Ensembl ID ENSG00000155660 Gene ID 9601 Accession 30167
Gene Symbol PDIA4 Alias ERP70;ERP72;ERp-72 Full Name protein disulfide isomerase family A member 4
Position 7 : 149003062 - 149028662 Length 25601 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]

ENSG00000155660 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000155660 PDIA4 0.75 4.90e-16 KIRC
ENSG00000155660 PDIA4 0.95 1.34e-27 HNSC
ENSG00000155660 PDIA4 1.35 4.42e-19 BLCA
ENSG00000155660 PDIA4 1.18 4.90e-72 BRCA
ENSG00000155660 PDIA4 0.71 4.09e-16 COAD
ENSG00000155660 PDIA4 1.53 3.19e-54 LUSC
ENSG00000155660 PDIA4 0.55 6.71e-11 PRAD
ENSG00000155660 PDIA4 2.45 1.18e-16 GBM
ENSG00000155660 PDIA4 1.51 1.05e-43 UCEC
ENSG00000155660 PDIA4 1.76 4.66e-66 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000155660 PDIA4 tumors 10352256
ENSG00000155660 PDIA4 tumors 12359958
ENSG00000155660 PDIA4 cancers 22028587
ENSG00000155660 PDIA4 tumor 24039668
ENSG00000155660 PDIA4 cancer 24464223
ENSG00000155660 PDIA4 tumor 26351857
ENSG00000155660 PDIA4 cancer 27246909
ENSG00000155660 PDIA4 cancer 27799870
ENSG00000155660 PDIA4 tumor 28534513
ENSG00000155660 PDIA4 ovarian cancer 29262583
ENSG00000155660 PDIA4 cancer 31794946
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000155660 PDIA4 MESO 0.0076 high
ENSG00000155660 PDIA4 SARC 0.0048 high
ENSG00000155660 PDIA4 UVM 0.00025 high
ENSG00000155660 PDIA4 PAAD 0.0043 high
ENSG00000155660 PDIA4 UCEC 0.016 low
ENSG00000155660 PDIA4 LUSC 0.034 high
ENSG00000155660 PDIA4 HNSC 0.02 high
ENSG00000155660 PDIA4 READ 0.0076 high
ENSG00000155660 PDIA4 KICH 0.01 high
ENSG00000155660 PDIA4 LUAD 0.0051 high
ENSG00000155660 PDIA4 ESCA 0.012 low
ENSG00000155660 PDIA4 OV 0.0068 low
ENSG00000155660 PDIA4 LAML 0.002 low
ENSG00000155660 PDIA4 GBM 0.00029 high
ENSG00000155660 PDIA4 SKCM 0.0099 low
ENSG00000155660 PDIA4 CESC 0.023 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000155660 PDIA4 LUSC Del 1.605308 0.078227 0.346242 0.181637
ENSG00000155660 PDIA4 LAML Del 2.834280 0.058384 0.713867 0.130890
ENSG00000155660 PDIA4 LGG Amp 5.559584 0.106314 0.673903 0.339181
ENSG00000155660 PDIA4 CESC Del 2.046526 0.091750 0.494627 0.203390
ENSG00000155660 PDIA4 KIRP Amp 0.728981 0.053975 0.920546 0.604167
ENSG00000155660 PDIA4 SARC Del 2.025811 0.157974 0.534921 0.225681
ENSG00000155660 PDIA4 PAAD Del 0.963676 0.051191 0.379816 0.081522
ENSG00000155660 PDIA4 ESCA Del 8.498457 0.258895 0.433533 0.358696
ENSG00000155660 PDIA4 SKCM Amp 5.013622 0.242680 0.725233 0.591281
ENSG00000155660 PDIA4 HNSC Del 18.105905 0.162812 0.420511 0.233716
ENSG00000155660 PDIA4 DLBC Del 0.707921 0.126309 0.468069 0.145833
ENSG00000155660 PDIA4 BRCA Del 0.977442 0.066062 0.421202 0.166667
ENSG00000155660 PDIA4 STAD Del 3.917165 0.098691 0.356825 0.190476
ENSG00000155660 PDIA4 UCEC Del 1.237622 0.055036 0.471727 0.109462
ENSG00000155660 PDIA4 OV Amp 11.022044 0.564156 0.759043 0.530225