Ensembl ID ENSG00000160752 Gene ID 2224 Accession 3631
Gene Symbol FDPS Alias FPS;FPPS;POROK9 Full Name farnesyl diphosphate synthase
Position 1 : 155308748 - 155320666 Length 11919 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

ENSG00000160752 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000160752 0.73 4.67e-29 BRCA
ENSG00000160752 -0.6 1.09e-17 KICH
ENSG00000160752 -0.5 5.54e-11 KIRP
ENSG00000160752 0.80 1.96e-12 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000160752 tumours 16101154
ENSG00000160752 cancer 16698791
ENSG00000160752 tumors 17291279
ENSG00000160752 tumor 18852131
ENSG00000160752 adrenal cancer 19266097
ENSG00000160752 tumor 19494338
ENSG00000160752 tumors 19621390
ENSG00000160752 tumor 19819230
ENSG00000160752 tumor 20462513
ENSG00000160752 tumor 20711197
ENSG00000160752 prostate cancer 21196316
ENSG00000160752 prostate cancer 21335425
ENSG00000160752 lung cancer 22211244
ENSG00000160752 prostate cancer 22407328
ENSG00000160752 tumor 23032740
ENSG00000160752 tumour 24434328
ENSG00000160752 tumor 24554445
ENSG00000160752 prostate cancer 24713434
ENSG00000160752 tumour 25025965
ENSG00000160752 tumors 25426120
ENSG00000160752 tumors 26372812
ENSG00000160752 tumor 26578234
ENSG00000160752 cancer 26936487
ENSG00000160752 brain cancer 28419419
ENSG00000160752 gastric cancer 28666798
ENSG00000160752 tumor 28729550
ENSG00000160752 tumor 29075041
ENSG00000160752 cancer 29337059
ENSG00000160752 tumors 29937769
ENSG00000160752 cancer 30216637
ENSG00000160752 tumor 30333528
ENSG00000160752 tumor 30691162
ENSG00000160752 tumors 30914801
ENSG00000160752 prostate cancer 31366128
ENSG00000160752 cancer 31540279
ENSG00000160752 Pancreatic Cancer 31725297
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000160752 MESO 0.00032 high
ENSG00000160752 SARC 0.017 high
ENSG00000160752 THCA 0.025 low
ENSG00000160752 ACC 0.002 high
ENSG00000160752 HNSC 0.027 high
ENSG00000160752 KIRP 0.002 high
ENSG00000160752 KICH 0.004 high
ENSG00000160752 LUAD 0.0053 high
ENSG00000160752 PCPG 0.0081 low
ENSG00000160752 BRCA 0.024 low
ENSG00000160752 OV 0.00071 low
ENSG00000160752 KIRC 0.00079 low
ENSG00000160752 LAML 0.00036 high
ENSG00000160752 GBM 0.033 low
ENSG00000160752 SKCM 0.00055 high
ENSG00000160752 CESC 0.0015 high
ENSG00000160752 LIHC 0.00083 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000160752 CHOL Amp 1.295862 0.584280 1.005686 0.666667
ENSG00000160752 LUSC Amp 3.281654 0.268701 0.548830 0.526946
ENSG00000160752 LUAD Amp 19.192529 0.386446 0.601336 0.740310
ENSG00000160752 CESC Amp 2.753429 0.203975 0.620008 0.535593
ENSG00000160752 UCS Amp 4.555869 1.025630 1.020787 0.696429
ENSG00000160752 SARC Amp 2.363201 0.345536 0.674614 0.365759
ENSG00000160752 PAAD Amp 0.922175 0.089452 0.432459 0.331522
ENSG00000160752 SKCM Amp 3.324142 0.198681 0.685198 0.550409
ENSG00000160752 LIHC Amp 19.617589 0.422768 0.911383 0.759459
ENSG00000160752 PCPG Amp 0.826699 0.073359 0.649498 0.160494
ENSG00000160752 DLBC Amp 1.306895 0.247389 0.653875 0.250000
ENSG00000160752 BLCA Amp 8.310253 0.357807 0.583666 0.448529
ENSG00000160752 BRCA Amp 24.924833 0.386011 0.797792 0.738889
ENSG00000160752 STAD Amp 1.823234 0.165308 0.457208 0.360544
ENSG00000160752 PRAD Amp 3.108938 0.078539 0.658816 0.079268
ENSG00000160752 UCEC Amp 12.892220 0.278982 0.875140 0.469388
ENSG00000160752 OV Amp 12.858757 0.593529 0.744192 0.621762