Ensembl ID ENSG00000162396 Gene ID 25973 Accession 30563
Gene Symbol PARS2 Alias DEE75;proRS;EIEE75;MT-PRORS Full Name prolyl-tRNA synthetase 2, mitochondrial
Position 1 : 54756898 - 54764523 Length 7626 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. [provided by RefSeq, Mar 2015]

ENSG00000162396 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000162396 PARS2 -0.5 1.34e-18 KIRC
ENSG00000162396 PARS2 0.50 1.23e-21 BRCA
ENSG00000162396 PARS2 0.97 1.09e-31 LUSC
ENSG00000162396 PARS2 0.92 3.04e-34 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000162396 PARS2 tumor 17018635
ENSG00000162396 PARS2 breast cancers 27612429
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000162396 PARS2 MESO 0.013 low
ENSG00000162396 PARS2 SARC 0.00079 high
ENSG00000162396 PARS2 STAD 0.022 low
ENSG00000162396 PARS2 UVM 0.043 low
ENSG00000162396 PARS2 UCEC 0.029 high
ENSG00000162396 PARS2 THCA 0.013 low
ENSG00000162396 PARS2 LGG 0.00028 high
ENSG00000162396 PARS2 HNSC 0.0014 low
ENSG00000162396 PARS2 READ 0.00019 low
ENSG00000162396 PARS2 KIRP 0.003 low
ENSG00000162396 PARS2 LUAD 0.029 low
ENSG00000162396 PARS2 PCPG 0.047 low
ENSG00000162396 PARS2 BRCA 0.023 low
ENSG00000162396 PARS2 COAD 0.0018 low
ENSG00000162396 PARS2 ESCA 0.015 low
ENSG00000162396 PARS2 PRAD 0.037 low
ENSG00000162396 PARS2 GBM 0.017 low
ENSG00000162396 PARS2 SKCM 1e-04 high
ENSG00000162396 PARS2 CESC 0.028 low
ENSG00000162396 PARS2 LIHC 0.00035 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000162396 PARS2 CHOL Del 1.144174 0.246604 0.630660 0.277778
ENSG00000162396 PARS2 COAD Del 0.676915 0.042010 0.394833 0.261641
ENSG00000162396 PARS2 PCPG Del 8.785362 0.177100 0.685440 0.722222
ENSG00000162396 PARS2 UVM Del 1.063142 0.074432 0.810346 0.287500