Ensembl ID ENSG00000162521 Gene ID 5928 Accession 9887
Gene Symbol RBBP4 Alias NURF55;RBAP48;lin-53 Full Name RB binding protein 4, chromatin remodeling factor
Position 1 : 32651142 - 32686211 Length 35070 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

ENSG00000162521 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000162521 RBBP4 0.40 7.89e-18 BRCA
ENSG00000162521 RBBP4 0.46 4.33e-15 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000162521 RBBP4 AML 16029452
ENSG00000162521 RBBP4 oropharyngeal cancer 19221247
ENSG00000162521 RBBP4 cancer 21385632
ENSG00000162521 RBBP4 prostate cancer 24727455
ENSG00000162521 RBBP4 cancers 25210800
ENSG00000162521 RBBP4 tumor 26201719
ENSG00000162521 RBBP4 tumors 26972001
ENSG00000162521 RBBP4 cancer 28158555
ENSG00000162521 RBBP4 AML 29286103
ENSG00000162521 RBBP4 gastric cancer 29901205
ENSG00000162521 RBBP4 tumors 29914980
ENSG00000162521 RBBP4 tumor 30026490
ENSG00000162521 RBBP4 tumor 30462309
ENSG00000162521 RBBP4 tumor 30719075
ENSG00000162521 RBBP4 colon cancer 31501018
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000162521 RBBP4 MESO 0.036 low
ENSG00000162521 RBBP4 SARC 0.00056 high
ENSG00000162521 RBBP4 STAD 0.011 low
ENSG00000162521 RBBP4 UCEC 0.029 high
ENSG00000162521 RBBP4 THCA 0.041 low
ENSG00000162521 RBBP4 ACC 0.00048 high
ENSG00000162521 RBBP4 HNSC 0.0016 low
ENSG00000162521 RBBP4 KIRP 0.013 high
ENSG00000162521 RBBP4 KICH 0.00044 high
ENSG00000162521 RBBP4 LUAD 0.001 low
ENSG00000162521 RBBP4 THYM 0.0025 low
ENSG00000162521 RBBP4 BRCA 0.0016 low
ENSG00000162521 RBBP4 COAD 0.0033 high
ENSG00000162521 RBBP4 OV 0.015 low
ENSG00000162521 RBBP4 KIRC 0.0036 low
ENSG00000162521 RBBP4 PRAD 0.05 high
ENSG00000162521 RBBP4 BLCA 0.017 low
ENSG00000162521 RBBP4 GBM 0.0022 low
ENSG00000162521 RBBP4 SKCM 0.038 low
ENSG00000162521 RBBP4 CESC 0.0031 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000162521 RBBP4 CHOL Del 7.967105 0.613502 0.654079 0.527778
ENSG00000162521 RBBP4 KIRP Del 4.711721 0.062779 0.586110 0.163194
ENSG00000162521 RBBP4 READ Del 2.319410 0.110233 0.418574 0.381818
ENSG00000162521 RBBP4 COAD Del 6.351010 0.090021 0.422772 0.308204
ENSG00000162521 RBBP4 LIHC Del 10.398035 0.168835 0.533089 0.345946
ENSG00000162521 RBBP4 PCPG Del 1.893741 0.082870 0.673439 0.623457
ENSG00000162521 RBBP4 BRCA Del 4.840232 0.091825 0.389765 0.334259
ENSG00000162521 RBBP4 STAD Del 1.054290 0.065794 0.335067 0.206349
ENSG00000162521 RBBP4 UCEC Del 1.104019 0.053429 0.429505 0.085343
ENSG00000162521 RBBP4 KIRC Del 2.887256 0.037114 0.416872 0.166667
ENSG00000162521 RBBP4 UVM Del 1.063142 0.071726 0.771526 0.312500
ENSG00000162521 RBBP4 OV Amp 1.526955 0.358778 0.618236 0.369603
ENSG00000162521 RBBP4 OV Del 3.286365 0.223635 0.519404 0.260794