Ensembl ID ENSG00000162927 Gene ID 150962 Accession 26505
Gene Symbol PUS10 Alias DOBI;Hup10;CCDC139 Full Name pseudouridine synthase 10
Position 2 : 60940223 - 61018255 Length 78033 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Non-canonical_RBPs
Summary Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009]

ENSG00000162927 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000162927 PUS10 -0.7 2.97e-18 LIHC
ENSG00000162927 PUS10 -1.7 1.22e-24 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000162927 PUS10 tumor 19712588
ENSG00000162927 PUS10 breast cancer 23091737
ENSG00000162927 PUS10 tumor 26771136
ENSG00000162927 PUS10 tumor 28981101
ENSG00000162927 PUS10 cancer 31956354
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000162927 PUS10 CHOL 0.023 low
ENSG00000162927 PUS10 UVM 0.046 high
ENSG00000162927 PUS10 PAAD 0.039 high
ENSG00000162927 PUS10 UCEC 0.00015 high
ENSG00000162927 PUS10 ACC 0.0061 low
ENSG00000162927 PUS10 HNSC 0.025 low
ENSG00000162927 PUS10 READ 0.048 low
ENSG00000162927 PUS10 KIRP 0.012 high
ENSG00000162927 PUS10 LUAD 0.00011 low
ENSG00000162927 PUS10 THYM 0.025 low
ENSG00000162927 PUS10 BRCA 0.0056 high
ENSG00000162927 PUS10 COAD 0.015 high
ENSG00000162927 PUS10 ESCA 0.0012 high
ENSG00000162927 PUS10 OV 0.05 low
ENSG00000162927 PUS10 DLBC 0.018 high
ENSG00000162927 PUS10 BLCA 0.0012 low
ENSG00000162927 PUS10 CESC 0.025 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000162927 PUS10 LUSC Amp 15.309029 0.481128 0.715513 0.544910
ENSG00000162927 PUS10 DLBC Amp 12.818215 1.010342 1.446171 0.312500