Ensembl ID ENSG00000160294 Gene ID 8888 Accession 6946
Gene Symbol MCM3AP Alias GANP;SAC3;MAP80;PNRIID Full Name minichromosome maintenance complex component 3 associated protein
Position 21 : 46235133 - 46286297 Length 51165 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]

ENSG00000160294 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000160294 tumor 16431081
ENSG00000160294 cancer 22395445
ENSG00000160294 breast cancer 25219767
ENSG00000160294 breast cancer 26749495
ENSG00000160294 GBM 27229531
ENSG00000160294 malignant tumors 29375300
ENSG00000160294 tumor 30069164
ENSG00000160294 tumor 30782188
ENSG00000160294 breast cancer 30810967
ENSG00000160294 papillary thyroid cancer 31030335
ENSG00000160294 Cancer 31237446
ENSG00000160294 GBM 31478223
ENSG00000160294 lung cancer 31693222
ENSG00000160294 pancreatic cancer 31830901
ENSG00000160294 liver cancer 31836002
ENSG00000160294 tumor 31846894
ENSG00000160294 lymphoid tumor 31947626
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000160294 MESO 0.024 high
ENSG00000160294 SARC 0.016 high
ENSG00000160294 CHOL 0.015 low
ENSG00000160294 UVM 0.041 high
ENSG00000160294 THCA 0.00097 high
ENSG00000160294 ACC 0.014 high
ENSG00000160294 HNSC 0.0029 low
ENSG00000160294 READ 0.0084 low
ENSG00000160294 THYM 0.0089 low
ENSG00000160294 OV 0.0033 high
ENSG00000160294 DLBC 0.035 low
ENSG00000160294 KIRC 0.028 low
ENSG00000160294 LIHC 0.043 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000160294 LUSC Del 0.821670 0.067423 0.361331 0.558882
ENSG00000160294 LAML Amp 2.896252 0.091359 1.153172 0.062827
ENSG00000160294 READ Del 1.230479 0.087268 0.469261 0.418182
ENSG00000160294 SARC Del 2.780063 0.174825 0.484246 0.256809
ENSG00000160294 HNSC Del 2.284913 0.071140 0.360451 0.385057
ENSG00000160294 STAD Del 0.945424 0.064321 0.378156 0.442177
ENSG00000160294 OV Del 0.935527 0.180255 0.559030 0.395509