Ensembl ID ENSG00000159352 Gene ID 5710 Accession 9561
Gene Symbol PSMD4 Alias AF;ASF;S5A;AF-1;MCB1;Rpn10;pUB-R5 Full Name proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Position 1 : 151254709 - 151267479 Length 12771 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]

ENSG00000159352 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000159352 PSMD4 0.82 2.70e-40 BRCA
ENSG00000159352 PSMD4 0.82 1.54e-32 LUSC
ENSG00000159352 PSMD4 1.06 7.38e-23 LIHC
ENSG00000159352 PSMD4 0.93 2.01e-16 UCEC
ENSG00000159352 PSMD4 0.85 1.62e-24 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000159352 PSMD4 liver tumors 12079511
ENSG00000159352 PSMD4 tumors 17883861
ENSG00000159352 PSMD4 colon cancer 19734940
ENSG00000159352 PSMD4 tumors 27033953
ENSG00000159352 PSMD4 colorectal cancer 28117105
ENSG00000159352 PSMD4 breast cancer 28316110
ENSG00000159352 PSMD4 Cancer 29535384
ENSG00000159352 PSMD4 colon cancer 29899863
ENSG00000159352 PSMD4 tumor 30930224
ENSG00000159352 PSMD4 colorectal cancer 31013812
ENSG00000159352 PSMD4 esophageal cancer 31162820
ENSG00000159352 PSMD4 tumor 31434263
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000159352 PSMD4 MESO 0.00017 high
ENSG00000159352 PSMD4 UVM 0.0018 high
ENSG00000159352 PSMD4 PAAD 0.034 high
ENSG00000159352 PSMD4 THCA 0.016 low
ENSG00000159352 PSMD4 LGG 0.00019 low
ENSG00000159352 PSMD4 HNSC 0.02 high
ENSG00000159352 PSMD4 KICH 0.013 high
ENSG00000159352 PSMD4 LUAD 0.031 high
ENSG00000159352 PSMD4 PCPG 0.015 high
ENSG00000159352 PSMD4 BRCA 0.016 low
ENSG00000159352 PSMD4 COAD 0.007 high
ENSG00000159352 PSMD4 OV 0.025 low
ENSG00000159352 PSMD4 LAML 0.00018 high
ENSG00000159352 PSMD4 SKCM 0.0012 high
ENSG00000159352 PSMD4 LIHC 0.0036 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000159352 PSMD4 CHOL Amp 0.764067 0.433097 0.983467 0.611111
ENSG00000159352 PSMD4 LUSC Amp 4.535966 0.296580 0.574007 0.518962
ENSG00000159352 PSMD4 LUAD Amp 24.584899 0.444449 0.628701 0.732558
ENSG00000159352 PSMD4 CESC Amp 3.774570 0.233252 0.632976 0.532203
ENSG00000159352 PSMD4 READ Amp 1.357261 0.159213 0.625018 0.284848
ENSG00000159352 PSMD4 UCS Amp 3.066180 0.838087 0.875195 0.714286
ENSG00000159352 PSMD4 SARC Amp 5.831331 0.483935 0.765299 0.396887
ENSG00000159352 PSMD4 ESCA Amp 1.003756 0.279552 0.501283 0.494565
ENSG00000159352 PSMD4 SKCM Amp 4.021857 0.217886 0.685877 0.544959
ENSG00000159352 PSMD4 PCPG Amp 3.268801 0.113313 0.692676 0.172840
ENSG00000159352 PSMD4 TGCT Amp 0.627169 0.112646 0.445720 0.446667
ENSG00000159352 PSMD4 DLBC Amp 1.244370 0.242797 0.646019 0.250000
ENSG00000159352 PSMD4 BLCA Amp 20.711756 0.566232 0.710602 0.490196
ENSG00000159352 PSMD4 BRCA Amp 28.799142 0.413242 0.817409 0.719444
ENSG00000159352 PSMD4 STAD Amp 4.465623 0.226504 0.511931 0.360544
ENSG00000159352 PSMD4 PRAD Amp 2.725469 0.073164 0.610760 0.081301
ENSG00000159352 PSMD4 UCEC Amp 21.318593 0.365911 0.957496 0.456401
ENSG00000159352 PSMD4 OV Amp 22.370022 0.727287 0.810087 0.632124