Ensembl ID ENSG00000158290 Gene ID 8450 Accession 2555
Gene Symbol CUL4B Alias SFM2;MRXSC;CUL-4B;MRXHF2;MRXS15 Full Name cullin 4B
Position X : 120505920 - 120603930 Length 98011 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000158290 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000158290 0.46 1.15e-12 LUSC
ENSG00000158290 0.39 1.74e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000158290 tumor 20075607
ENSG00000158290 tumor 22649780
ENSG00000158290 cancer 23227454
ENSG00000158290 cancers 23238014
ENSG00000158290 colon cancer 23649548
ENSG00000158290 cancer 23802180
ENSG00000158290 tumor 24292684
ENSG00000158290 breast cancer 24884718
ENSG00000158290 tumour 25430888
ENSG00000158290 cancer 25664533
ENSG00000158290 brain tumors 25855927
ENSG00000158290 cancer 25883150
ENSG00000158290 liver tumors 25945838
ENSG00000158290 Tumor 26450912
ENSG00000158290 cancer 26460955
ENSG00000158290 colorectal cancer 26617747
ENSG00000158290 Non-Small Cell Lung Cancer 27656838
ENSG00000158290 Lung Cancer 27974468
ENSG00000158290 tumor 28164432
ENSG00000158290 cancers 28446751
ENSG00000158290 tumor 28465351
ENSG00000158290 cancers 28630798
ENSG00000158290 pancreatic cancer 28685847
ENSG00000158290 bladder cancer 29100384
ENSG00000158290 gastric cancer 29106389
ENSG00000158290 pancreatic cancer 29274277
ENSG00000158290 tumor 29377600
ENSG00000158290 gastric cancer 29393470
ENSG00000158290 tumor 29499938
ENSG00000158290 tumor 29581734
ENSG00000158290 cancer 29738775
ENSG00000158290 breast cancer 29846670
ENSG00000158290 colorectal cancer 29863249
ENSG00000158290 colorectal cancer 30178820
ENSG00000158290 tumor 30229816
ENSG00000158290 gastric cancer 30483755
ENSG00000158290 prostate cancer 30609075
ENSG00000158290 cancers 30612524
ENSG00000158290 tumor 30872583
ENSG00000158290 tumors 30883036
ENSG00000158290 tumour 30945288
ENSG00000158290 cancer 31111526
ENSG00000158290 cancer 31235785
ENSG00000158290 breast cancer 31374029
ENSG00000158290 non-small cell lung cancer 31407591
ENSG00000158290 lung cancer 31448526
ENSG00000158290 tumor 31598391
ENSG00000158290 cancer 31690264
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000158290 STAD 0.044 high
ENSG00000158290 UCEC 0.0039 high
ENSG00000158290 ACC 0.04 low
ENSG00000158290 LGG 0.0076 high
ENSG00000158290 LUSC 0.045 low
ENSG00000158290 KICH 0.00029 high
ENSG00000158290 LUAD 0.0015 high
ENSG00000158290 BRCA 0.036 high
ENSG00000158290 DLBC 0.015 high
ENSG00000158290 KIRC 0.00059 low
ENSG00000158290 PRAD 0.035 high
ENSG00000158290 LAML 0.033 low
ENSG00000158290 GBM 0.032 low
ENSG00000158290 SKCM 0.035 low
ENSG00000158290 CESC 0.024 low
ENSG00000158290 LIHC 0.0038 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency