Ensembl ID ENSG00000162688 Gene ID 178 Accession 321
Gene Symbol AGL Alias GDE Full Name amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
Position 1 : 99850361 - 99924023 Length 73663 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ENSG00000162688 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000162688 AGL -1.0 1.64e-37 KIRC
ENSG00000162688 AGL -1.6 1.37e-44 HNSC
ENSG00000162688 AGL -0.7 2.80e-11 COAD
ENSG00000162688 AGL -1.1 8.03e-11 READ
ENSG00000162688 AGL -0.5 4.65e-11 PRAD
ENSG00000162688 AGL -1.5 7.75e-28 LIHC
ENSG00000162688 AGL -2.6 6.54e-50 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000162688 AGL tumor 10799474
ENSG00000162688 AGL cancer 15953573
ENSG00000162688 AGL pancreatic cancer 1691065
ENSG00000162688 AGL tumor 24700805
ENSG00000162688 AGL cancer 25482527
ENSG00000162688 AGL pancreatic cancer 2563574
ENSG00000162688 AGL bladder cancer 26032551
ENSG00000162688 AGL tumor 26490312
ENSG00000162688 AGL Bladder cancer 26553625
ENSG00000162688 AGL tumour 26882899
ENSG00000162688 AGL tumor 26975021
ENSG00000162688 AGL bladder cancer 27595989
ENSG00000162688 AGL bladder cancer 28584628
ENSG00000162688 AGL GBM 29632728
ENSG00000162688 AGL non-small cell lung cancer 29682180
ENSG00000162688 AGL colon cancer 29928385
ENSG00000162688 AGL bladder cancer 30403777
ENSG00000162688 AGL tumor 30443561
ENSG00000162688 AGL tumor 30556699
ENSG00000162688 AGL pancreatic cancer 3362841
ENSG00000162688 AGL tumor 3596003
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000162688 AGL MESO 0.039 low
ENSG00000162688 AGL SARC 0.027 high
ENSG00000162688 AGL STAD 0.035 low
ENSG00000162688 AGL PAAD 0.007 high
ENSG00000162688 AGL UCEC 0.014 high
ENSG00000162688 AGL THCA 0.043 high
ENSG00000162688 AGL LUSC 0.0066 low
ENSG00000162688 AGL HNSC 0.041 low
ENSG00000162688 AGL READ 0.039 low
ENSG00000162688 AGL KIRP 0.022 low
ENSG00000162688 AGL COAD 0.0069 low
ENSG00000162688 AGL ESCA 0.036 high
ENSG00000162688 AGL DLBC 0.026 high
ENSG00000162688 AGL PRAD 0.029 high
ENSG00000162688 AGL BLCA 0.038 high
ENSG00000162688 AGL LAML 0.046 low
ENSG00000162688 AGL GBM 0.00084 low
ENSG00000162688 AGL CESC 0.014 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000162688 AGL LUSC Del 2.872268 0.092922 0.374923 0.419162
ENSG00000162688 AGL LUAD Del 8.701498 0.118126 0.348578 0.290698
ENSG00000162688 AGL CESC Del 0.956313 0.072299 0.432066 0.101695
ENSG00000162688 AGL COAD Del 4.648281 0.078018 0.421672 0.283814
ENSG00000162688 AGL SKCM Del 3.818926 0.109445 0.428762 0.239782
ENSG00000162688 AGL HNSC Del 3.054646 0.077777 0.362047 0.189655
ENSG00000162688 AGL PCPG Del 15.531859 0.246604 0.689993 0.746914
ENSG00000162688 AGL BRCA Del 7.256041 0.103453 0.395898 0.325000
ENSG00000162688 AGL STAD Del 0.938287 0.064075 0.358203 0.204082
ENSG00000162688 AGL MESO Del 9.438052 0.382039 0.575173 0.402299