Ensembl ID ENSG00000160917 Gene ID 10898 Accession 2327
Gene Symbol CPSF4 Alias NAR;NEB1;NEB-1;CPSF30 Full Name cleavage and polyadenylation specific factor 4
Position 7 : 99438922 - 99457373 Length 18452 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

ENSG00000160917 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000160917 CPSF4 0.36 1.74e-11 KIRC
ENSG00000160917 CPSF4 0.88 2.54e-22 COAD
ENSG00000160917 CPSF4 0.59 2.52e-11 KICH
ENSG00000160917 CPSF4 1.25 3.73e-46 LUSC
ENSG00000160917 CPSF4 0.84 4.23e-19 LIHC
ENSG00000160917 CPSF4 0.77 1.29e-18 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000160917 CPSF4 tumors 1555996
ENSG00000160917 CPSF4 cancer 17230597
ENSG00000160917 CPSF4 intestinal tumors 1904414
ENSG00000160917 CPSF4 intestinal tumors 2108948
ENSG00000160917 CPSF4 lung cancer 24358221
ENSG00000160917 CPSF4 lung cancer 24618080
ENSG00000160917 CPSF4 oral cancer 25256786
ENSG00000160917 CPSF4 tumor 25569656
ENSG00000160917 CPSF4 lung cancer 26061761
ENSG00000160917 CPSF4 colorectal cancer 26157550
ENSG00000160917 CPSF4 prostate cancer 26176602
ENSG00000160917 CPSF4 Rectal Cancer 26321890
ENSG00000160917 CPSF4 lung cancer 26628108
ENSG00000160917 CPSF4 colon cancer 26797111
ENSG00000160917 CPSF4 cancer 27041861
ENSG00000160917 CPSF4 lung cancer 27450326
ENSG00000160917 CPSF4 Colorectal Cancer 27997899
ENSG00000160917 CPSF4 tumor 28002324
ENSG00000160917 CPSF4 prostate cancer 28816267
ENSG00000160917 CPSF4 tumor 28962252
ENSG00000160917 CPSF4 thyroid cancer 29495002
ENSG00000160917 CPSF4 tumor 29534519
ENSG00000160917 CPSF4 tumor 29844447
ENSG00000160917 CPSF4 rectal cancer 30258994
ENSG00000160917 CPSF4 tumors 30542113
ENSG00000160917 CPSF4 tumor 30588523
ENSG00000160917 CPSF4 lung tumor 30970220
ENSG00000160917 CPSF4 Cancer 31010128
ENSG00000160917 CPSF4 tumors 3105460
ENSG00000160917 CPSF4 colon cancer 31301362
ENSG00000160917 CPSF4 tumour 31388645
ENSG00000160917 CPSF4 tumors 31417639
ENSG00000160917 CPSF4 Cancer 31466918
ENSG00000160917 CPSF4 bladder cancer 3928553
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000160917 CPSF4 MESO 0.047 high
ENSG00000160917 CPSF4 STAD 0.031 low
ENSG00000160917 CPSF4 CHOL 0.045 high
ENSG00000160917 CPSF4 PAAD 0.0087 low
ENSG00000160917 CPSF4 UCEC 0.013 low
ENSG00000160917 CPSF4 ACC 0.0014 high
ENSG00000160917 CPSF4 LUSC 0.018 low
ENSG00000160917 CPSF4 READ 0.012 low
ENSG00000160917 CPSF4 KIRP 0.018 high
ENSG00000160917 CPSF4 KICH 0.00066 high
ENSG00000160917 CPSF4 PCPG 0.0034 low
ENSG00000160917 CPSF4 COAD 0.013 high
ENSG00000160917 CPSF4 UCS 0.037 low
ENSG00000160917 CPSF4 ESCA 0.025 low
ENSG00000160917 CPSF4 DLBC 0.0026 low
ENSG00000160917 CPSF4 BLCA 0.0031 low
ENSG00000160917 CPSF4 LAML 0.039 low
ENSG00000160917 CPSF4 GBM 0.035 high
ENSG00000160917 CPSF4 SKCM 0.0022 high
ENSG00000160917 CPSF4 LIHC 0.00097 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000160917 CPSF4 LUSC Amp 2.071340 0.237474 0.554683 0.508982
ENSG00000160917 CPSF4 LUAD Amp 0.655235 0.115474 0.456181 0.430233
ENSG00000160917 CPSF4 LGG Amp 1.724128 0.058951 0.661646 0.319688
ENSG00000160917 CPSF4 PAAD Amp 2.779784 0.148340 0.496644 0.304348
ENSG00000160917 CPSF4 ESCA Amp 8.719068 0.620860 0.804679 0.570652
ENSG00000160917 CPSF4 HNSC Amp 7.792569 0.246802 0.608326 0.329502
ENSG00000160917 CPSF4 STAD Amp 10.762205 0.340334 0.637354 0.453515
ENSG00000160917 CPSF4 PRAD Amp 1.117396 0.051992 0.514307 0.205285