Ensembl ID ENSG00000160957 Gene ID 9401 Accession 9949
Gene Symbol RECQL4 Alias RECQ4 Full Name RecQ like helicase 4
Position 8 : 144511288 - 144517845 Length 6558 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]

ENSG00000160957 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000160957 0.79 2.29e-11 KIRC
ENSG00000160957 1.24 2.67e-18 HNSC
ENSG00000160957 2.10 4.29e-22 BLCA
ENSG00000160957 2.80 1.04e-144 BRCA
ENSG00000160957 2.19 3.86e-46 COAD
ENSG00000160957 1.92 2.81e-25 KICH
ENSG00000160957 2.53 1.10e-14 READ
ENSG00000160957 3.67 9.23e-178 LUSC
ENSG00000160957 2.68 8.96e-52 LIHC
ENSG00000160957 2.11 1.93e-30 STAD
ENSG00000160957 3.02 3.72e-70 UCEC
ENSG00000160957 2.08 4.82e-18 ESCA
ENSG00000160957 2.05 3.00e-11 CHOL
ENSG00000160957 3.61 2.60e-19 CESC
ENSG00000160957 3.02 1.80e-92 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000160957 mesenchymal tumors 10552928
ENSG00000160957 cancer 12601557
ENSG00000160957 malignant tumor 15221963
ENSG00000160957 cancer 15317757
ENSG00000160957 tumor 15674334
ENSG00000160957 cancer 15703196
ENSG00000160957 tumors 15750208
ENSG00000160957 cancer 15889139
ENSG00000160957 cancer 16246145
ENSG00000160957 cancer 16271439
ENSG00000160957 cancer 16793395
ENSG00000160957 cancer 16949575
ENSG00000160957 cancer 17156731
ENSG00000160957 cancer 17364146
ENSG00000160957 cervical cancer 17504382
ENSG00000160957 cancer 17623900
ENSG00000160957 cancer 18003859
ENSG00000160957 tumor 18043285
ENSG00000160957 cancer 18074021
ENSG00000160957 tumour 18382428
ENSG00000160957 cancer 18414032
ENSG00000160957 cancer 18430459
ENSG00000160957 cancer 18449888
ENSG00000160957 cancer 18616953
ENSG00000160957 cancer 18693251
ENSG00000160957 cancer 18716613
ENSG00000160957 cancer 18719387
ENSG00000160957 tumors 19242607
ENSG00000160957 cancer 19572017
ENSG00000160957 cancer 19657341
ENSG00000160957 tumor 19759018
ENSG00000160957 cancer 20075015
ENSG00000160957 cancer 20081208
ENSG00000160957 cancer 20096650
ENSG00000160957 cancer 20113479
ENSG00000160957 cancer 20451470
ENSG00000160957 tumor 20465837
ENSG00000160957 tumor 20629083
ENSG00000160957 cancer 21752281
ENSG00000160957 cancer 21963973
ENSG00000160957 cancer 22296597
ENSG00000160957 cancer 22544709
ENSG00000160957 breast cancer 22737080
ENSG00000160957 tumour 23036272
ENSG00000160957 cancer 23238538
ENSG00000160957 tumor 23412794
ENSG00000160957 cancer 23627586
ENSG00000160957 cancer 23650516
ENSG00000160957 tumors 23874974
ENSG00000160957 cancer 24067899
ENSG00000160957 tumors 24416132
ENSG00000160957 cancer 24440721
ENSG00000160957 cancer 24518840
ENSG00000160957 cancer 24535824
ENSG00000160957 cancer 24746816
ENSG00000160957 tumors 24835790
ENSG00000160957 tumor 24924172
ENSG00000160957 cancer 24960165
ENSG00000160957 cancer 25460179
ENSG00000160957 cancer 25469175
ENSG00000160957 colorectal cancer 25538733
ENSG00000160957 cancer 25555679
ENSG00000160957 metastatic prostate cancer 25620975
ENSG00000160957 tumor 25859855
ENSG00000160957 cancer 25945795
ENSG00000160957 cancer 25984607
ENSG00000160957 cancer 26455304
ENSG00000160957 cancer 26632267
ENSG00000160957 breast cancers 26690729
ENSG00000160957 cancer 26877874
ENSG00000160957 cancer 26906415
ENSG00000160957 cancer 26962299
ENSG00000160957 Gastric Cancer 27013200
ENSG00000160957 cancer 27287744
ENSG00000160957 cancer 27320928
ENSG00000160957 cancer 27764811
ENSG00000160957 cancer 27859906
ENSG00000160957 cancer 27998982
ENSG00000160957 cancers 28090586
ENSG00000160957 breast cancers 28254786
ENSG00000160957 bone tumors 28421271
ENSG00000160957 cancer 28423363
ENSG00000160957 cancer 28653661
ENSG00000160957 tumor 29541191
ENSG00000160957 cancer 29642415
ENSG00000160957 cancer 29659569
ENSG00000160957 breast cancer 29673459
ENSG00000160957 cancer 29973652
ENSG00000160957 gastric cancer 30250613
ENSG00000160957 breast cancer 30584360
ENSG00000160957 cancer 30718377
ENSG00000160957 cancer 30947698
ENSG00000160957 cancer 30962000
ENSG00000160957 tumor 31248416
ENSG00000160957 cancer 31276497
ENSG00000160957 cancer 31303264
ENSG00000160957 cancer 31495919
ENSG00000160957 childhood cancer 31604778
ENSG00000160957 cancer 31772289
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000160957 colon adenocarcinoma frameshift_variant 2.576% (33/1281) 2 entries
ENSG00000160957 colon adenocarcinoma conservative_inframe_deletion 2.576% (33/1281) 1 entry
ENSG00000160957 colon adenocarcinoma stop_gained 2.576% (33/1281) 2 entries
ENSG00000160957 colorectal adenocarcinoma missense_variant 4.243% (53/1249) 3 entries
ENSG00000160957 colon adenocarcinoma sequence_alteration 2.576% (33/1281) 4 entries
ENSG00000160957 colorectal adenocarcinoma sequence_alteration 4.243% (53/1249) 2 entries
ENSG00000160957 colon adenocarcinoma missense_variant 2.576% (33/1281) 4 entries
ENSG00000160957 pancreatic ductal adenocarcinoma missense_variant 0.2973% (5/1682) 1 entry
ENSG00000160957 esophageal squamous cell carcinoma missense_variant 1.312% (9/686) 4 entries
ENSG00000160957 central nervous system primitive neuroectodermal neoplasm sequence_alteration 0.6696% (3/448) 1 entry
ENSG00000160957 skin melanoma sequence_alteration 1.381% (16/1159) 1 entry
ENSG00000160957 Endometrial Endometrioid Adenocarcinoma missense_variant 1.703% (11/646) 1 entry
ENSG00000160957 diffuse large B-cell lymphoma missense_variant 0.5405% (2/370) 1 entry
ENSG00000160957 small cell lung carcinoma frameshift_variant 1.121% (5/446) 1 entry
ENSG00000160957 esophageal adenocarcinoma sequence_alteration 0.9174% (5/545) 1 entry
ENSG00000160957 gastric adenocarcinoma missense_variant 2.026% (17/839) 2 entries
ENSG00000160957 esophageal adenocarcinoma missense_variant 0.9174% (5/545) 1 entry
ENSG00000160957 female breast carcinoma missense_variant 0.7673% (3/391) 2 entries
ENSG00000160957 clear cell renal carcinoma missense_variant 0.2527% (4/1583) 2 entries
ENSG00000160957 Mixed Lobular and Ductal Breast Carcinoma missense_variant 5.0% (3/60) 1 entry
ENSG00000160957 cecum adenocarcinoma sequence_alteration 3.717% (10/269) 1 entry
ENSG00000160957 bladder transitional cell carcinoma stop_gained 2.466% (11/446) 1 entry
ENSG00000160957 esophageal squamous cell carcinoma sequence_alteration 1.312% (9/686) 2 entries
ENSG00000160957 bile duct adenocarcinoma missense_variant 1.299% (5/385) 2 entries
ENSG00000160957 head and neck squamous cell carcinoma missense_variant 0.534% (4/749) 2 entries
ENSG00000160957 breast ductal adenocarcinoma sequence_alteration 0.8217% (13/1582) 1 entry
ENSG00000160957 gastric intestinal type adenocarcinoma sequence_alteration 5.882% (5/85) 1 entry
ENSG00000160957 lobular breast carcinoma sequence_alteration 1.299% (3/231) 1 entry
ENSG00000160957 small cell lung carcinoma sequence_alteration 1.121% (5/446) 2 entries
ENSG00000160957 melanoma missense_variant 5.517% (8/145) 3 entries
ENSG00000160957 melanoma sequence_alteration 5.517% (8/145) 2 entries
ENSG00000160957 skin melanoma missense_variant 1.381% (16/1159) 1 entry
ENSG00000160957 brain glioblastoma sequence_alteration 0.495% (6/1212) 1 entry
ENSG00000160957 non-small cell lung carcinoma sequence_alteration 2.857% (3/105) 1 entry
ENSG00000160957 prostate carcinoma missense_variant 1.446% (7/484) 2 entries
ENSG00000160957 non-small cell lung carcinoma missense_variant 2.857% (3/105) 1 entry
ENSG00000160957 breast carcinoma missense_variant 0.6106% (9/1474) 2 entries
ENSG00000160957 brain glioblastoma missense_variant 0.495% (6/1212) 1 entry
ENSG00000160957 lung adenocarcinoma missense_variant 1.125% (29/2578) 3 entries
ENSG00000160957 lung adenocarcinoma sequence_alteration 1.125% (29/2578) 2 entries
ENSG00000160957 urothelial carcinoma missense_variant 5.814% (5/86) 1 entry
ENSG00000160957 skin melanoma frameshift_variant 1.381% (16/1159) 1 entry
ENSG00000160957 prostate adenocarcinoma sequence_alteration 0.4188% (9/2149) 2 entries
ENSG00000160957 breast ductal adenocarcinoma missense_variant 0.8217% (13/1582) 1 entry
ENSG00000160957 gastric intestinal type adenocarcinoma missense_variant 5.882% (5/85) 1 entry
ENSG00000160957 ovarian serous adenocarcinoma missense_variant 0.2407% (2/831) 1 entry
ENSG00000160957 bladder transitional cell carcinoma sequence_alteration 2.466% (11/446) 1 entry
ENSG00000160957 squamous cell lung carcinoma missense_variant 1.206% (12/995) 2 entries
ENSG00000160957 Merkel cell skin cancer missense_variant 2.151% (2/93) 1 entry
ENSG00000160957 rectal adenocarcinoma missense_variant 0.3663% (2/546) 1 entry
ENSG00000160957 oral squamous cell carcinoma sequence_alteration 1.509% (4/265) 3 entries
ENSG00000160957 oral squamous cell carcinoma missense_variant 1.509% (4/265) 3 entries
ENSG00000160957 small cell lung carcinoma missense_variant 1.121% (5/446) 2 entries
ENSG00000160957 squamous cell lung carcinoma sequence_alteration 1.206% (12/995) 2 entries
ENSG00000160957 lobular breast carcinoma missense_variant 1.299% (3/231) 1 entry
ENSG00000160957 colorectal adenocarcinoma frameshift_variant 4.243% (53/1249) 1 entry
ENSG00000160957 bladder transitional cell carcinoma missense_variant 2.466% (11/446) 1 entry
ENSG00000160957 Endometrial Endometrioid Adenocarcinoma sequence_alteration 1.703% (11/646) 1 entry
ENSG00000160957 cecum adenocarcinoma missense_variant 3.717% (10/269) 1 entry
ENSG00000160957 prostate carcinoma sequence_alteration 1.446% (7/484) 2 entries
ENSG00000160957 Pleural Epithelioid Mesothelioma missense_variant 1.481% (2/135) 1 entry
ENSG00000160957 urothelial carcinoma sequence_alteration 5.814% (5/86) 1 entry
ENSG00000160957 prostate adenocarcinoma missense_variant 0.4188% (9/2149) 1 entry
ENSG00000160957 cecum adenocarcinoma stop_gained 3.717% (10/269) 1 entry
ENSG00000160957 laryngeal squamous cell carcinoma missense_variant 4.878% (2/41) 2 entries
ENSG00000160957 ovarian clear cell adenocarcinoma sequence_alteration 3.03% (1/33) 1 entry
ENSG00000160957 rectal adenocarcinoma sequence_alteration 0.3663% (2/546) 1 entry
ENSG00000160957 pancreatic ductal adenocarcinoma frameshift_variant 0.2973% (5/1682) 1 entry
ENSG00000160957 Mixed Lobular and Ductal Breast Carcinoma sequence_alteration 5.0% (3/60) 1 entry
ENSG00000160957 embryonal rhabdomyosarcoma sequence_alteration 1.163% (1/86) 1 entry
ENSG00000160957 prostate carcinoma stop_gained 1.446% (7/484) 1 entry
ENSG00000160957 oral squamous cell carcinoma frameshift_variant 1.509% (4/265) 1 entry
ENSG00000160957 gastric intestinal type adenocarcinoma frameshift_variant 5.882% (5/85) 1 entry
ENSG00000160957 osteosarcoma missense_variant 1.316% (2/152) 1 entry
ENSG00000160957 ovarian clear cell adenocarcinoma missense_variant 3.03% (1/33) 1 entry
ENSG00000160957 nasopharyngeal squamous cell carcinoma missense_variant 0.5556% (1/180) 1 entry
ENSG00000160957 Endometrial Endometrioid Adenocarcinoma frameshift_variant 1.703% (11/646) 1 entry
ENSG00000160957 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 1.01% (1/99) 1 entry
ENSG00000160957 Gastrointestinal stromal tumor sequence_alteration 0.6757% (1/148) 1 entry
ENSG00000160957 gastric adenocarcinoma stop_gained 2.026% (17/839) 1 entry
ENSG00000160957 ovarian serous adenocarcinoma sequence_alteration 0.2407% (2/831) 1 entry
ENSG00000160957 Merkel cell skin cancer sequence_alteration 2.151% (2/93) 1 entry
ENSG00000160957 Gallbladder Adenocarcinoma sequence_alteration 1.227% (2/163) 1 entry
ENSG00000160957 anaplastic oligodendroglioma sequence_alteration 1.176% (1/85) 1 entry
ENSG00000160957 Intimal Sarcoma sequence_alteration 12.5% (1/8) 1 entry
ENSG00000160957 Pancreatic Acinar Cell Carcinoma frameshift_variant 5.882% (2/34) 1 entry
ENSG00000160957 diffuse gastric adenocarcinoma sequence_alteration 2.439% (2/82) 1 entry
ENSG00000160957 osteosarcoma sequence_alteration 1.316% (2/152) 1 entry
ENSG00000160957 anaplastic oligodendroglioma missense_variant 1.176% (1/85) 1 entry
ENSG00000160957 papillary renal cell carcinoma amino_acid_insertion 0.2725% (1/367) 1 entry
ENSG00000160957 Gastrointestinal stromal tumor missense_variant 0.6757% (1/148) 1 entry
ENSG00000160957 embryonal rhabdomyosarcoma missense_variant 1.163% (1/86) 1 entry
ENSG00000160957 Pleural Epithelioid Mesothelioma sequence_alteration 1.481% (2/135) 1 entry
ENSG00000160957 diffuse gastric adenocarcinoma missense_variant 2.439% (2/82) 1 entry
ENSG00000160957 lung carcinoid tumor missense_variant 3.704% (1/27) 1 entry
ENSG00000160957 endometrial carcinoma missense_variant 4.167% (1/24) 1 entry
ENSG00000160957 lung adenocarcinoma frameshift_variant 1.125% (29/2578) 1 entry
ENSG00000160957 Duodenal Adenocarcinoma missense_variant 5.882% (1/17) 1 entry
ENSG00000160957 leiomyosarcoma sequence_alteration 1.0% (1/100) 1 entry
ENSG00000160957 leiomyosarcoma missense_variant 1.0% (1/100) 1 entry
ENSG00000160957 head and neck squamous cell carcinoma sequence_alteration 0.534% (4/749) 1 entry
ENSG00000160957 squamous cell lung carcinoma conservative_inframe_deletion 1.206% (12/995) 1 entry
ENSG00000160957 pancreatic ductal adenocarcinoma sequence_alteration 0.2973% (5/1682) 1 entry
ENSG00000160957 Intimal Sarcoma missense_variant 12.5% (1/8) 1 entry
ENSG00000160957 laryngeal squamous cell carcinoma sequence_alteration 4.878% (2/41) 1 entry
ENSG00000160957 breast ductal adenocarcinoma conservative_inframe_deletion 0.8217% (13/1582) 1 entry
ENSG00000160957 gastric adenocarcinoma frameshift_variant 2.026% (17/839) 1 entry
ENSG00000160957 basal cell carcinoma frameshift_variant 1.471% (1/68) 1 entry
ENSG00000160957 Pancreatic Acinar Cell Carcinoma sequence_alteration 5.882% (2/34) 1 entry
ENSG00000160957 cecum adenocarcinoma conservative_inframe_deletion 3.717% (10/269) 1 entry
ENSG00000160957 Gallbladder Adenocarcinoma missense_variant 1.227% (2/163) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000160957 SARC 0.00011 high
ENSG00000160957 STAD 0.012 low
ENSG00000160957 CHOL 0.022 high
ENSG00000160957 PAAD 0.022 high
ENSG00000160957 HNSC 0.03 low
ENSG00000160957 KIRP 0.00016 high
ENSG00000160957 KICH 0.022 high
ENSG00000160957 LUAD 7e-04 high
ENSG00000160957 PCPG 0.0048 high
ENSG00000160957 THYM 0.0016 low
ENSG00000160957 BRCA 0.0023 low
ENSG00000160957 UCS 0.02 high
ENSG00000160957 DLBC 0.003 low
ENSG00000160957 BLCA 0.045 low
ENSG00000160957 LAML 0.00018 high
ENSG00000160957 SKCM 0.0019 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency