Ensembl ID ENSG00000162676 Gene ID 2672 Accession 4237
Gene Symbol GFI1 Alias SCN2;GFI-1;GFI1A;ZNF163 Full Name growth factor independent 1 transcriptional repressor
Position 1 : 92473043 - 92486925 Length 13883 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

ENSG00000162676 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000162676 GFI1 2.46 9.45e-62 KIRC
ENSG00000162676 GFI1 1.88 4.46e-22 HNSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000162676 GFI1 tumor 11246463
ENSG00000162676 GFI1 lung cancer 15466176
ENSG00000162676 GFI1 prostate cancer 15947108
ENSG00000162676 GFI1 prostate cancer 17207994
ENSG00000162676 GFI1 cancer 20043076
ENSG00000162676 GFI1 acute myeloid leukemia (AML) 20075157
ENSG00000162676 GFI1 acute myeloid leukemia (AML) 22932805
ENSG00000162676 GFI1 AML 24708856
ENSG00000162676 GFI1 childhood cancer 25043047
ENSG00000162676 GFI1 laryngeal cancer 25719218
ENSG00000162676 GFI1 AML 27116251
ENSG00000162676 GFI1 tumour 28387757
ENSG00000162676 GFI1 tumor 28401061
ENSG00000162676 GFI1 AML 28894287
ENSG00000162676 GFI1 AML 29147018
ENSG00000162676 GFI1 AML 29156705
ENSG00000162676 GFI1 AML 29346763
ENSG00000162676 GFI1 tumors 29651020
ENSG00000162676 GFI1 colon cancer 30016783
ENSG00000162676 GFI1 AML 30250927
ENSG00000162676 GFI1 colorectal cancer 30606770
ENSG00000162676 GFI1 tumor 30659187
ENSG00000162676 GFI1 tumour 30858927
ENSG00000162676 GFI1 tumour 31225488
ENSG00000162676 GFI1 Gastric Cancer 31289136
ENSG00000162676 GFI1 tumour 31394667
ENSG00000162676 GFI1 acute myeloid leukemia (AML) 31508375
ENSG00000162676 GFI1 acute myeloid leukemia (AML) 31676828
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000162676 GFI1 UVM 0.00019 high
ENSG00000162676 GFI1 PAAD 0.014 high
ENSG00000162676 GFI1 UCEC 0.0031 low
ENSG00000162676 GFI1 HNSC 0.006 low
ENSG00000162676 GFI1 READ 0.0092 low
ENSG00000162676 GFI1 LUAD 0.0083 low
ENSG00000162676 GFI1 PCPG 0.0036 high
ENSG00000162676 GFI1 THYM 0.00044 low
ENSG00000162676 GFI1 BRCA 0.00088 low
ENSG00000162676 GFI1 COAD 0.00032 low
ENSG00000162676 GFI1 OV 0.0047 low
ENSG00000162676 GFI1 KIRC 0.012 high
ENSG00000162676 GFI1 BLCA 0.034 low
ENSG00000162676 GFI1 LAML 0.0055 low
ENSG00000162676 GFI1 GBM 0.021 high
ENSG00000162676 GFI1 SKCM 0.00018 low
ENSG00000162676 GFI1 CESC 0.018 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000162676 GFI1 LUAD Del 5.105144 0.093998 0.320772 0.277132
ENSG00000162676 GFI1 COAD Del 2.590352 0.061694 0.410442 0.281596
ENSG00000162676 GFI1 GBM Del 3.159404 0.078056 0.605643 0.072790
ENSG00000162676 GFI1 SKCM Del 5.637972 0.128915 0.445547 0.261580
ENSG00000162676 GFI1 HNSC Del 2.760511 0.075288 0.351663 0.187739
ENSG00000162676 GFI1 PCPG Del 15.032845 0.241257 0.683196 0.759259
ENSG00000162676 GFI1 BRCA Del 7.712466 0.105458 0.400222 0.329630
ENSG00000162676 GFI1 STAD Del 1.787920 0.075859 0.354385 0.224490
ENSG00000162676 GFI1 PRAD Del 0.958224 0.075477 0.458925 0.111789
ENSG00000162676 GFI1 MESO Del 9.745794 0.389505 0.573918 0.413793