Ensembl ID ENSG00000163161 Gene ID 2071 Accession 3435
Gene Symbol ERCC3 Alias XPB;BTF2;Ssl2;TTD2;GTF2H;RAD25;TFIIH Full Name ERCC excision repair 3, TFIIH core complex helicase subunit
Position 2 : 127257290 - 127294166 Length 36877 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

ENSG00000163161 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000163161 0.33 4.84e-21 KIRC
ENSG00000163161 0.45 1.01e-22 COAD
ENSG00000163161 0.46 6.76e-19 LUSC
ENSG00000163161 0.74 1.28e-15 CHOL
ENSG00000163161 0.36 1.96e-16 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000163161 cancer 10862089
ENSG00000163161 lung cancer 10910954
ENSG00000163161 ovarian cancer 10948350
ENSG00000163161 ovarian cancer 11077043
ENSG00000163161 ovarian tumors 11689286
ENSG00000163161 cancer 11765063
ENSG00000163161 tumor 12045463
ENSG00000163161 tumor 12359753
ENSG00000163161 tumor 12451985
ENSG00000163161 lung cancer 12969519
ENSG00000163161 epithelial ovarian cancer 14614013
ENSG00000163161 lung cancer 14694596
ENSG00000163161 esophageal cancer 15375507
ENSG00000163161 cancer 15608684
ENSG00000163161 tumor 16452196
ENSG00000163161 lung cancer 16550608
ENSG00000163161 lung cancer 16835333
ENSG00000163161 DLBCL 17255358
ENSG00000163161 cancer 17339330
ENSG00000163161 cancer 18470933
ENSG00000163161 cancer 19114557
ENSG00000163161 tumor 19273283
ENSG00000163161 skin cancers 20223010
ENSG00000163161 cancer 21176161
ENSG00000163161 cancers 21571596
ENSG00000163161 cancer 21592869
ENSG00000163161 epithelial ovarian cancer 21971700
ENSG00000163161 lung cancer 22493747
ENSG00000163161 cancer 23549790
ENSG00000163161 colon cancer 23566654
ENSG00000163161 colorectal cancer 23594796
ENSG00000163161 tumour 23940574
ENSG00000163161 Laryngeal cancer 24582975
ENSG00000163161 cancers 24609361
ENSG00000163161 bladder cancer 25535740
ENSG00000163161 cancer 26074141
ENSG00000163161 pancreatic cancer 26617894
ENSG00000163161 pancreatic cancer 27050953
ENSG00000163161 Tumor 27197304
ENSG00000163161 Pancreatic Cancer 27384421
ENSG00000163161 tumor 27574181
ENSG00000163161 bladder cancer 27626805
ENSG00000163161 Breast Cancer 27655433
ENSG00000163161 gastric cancer 27660469
ENSG00000163161 cancer 27994662
ENSG00000163161 cancer 28050010
ENSG00000163161 cancer 28398229
ENSG00000163161 breast cancer 28423363
ENSG00000163161 cancer 28792271
ENSG00000163161 bladder cancer 28803404
ENSG00000163161 cancer 28902838
ENSG00000163161 colon cancer 29568775
ENSG00000163161 cancer 30227140
ENSG00000163161 tumor 30464628
ENSG00000163161 cancer 30762924
ENSG00000163161 tumor 30854110
ENSG00000163161 gastric cancer 31289483
ENSG00000163161 colon cancer 31516394
ENSG00000163161 tumor 31517177
ENSG00000163161 HNSCCs 31832883
ENSG00000163161 lung cancer 31875816
ENSG00000163161 cancer 31963603
ENSG00000163161 tumor 7585533
ENSG00000163161 cancer 8053936
ENSG00000163161 skin cancer 8194528
ENSG00000163161 cancer 8202161
ENSG00000163161 tumors 8876669
ENSG00000163161 skin cancers 9415314
ENSG00000163161 skin tumor 9427533
ENSG00000163161 cancer 9893669
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000163161 colorectal adenocarcinoma sequence_alteration 2.226% (27/1213) 1 entry
ENSG00000163161 colorectal adenocarcinoma missense_variant 2.226% (27/1213) 2 entries
ENSG00000163161 pancreatic ductal adenocarcinoma stop_gained 1.724% (29/1682) 2 entries
ENSG00000163161 lobular breast carcinoma missense_variant 1.299% (3/231) 1 entry
ENSG00000163161 bile duct adenocarcinoma missense_variant 1.039% (4/385) 2 entries
ENSG00000163161 gastric adenocarcinoma missense_variant 1.311% (11/839) 2 entries
ENSG00000163161 gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 1 entry
ENSG00000163161 ovarian serous adenocarcinoma missense_variant 0.2407% (2/831) 1 entry
ENSG00000163161 cecum adenocarcinoma missense_variant 1.111% (3/270) 1 entry
ENSG00000163161 lung adenocarcinoma missense_variant 0.5043% (13/2578) 3 entries
ENSG00000163161 prostate adenocarcinoma missense_variant 0.4188% (9/2149) 1 entry
ENSG00000163161 squamous cell lung carcinoma missense_variant 1.005% (10/995) 3 entries
ENSG00000163161 breast ductal adenocarcinoma missense_variant 0.743% (12/1615) 2 entries
ENSG00000163161 bladder transitional cell carcinoma missense_variant 1.121% (5/446) 1 entry
ENSG00000163161 thyroid carcinoma missense_variant 0.7559% (7/926) 1 entry
ENSG00000163161 rectal adenocarcinoma missense_variant 0.5415% (3/554) 1 entry
ENSG00000163161 brain glioblastoma missense_variant 0.165% (2/1212) 1 entry
ENSG00000163161 small intestinal adenocarcinoma missense_variant 9.524% (2/21) 1 entry
ENSG00000163161 Endometrial Endometrioid Adenocarcinoma missense_variant 1.703% (11/646) 1 entry
ENSG00000163161 melanoma missense_variant 4.138% (6/145) 2 entries
ENSG00000163161 pancreatic ductal adenocarcinoma missense_variant 1.724% (29/1682) 1 entry
ENSG00000163161 colon adenocarcinoma missense_variant 1.849% (24/1298) 5 entries
ENSG00000163161 skin melanoma missense_variant 1.034% (12/1161) 3 entries
ENSG00000163161 clear cell renal carcinoma missense_variant 0.2525% (4/1584) 2 entries
ENSG00000163161 esophageal squamous cell carcinoma missense_variant 1.022% (7/685) 3 entries
ENSG00000163161 anaplastic astrocytoma missense_variant 1.527% (2/131) 1 entry
ENSG00000163161 colon adenocarcinoma frameshift_variant 1.849% (24/1298) 1 entry
ENSG00000163161 Brain Stem Glioblastoma conservative_inframe_deletion 1.786% (1/56) 1 entry
ENSG00000163161 prostate carcinoma stop_gained 0.2066% (1/484) 1 entry
ENSG00000163161 testicular seminoma missense_variant 2.564% (2/78) 1 entry
ENSG00000163161 diffuse large B-cell lymphoma missense_variant 0.2695% (1/371) 1 entry
ENSG00000163161 lung adenocarcinoma frameshift_variant 0.5043% (13/2578) 1 entry
ENSG00000163161 HER2 Positive Breast Carcinoma missense_variant 1.829% (3/164) 1 entry
ENSG00000163161 chronic myelomonocytic leukemia frameshift_variant 2.105% (2/95) 1 entry
ENSG00000163161 chromophobe renal cell carcinoma missense_variant 0.6757% (1/148) 1 entry
ENSG00000163161 chronic myelomonocytic leukemia missense_variant 2.105% (2/95) 1 entry
ENSG00000163161 female breast carcinoma missense_variant 0.2558% (1/391) 1 entry
ENSG00000163161 Pleural Mesothelioma missense_variant 0.7353% (1/136) 1 entry
ENSG00000163161 testicular seminoma sequence_alteration 2.564% (2/78) 1 entry
ENSG00000163161 clear cell renal carcinoma sequence_alteration 0.2525% (4/1584) 1 entry
ENSG00000163161 anaplastic oligodendroglioma missense_variant 1.176% (1/85) 1 entry
ENSG00000163161 esophageal adenocarcinoma missense_variant 1.284% (7/545) 1 entry
ENSG00000163161 rectal adenocarcinoma stop_gained 0.5415% (3/554) 1 entry
ENSG00000163161 urothelial carcinoma missense_variant 1.163% (1/86) 1 entry
ENSG00000163161 small cell lung carcinoma missense_variant 0.2237% (1/447) 1 entry
ENSG00000163161 oral squamous cell carcinoma missense_variant 0.7576% (2/264) 1 entry
ENSG00000163161 oral squamous cell carcinoma frameshift_variant 0.7576% (2/264) 1 entry
ENSG00000163161 hepatocellular carcinoma frameshift_variant 0.4065% (4/984) 1 entry
ENSG00000163161 breast ductal adenocarcinoma stop_gained 0.743% (12/1615) 1 entry
ENSG00000163161 pancreatic neuroendocrine tumor missense_variant 0.8475% (2/236) 1 entry
ENSG00000163161 angiosarcoma sequence_alteration 2.128% (1/47) 1 entry
ENSG00000163161 central nervous system primitive neuroectodermal neoplasm missense_variant 0.2232% (1/448) 1 entry
ENSG00000163161 Mixed Lobular and Ductal Breast Carcinoma missense_variant 1.562% (1/64) 1 entry
ENSG00000163161 skin melanoma frameshift_variant 1.034% (12/1161) 1 entry
ENSG00000163161 gastric adenocarcinoma sequence_alteration 1.311% (11/839) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000163161 MESO 0.037 low
ENSG00000163161 SARC 0.00075 low
ENSG00000163161 LUSC 0.019 low
ENSG00000163161 HNSC 0.0078 high
ENSG00000163161 KIRP 0.00017 high
ENSG00000163161 KICH 0.011 high
ENSG00000163161 PCPG 0.039 low
ENSG00000163161 THYM 0.046 low
ENSG00000163161 COAD 0.011 high
ENSG00000163161 UCS 0.014 high
ENSG00000163161 DLBC 0.02 high
ENSG00000163161 BLCA 0.044 low
ENSG00000163161 GBM 0.049 low
ENSG00000163161 SKCM 0.0023 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000163161 DLBC Del 0.606686 0.117287 0.514915 0.125000
ENSG00000163161 PRAD Del 9.416229 0.145674 0.488471 0.158537