Ensembl ID ENSG00000161634 Gene ID 117159 Accession 14669
Gene Symbol DCD Alias PIF;AIDD;DSEP;HCAP;DCD-1 Full Name dermcidin
Position 12 : 54644589 - 54648493 Length 3905 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

ENSG00000161634 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000161634 -5.0 4.01e-13 HNSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000161634 AML 11237060
ENSG00000161634 breast cancer 12953101
ENSG00000161634 tumours 15270886
ENSG00000161634 tumour 15377337
ENSG00000161634 tumour 16685272
ENSG00000161634 cancer 17448443
ENSG00000161634 prostate cancer 17626247
ENSG00000161634 cancer 18403914
ENSG00000161634 prostate cancer 18594538
ENSG00000161634 breast cancer 18949710
ENSG00000161634 tumour 19014393
ENSG00000161634 breast cancer 21179408
ENSG00000161634 tumor 21216960
ENSG00000161634 tumor 21397687
ENSG00000161634 prostate cancer 21643625
ENSG00000161634 cancer 22455996
ENSG00000161634 cancer 22477519
ENSG00000161634 tumor 23635446
ENSG00000161634 cancer 24002984
ENSG00000161634 breast cancer 24562771
ENSG00000161634 cancer 25271322
ENSG00000161634 breast cancer 25879571
ENSG00000161634 tumor 26118837
ENSG00000161634 tumor 27216146
ENSG00000161634 tumor 27326251
ENSG00000161634 breast cancer 27746730
ENSG00000161634 tumor 29641283
ENSG00000161634 gastric cancer 30226544
ENSG00000161634 Lung Cancer 31115649
ENSG00000161634 Prostate cancer 31300527
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000161634 UCEC 0.049 low
ENSG00000161634 HNSC 0.021 low
ENSG00000161634 BRCA 0.01 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000161634 ACC Amp 1.153993 0.301884 1.138995 0.766667