Ensembl ID ENSG00000162231 Gene ID 10482 Accession 8071
Gene Symbol NXF1 Alias TAP;MEX67 Full Name nuclear RNA export factor 1
Position 11 : 62792123 - 62806302 Length 14180 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

ENSG00000162231 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000162231 NXF1 tumour 15813965
ENSG00000162231 NXF1 cancer 26209800
ENSG00000162231 NXF1 cancer 27840927
ENSG00000162231 NXF1 Nervous System Cancer 29552131
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000162231 NXF1 MESO 0.02 low
ENSG00000162231 NXF1 PAAD 0.00034 low
ENSG00000162231 NXF1 UCEC 0.0026 low
ENSG00000162231 NXF1 THCA 0.0033 low
ENSG00000162231 NXF1 ACC 0.00089 high
ENSG00000162231 NXF1 LUSC 0.044 low
ENSG00000162231 NXF1 HNSC 0.014 low
ENSG00000162231 NXF1 READ 0.012 low
ENSG00000162231 NXF1 LUAD 0.0086 low
ENSG00000162231 NXF1 THYM 0.00039 low
ENSG00000162231 NXF1 BRCA 0.016 low
ENSG00000162231 NXF1 COAD 0.0076 high
ENSG00000162231 NXF1 ESCA 0.036 low
ENSG00000162231 NXF1 KIRC 0.025 high
ENSG00000162231 NXF1 PRAD 0.025 high
ENSG00000162231 NXF1 BLCA 0.018 low
ENSG00000162231 NXF1 LAML 0.049 high
ENSG00000162231 NXF1 SKCM 0.0066 low
ENSG00000162231 NXF1 CESC 0.003 low
ENSG00000162231 NXF1 LIHC 0.0094 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000162231 NXF1 HNSC Amp 1.032324 0.124804 0.389639 0.237548
ENSG00000162231 NXF1 TGCT Del 0.957361 0.062072 0.398030 0.760000
ENSG00000162231 NXF1 BRCA Del 1.710009 0.072377 0.432139 0.219444
ENSG00000162231 NXF1 UCEC Amp 0.736093 0.103772 0.519713 0.113173