Ensembl ID ENSG00000155966 Gene ID 2334 Accession 3776
Gene Symbol AFF2 Alias FMR2;MRX2;OX19;FMR2P;FRAXE;XLID109 Full Name ALF transcription elongation factor 2
Position X : 148500617 - 149000663 Length 500047 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a putative transcriptional activator that is a member of the AF4FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]

ENSG00000155966 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000155966 1.18 3.90e-16 KIRC
ENSG00000155966 -1.6 1.70e-18 PRAD
ENSG00000155966 2.23 3.71e-16 KIRP
ENSG00000155966 3.55 2.16e-17 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000155966 GBM 25351872
ENSG00000155966 tumor 31011208
ENSG00000155966 tumor 3742601
ENSG00000155966 tumor 8225852
ENSG00000155966 cancer 9299237
ENSG00000155966 tumours 9893033
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000155966 STAD 0.00033 high
ENSG00000155966 UVM 0.004 high
ENSG00000155966 PAAD 0.012 low
ENSG00000155966 UCEC 0.012 low
ENSG00000155966 LUSC 0.037 low
ENSG00000155966 READ 0.0052 low
ENSG00000155966 KIRP 0.017 high
ENSG00000155966 LUAD 0.01 low
ENSG00000155966 COAD 0.044 low
ENSG00000155966 DLBC 0.049 low
ENSG00000155966 KIRC 9e-04 low
ENSG00000155966 TGCT 0.028 low
ENSG00000155966 BLCA 0.024 high
ENSG00000155966 LAML 0.00042 low
ENSG00000155966 CESC 0.027 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency