/762) 1 entry
ENSG00000163655 non-small cell lung carcinoma missense_variant 1.887% (1/53) 1 entry
ENSG00000163655 pharyngeal squamous cell carcinoma sequence_alteration 3.226% (1/31) 1 entry
ENSG00000163655 medulloblastoma sequence_alteration 4.167% (1/24) 1 entry
ENSG00000163655 prostate carcinoma missense_variant 0.939% (4/426) 1 entry
ENSG00000163655 colorectal adenocarcinoma stop_gained 2.46% (28/1138) 1 entry
ENSG00000163655 small cell lung carcinoma missense_variant 0.9434% (3/318) 1 entry
ENSG00000163655 Merkel cell skin cancer missense_variant 3.333% (1/30) 1 entry
ENSG00000163655 neoplasm of mature B-cells missense_variant 2.941% (1/34) 1 entry
ENSG00000163655 Pleural Epithelioid Mesothelioma missense_variant 0.6329% (1/158) 1 entry
ENSG00000163655 bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000163655 colon adenocarcinoma stop_gained 1.524% (11/722) 1 entry
ENSG00000163655 oral squamous cell carcinoma conservative_inframe_deletion 0.4878% (1/205) 1 entry
ENSG00000163655 basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000163655 head and neck squamous cell carcinoma missense_variant 0.5362% (4/746) 1 entry
ENSG00000163655 Pleural Biphasic Mesothelioma missense_variant 1.449% (1/69) 1 entry
ENSG00000163655 pharyngeal squamous cell carcinoma missense_variant 3.226% (1/31) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000163655 MESO 1e-04 high
ENSG00000163655 SARC 0.018 high
ENSG00000163655 STAD 0.016 low
ENSG00000163655 UVM 0.00034 low
ENSG00000163655 PAAD 0.00021 high
ENSG00000163655 THCA 0.0041 high
ENSG00000163655 LGG 0.0031 high
ENSG00000163655 LUSC 0.0082 low
ENSG00000163655 HNSC 0.011 high
ENSG00000163655 READ 0.022 low
ENSG00000163655 KIRP 0.0015 high
ENSG00000163655 LUAD 0.00027 high
ENSG00000163655 PCPG 0.031 high
ENSG00000163655 THYM 0.044 low
ENSG00000163655 COAD 0.02 low
ENSG00000163655 UCS 0.018 low
ENSG00000163655 OV 0.04 low
ENSG00000163655 DLBC 0.014 low
ENSG00000163655 KIRC 0.0016 high
ENSG00000163655 PRAD 0.01 low
ENSG00000163655 BLCA 0.013 high
ENSG00000163655 SKCM 0.025 low
ENSG00000163655 CESC 0.027 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000163655 LUSC Amp 53.605289 0.927709 0.976919 0.846307
ENSG00000163655 LUAD Amp 1.127135 0.128817 0.440665 0.269380
ENSG00000163655 CESC Amp 15.816228 0.475899 1.005877 0.718644
ENSG00000163655 ESCA Amp 8.719068 0.620821 0.862772 0.614130
ENSG00000163655 HNSC Amp 26.180605 0.466953 0.734739 0.691571
ENSG00000163655 PCPG Del 0.856815 0.061484 0.630659 0.580247
ENSG00000163655 BRCA Amp 1.133104 0.154377 0.514698 0.279630
ENSG00000163655 STAD Amp 1.490264 0.155770 0.481037 0.303855
ENSG00000163655 PRAD Amp 0.696352 0.045302 0.401508 0.140244
ENSG00000163655 UCEC Amp 5.226927 0.185729 0.672023 0.239332
ENSG00000163655 OV Amp 22.469694 0.728592 0.855814 0.716753