Ensembl ID ENSG00000154743 Gene ID 80746 Accession 28422
Gene Symbol TSEN2 Alias SEN2;PCH2B;SEN2L Full Name tRNA splicing endonuclease subunit 2
Position 3 : 12484421 - 12541549 Length 57129 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

ENSG00000154743 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000154743 TSEN2 1.11 1.01e-23 COAD
ENSG00000154743 TSEN2 1.36 1.51e-11 READ
ENSG00000154743 TSEN2 0.61 6.26e-11 KIRP
ENSG00000154743 TSEN2 0.58 1.94e-12 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000154743 TSEN2 SARC 0.011 high
ENSG00000154743 TSEN2 UVM 4e-04 low
ENSG00000154743 TSEN2 UCEC 0.028 high
ENSG00000154743 TSEN2 LGG 0.0024 low
ENSG00000154743 TSEN2 READ 0.00046 low
ENSG00000154743 TSEN2 KICH 0.0026 high
ENSG00000154743 TSEN2 BRCA 0.042 low
ENSG00000154743 TSEN2 ESCA 0.043 high
ENSG00000154743 TSEN2 KIRC 0.00013 high
ENSG00000154743 TSEN2 TGCT 0.0012 high
ENSG00000154743 TSEN2 BLCA 0.0013 low
ENSG00000154743 TSEN2 LAML 0.014 low
ENSG00000154743 TSEN2 LIHC 0.00011 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000154743 TSEN2 BLCA Amp 28.225758 0.674710 0.845580 0.460784
ENSG00000154743 TSEN2 KIRC Del 52.066539 0.184748 0.517101 0.875000
ENSG00000154743 TSEN2 OV Del 2.569222 0.212416 0.489622 0.355786