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| Ensembl ID | ENSG00000161011 | Gene ID | 8878 | Accession | 11280 |
| Gene Symbol | SQSTM1 | Alias | p60;p62;A170;DMRV;OSIL;PDB3;ZIP3;p62B;NADGP;FTDALS3 | Full Name | sequestosome 1 |
| Position | 5 : 179806408 - 179838078 | Length | 31671 bases | Strand | Plus strand |
| Status | Confidence | Main interacting RNAs | N.A. | RBP type | Non-canonical_RBPs |
| Summary | This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009] | ||||
ENSG00000161011 Expression In 33 Tumors
| Ensembl ID | Gene symbol | Log2 Foldchange | Pvaue | Cancer |
|---|---|---|---|---|
| ENSG00000161011 | 0.56 | 1.27e-13 | KIRC | |
| ENSG00000161011 | 1.05 | 4.73e-11 | LIHC |
| Ensembl ID | Gene symbol | Cancer types | Pubmed ID |
|---|---|---|---|
| ENSG00000161011 | breast cancers | 17395976 | |
| ENSG00000161011 | tumors | 19016598 | |
| ENSG00000161011 | breast cancer | 19444933 | |
| ENSG00000161011 | tumor | 19524509 | |
| ENSG00000161011 | cancer | 19713972 | |
| ENSG00000161011 | tumors | 19787053 | |
| ENSG00000161011 | cancer | 20103647 | |
| ENSG00000161011 | giant cell tumor | 20200946 | |
| ENSG00000161011 | tumor | 20520551 | |
| ENSG00000161011 | Colon cancer | 20930850 | |
| ENSG00000161011 | ovarian cancer | 21371883 | |
| ENSG00000161011 | colon cancer | 21461234 | |
| ENSG00000161011 | tumor | 21498118 | |
| ENSG00000161011 | tumors | 21746920 | |
| ENSG00000161011 | tumor | 21764854 | |
| ENSG00000161011 | cancer | 22074114 | |
| ENSG00000161011 | breast cancer | 22296116 | |
| ENSG00000161011 | lung cancer | 22412944 | |
| ENSG00000161011 | tumor | 22441015 | |
| ENSG00000161011 | breast cancer | 22457718 | |
| ENSG00000161011 | colon cancer | 22652752 | |
| ENSG00000161011 | cancer | 22860231 | |
| ENSG00000161011 | breast cancer | 23026799 | |
| ENSG00000161011 | prostate cancer | 23075929 | |
| ENSG00000161011 | breast cancer | 23221969 | |
| ENSG00000161011 | Tumor | 23965851 | |
| ENSG00000161011 | pancreatic cancer | 24048269 | |
| ENSG00000161011 | colorectal cancer | 24065390 | |
| ENSG00000161011 | tumor | 24069557 | |
| ENSG00000161011 | Prostate Cancer | 24073324 | |
| ENSG00000161011 | cancer | 24086340 | |
| ENSG00000161011 | metastatic prostate cancer | 24122957 | |
| ENSG00000161011 | cancer | 24291777 | |
| ENSG00000161011 | kidney cancer | 24332042 | |
| ENSG00000161011 | liver cancer | 24401568 | |
| ENSG00000161011 | tumor | 24492513 | |
| ENSG00000161011 | tumor | 24553345 | |
| ENSG00000161011 | breast cancer | 24599075 | |
| ENSG00000161011 | prostate cancer | 24655592 | |
| ENSG00000161011 | cancer | 24690104 | |
| ENSG00000161011 | tumor | 24731006 | |
| ENSG00000161011 | cancer | 24805111 | |
| ENSG00000161011 | bladder cancer | 24815071 | |
| ENSG00000161011 | tumor | 24888584 | |
| ENSG00000161011 | tumor | 24888590 | |
| ENSG00000161011 | cancer | 24922589 | |
| ENSG00000161011 | cancer | 24991204 | |
| ENSG00000161011 | cancer | 24991827 | |
| ENSG00000161011 | tumor | 25026213 | |
| ENSG00000161011 | acute myeloid leukemia (AML) | 25034783 | |
| ENSG00000161011 | breast cancers | 25088198 | |
| ENSG00000161011 | breast cancer | 25088800 | |
| ENSG00000161011 | prostate cancer | 25103771 | |
| ENSG00000161011 | renal tumors | 25126726 | |
| ENSG00000161011 | tumor | 25126736 | |
| ENSG00000161011 | tumors | 25159823 | |
| ENSG00000161011 | Mast Cell Tumors | 25161207 | |
| ENSG00000161011 | tumor | 25216025 | |
| ENSG00000161011 | ovarian cancer | 25269472 | |
| ENSG00000161011 | Cancer | 25277339 | |
| ENSG00000161011 | Tumor | 25323883 | |
| ENSG00000161011 | cancer | 25338734 | |
| ENSG00000161011 | colon cancer | 25375374 | |
| ENSG00000161011 | tumor | 25466963 | |
| ENSG00000161011 | tumor | 25496309 | |
| ENSG00000161011 | breast cancer | 25500539 | |
| ENSG00000161011 | HNSCC | 25714028 | |
| ENSG00000161011 | Epithelial Ovarian Cancer | 25859063 | |
| ENSG00000161011 | Prostate Cancer | 25925890 | |
| ENSG00000161011 | tumor | 26020424 | |
| ENSG00000161011 | breast cancer | 26034986 | |
| ENSG00000161011 | tumor | 26043024 | |
| ENSG00000161011 | cancers | 26162509 | |
| ENSG00000161011 | cancer | 26208877 | |
| ENSG00000161011 | cancer | 26301314 | |
| ENSG00000161011 | prostate cancer | 26423274 | |
| ENSG00000161011 | pancreatic cancer | 26458814 | |
| ENSG00000161011 | cancer | 26553068 | |
| ENSG00000161011 | tumors | 26565381 | |
| ENSG00000161011 | GBM | 26648842 | |
| ENSG00000161011 | tumors | 26743088 | |
| ENSG00000161011 | breast cancer | 26754771 | |
| ENSG00000161011 | GBM | 26775697 | |
| ENSG00000161011 | colon cancer | 26802026 | |
| ENSG00000161011 | tumor | 26876213 | |
| ENSG00000161011 | cancer | 26882440 | |
| ENSG00000161011 | gastric cancer | 26910278 | |
| ENSG00000161011 | cancers | 27038142 | |
| ENSG00000161011 | GBM | 27163161 | |
| ENSG00000161011 | non-small cell lung cancer | 27250032 | |
| ENSG00000161011 | esophageal cancer | 27310928 | |
| ENSG00000161011 | breast cancer | 27345399 | |
| ENSG00000161011 | tumor | 27367669 | |
| ENSG00000161011 | colorectal cancer | 27444698 | |
| ENSG00000161011 | lung cancer | 27467530 | |
| ENSG00000161011 | cancers | 27588471 | |
| ENSG00000161011 | cancers | 27683183 | |
| ENSG00000161011 | Tumors | 27708238 | |
| ENSG00000161011 | gastric cancer | 27725863 | |
| ENSG00000161011 | Liver Cancer | 27728806 | |
| ENSG00000161011 | cancer | 27839920 | |
| ENSG00000161011 | AML | 27864418 | |
| ENSG00000161011 | cancer | 27929542 | |
| ENSG00000161011 | AML | 28026112 | |
| ENSG00000161011 | tumors | 28052027 | |
| ENSG00000161011 | AML | 28118076 | |
| ENSG00000161011 | pancreatic cancer | 28139733 | |
| ENSG00000161011 | pancreatic cancer | 28176967 | |
| ENSG00000161011 | lung cancer | 28183697 | |
| ENSG00000161011 | tumor | 28348518 | |
| ENSG00000161011 | Thyroid Cancers | 28351223 | |
| ENSG00000161011 | cancer | 28358273 | |
| ENSG00000161011 | Tumor | 28405513 | |
| ENSG00000161011 | breast cancer | 28411887 | |
| ENSG00000161011 | cancers | 28450176 | |
| ENSG00000161011 | Ovarian Cancer | 28455291 | |
| ENSG00000161011 | ovarian cancer | 28498503 | |
| ENSG00000161011 | tumor | 28512249 | |
| ENSG00000161011 | breast cancer | 28628113 | |
| ENSG00000161011 | cancers | 28638475 | |
| ENSG00000161011 | breast cancer | 28696138 | |
| ENSG00000161011 | GBM | 28701921 | |
| ENSG00000161011 | tumor | 28749466 | |
| ENSG00000161011 | breast cancer | 28855742 | |
| ENSG00000161011 | tumor | 28915569 | |
| ENSG00000161011 | tumors | 28937603 | |
| ENSG00000161011 | breast cancer | 28968743 | |
| ENSG00000161011 | liver cancer | 28980855 | |
| ENSG00000161011 | ovarian cancer | 29022892 | |
| ENSG00000161011 | breast cancer | 29029506 | |
| ENSG00000161011 | GBM | 29033794 | |
| ENSG00000161011 | tumor | 29179443 | |
| ENSG00000161011 | non-small cell lung cancer | 29190983 | |
| ENSG00000161011 | tumor | 29328502 | |
| ENSG00000161011 | cancer | 29344310 | |
| ENSG00000161011 | tumor | 29592877 | |
| ENSG00000161011 | Tumor | 29634950 | |
| ENSG00000161011 | Cancer | 29656891 | |
| ENSG00000161011 | ovarian cancer | 29699801 | |
| ENSG00000161011 | tumors | 29707114 | |
| ENSG00000161011 | cancer | 29789637 | |
| ENSG00000161011 | cancer | 29928361 | |
| ENSG00000161011 | Cancer | 29930914 | |
| ENSG00000161011 | tumour | 29967346 | |
| ENSG00000161011 | gastric cancer | 29989092 | |
| ENSG00000161011 | prostate cancer | 29995557 | |
| ENSG00000161011 | lung cancer | 30018090 | |
| ENSG00000161011 | cancer | 30067838 | |
| ENSG00000161011 | ovarian cancer | 30081720 | |
| ENSG00000161011 | cancer | 30106434 | |
| ENSG00000161011 | non-small cell lung cancer | 30145925 | |
| ENSG00000161011 | tumor | 30198373 | |
| ENSG00000161011 | tumor | 30204247 | |
| ENSG00000161011 | non-small cell lung cancer | 30231667 | |
| ENSG00000161011 | TGCT | 30245976 | |
| ENSG00000161011 | tumour | 30247801 | |
| ENSG00000161011 | oral cancer | 30272335 | |
| ENSG00000161011 | tumors | 30289335 | |
| ENSG00000161011 | tumor | 30302016 | |
| ENSG00000161011 | prostate cancer | 30324661 | |
| ENSG00000161011 | colorectal cancer | 30339814 | |
| ENSG00000161011 | breast cancer | 30389135 | |
| ENSG00000161011 | cancer | 30397181 | |
| ENSG00000161011 | Malignant Tumor | 30410612 | |
| ENSG00000161011 | colon cancer | 30451832 | |
| ENSG00000161011 | cancer | 30477228 | |
| ENSG00000161011 | cancer | 30483817 | |
| ENSG00000161011 | cancer | 30499183 | |
| ENSG00000161011 | breast cancer | 30563263 | |
| ENSG00000161011 | AML | 30563411 | |
| ENSG00000161011 | tumors | 30603055 | |
| ENSG00000161011 | tumors | 30621754 | |
| ENSG00000161011 | liver tumors | 30642133 | |
| ENSG00000161011 | breast cancer | 30653426 | |
| ENSG00000161011 | cancer | 30654687 | |
| ENSG00000161011 | tumor | 30718520 | |
| ENSG00000161011 | cancer | 30736337 | |
| ENSG00000161011 | triple-negative breast cancer | 30773992 | |
| ENSG00000161011 | tumors | 30782064 | |
| ENSG00000161011 | inflammatory myofibroblastic tumor | 30790150 | |
| ENSG00000161011 | cancer | 30806145 | |
| ENSG00000161011 | cancer | 30875926 | |
| ENSG00000161011 | cancer | 30894055 | |
| ENSG00000161011 | tumor | 30896863 | |
| ENSG00000161011 | gastric cancer | 30925913 | |
| ENSG00000161011 | cancer | 30941888 | |
| ENSG00000161011 | tumor | 31016112 | |
| ENSG00000161011 | laryngeal cancer | 31050705 | |
| ENSG00000161011 | tumor | 31159487 | |
| ENSG00000161011 | Cancer | 31177911 | |
| ENSG00000161011 | cancer | 31182922 | |
| ENSG00000161011 | tumor | 31208298 | |
| ENSG00000161011 | NSCLC non-small cell lung cancer | 31217023 | |
| ENSG00000161011 | lung cancer | 31232177 | |
| ENSG00000161011 | tumor | 31242129 | |
| ENSG00000161011 | tumor | 31284710 | |
| ENSG00000161011 | tumours | 31332942 | |
| ENSG00000161011 | cancer | 31351198 | |
| ENSG00000161011 | tumor | 31401659 | |
| ENSG00000161011 | breast cancer | 31413316 | |
| ENSG00000161011 | tumor | 31462126 | |
| ENSG00000161011 | tumour | 31508470 | |
| ENSG00000161011 | cancer | 31510897 | |
| ENSG00000161011 | tumour | 31543384 | |
| ENSG00000161011 | cancer | 31608105 | |
| ENSG00000161011 | tumor | 31612776 | |
| ENSG00000161011 | tumors | 31637005 | |
| ENSG00000161011 | brain tumors | 31674265 | |
| ENSG00000161011 | tumor | 31679460 | |
| ENSG00000161011 | bladder cancer | 31685029 | |
| ENSG00000161011 | tumor | 31695024 | |
| ENSG00000161011 | Cancer | 31696776 | |
| ENSG00000161011 | cancer | 31754084 | |
| ENSG00000161011 | cancer | 31775562 | |
| ENSG00000161011 | pancreatic cancer | 31785531 | |
| ENSG00000161011 | gastric cancer | 31810936 | |
| ENSG00000161011 | kidney cancer | 31810986 | |
| ENSG00000161011 | tumour | 31880318 | |
| ENSG00000161011 | tumor | 31889127 | |
| ENSG00000161011 | lung cancer | 31931029 | |
| ENSG00000161011 | tumor | 31931659 | |
| ENSG00000161011 | Tumor | 31952347 | |
| ENSG00000161011 | cancer | 31983282 |
| Ensembl ID | Gene symbol | Disease/phenotype | Mutation type | Mutated / Total samples | Literature |
|---|
| Ensembl ID | Gene symbol | Cancer | P-value | Which worse | show |
|---|---|---|---|---|---|
| ENSG00000161011 | SARC | 0.00017 | low | ||
| ENSG00000161011 | UVM | 0.035 | high | ||
| ENSG00000161011 | THCA | 0.039 | low | ||
| ENSG00000161011 | ACC | 0.00053 | low | ||
| ENSG00000161011 | LUSC | 0.041 | high | ||
| ENSG00000161011 | READ | 0.0059 | low | ||
| ENSG00000161011 | LUAD | 0.047 | high | ||
| ENSG00000161011 | PCPG | 0.0028 | high | ||
| ENSG00000161011 | THYM | 0.0013 | high | ||
| ENSG00000161011 | OV | 0.015 | high | ||
| ENSG00000161011 | DLBC | 0.0046 | low | ||
| ENSG00000161011 | KIRC | 0.042 | low | ||
| ENSG00000161011 | TGCT | 0.0031 | high | ||
| ENSG00000161011 | BLCA | 0.042 | high | ||
| ENSG00000161011 | LAML | 0.01 | high | ||
| ENSG00000161011 | GBM | 0.012 | high | ||
| ENSG00000161011 | SKCM | 0.034 | low |
| Ensembl ID | Gene symbol | Cancer | CNV type | -log10(q-value) | G-score | average amplitude | frequency |
|---|---|---|---|---|---|---|---|
| ENSG00000161011 | LGG | Del | 4.251480 | 0.069855 | 0.418049 | 0.111111 | |
| ENSG00000161011 | KIRP | Amp | 0.969852 | 0.061208 | 0.634107 | 0.125000 | |
| ENSG00000161011 | ACC | Amp | 1.636341 | 0.386685 | 1.222109 | 0.677778 | |
| ENSG00000161011 | GBM | Del | 0.885415 | 0.054414 | 0.464196 | 0.097054 | |
| ENSG00000161011 | SKCM | Del | 1.310934 | 0.076405 | 0.479879 | 0.291553 | |
| ENSG00000161011 | HNSC | Del | 1.768856 | 0.066162 | 0.395338 | 0.373563 | |
| ENSG00000161011 | LIHC | Amp | 2.907330 | 0.165898 | 0.582556 | 0.354054 | |
| ENSG00000161011 | BLCA | Del | 1.669719 | 0.093405 | 0.399768 | 0.477941 | |
| ENSG00000161011 | KIRC | Amp | 59.407579 | 0.324820 | 0.550725 | 0.625000 |