Ensembl ID ENSG00000155966 Gene ID 2334 Accession 3776
Gene Symbol AFF2 Alias FMR2;MRX2;OX19;FMR2P;FRAXE;XLID109 Full Name ALF transcription elongation factor 2
Position X : 148500617 - 149000663 Length 500047 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a putative transcriptional activator that is a member of the AF4FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]

ENSG00000155966 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000155966 AFF2 1.18 3.90e-16 KIRC
ENSG00000155966 AFF2 -1.6 1.70e-18 PRAD
ENSG00000155966 AFF2 2.23 3.71e-16 KIRP
ENSG00000155966 AFF2 3.55 2.16e-17 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000155966 AFF2 GBM 25351872
ENSG00000155966 AFF2 tumor 31011208
ENSG00000155966 AFF2 tumor 3742601
ENSG00000155966 AFF2 tumor 8225852
ENSG00000155966 AFF2 cancer 9299237
ENSG00000155966 AFF2 tumours 9893033
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000155966 AFF2 STAD 0.00033 high
ENSG00000155966 AFF2 UVM 0.004 high
ENSG00000155966 AFF2 PAAD 0.012 low
ENSG00000155966 AFF2 UCEC 0.012 low
ENSG00000155966 AFF2 LUSC 0.037 low
ENSG00000155966 AFF2 READ 0.0052 low
ENSG00000155966 AFF2 KIRP 0.017 high
ENSG00000155966 AFF2 LUAD 0.01 low
ENSG00000155966 AFF2 COAD 0.044 low
ENSG00000155966 AFF2 DLBC 0.049 low
ENSG00000155966 AFF2 KIRC 9e-04 low
ENSG00000155966 AFF2 TGCT 0.028 low
ENSG00000155966 AFF2 BLCA 0.024 high
ENSG00000155966 AFF2 LAML 0.00042 low
ENSG00000155966 AFF2 CESC 0.027 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency