Ensembl ID ENSG00000153944 Gene ID 124540 Accession 18585
Gene Symbol MSI2 Alias MSI2H Full Name musashi RNA binding protein 2
Position 17 : 57255851 - 57684689 Length 428839 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]

ENSG00000153944 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000153944 MSI2 -1.0 1.44e-26 KIRC
ENSG00000153944 MSI2 0.96 1.06e-30 BRCA
ENSG00000153944 MSI2 1.13 5.18e-29 COAD
ENSG00000153944 MSI2 1.44 2.01e-26 KICH
ENSG00000153944 MSI2 1.42 6.16e-34 LUSC
ENSG00000153944 MSI2 0.77 3.34e-12 STAD
ENSG00000153944 MSI2 1.64 3.73e-17 CHOL
ENSG00000153944 MSI2 1.18 2.57e-40 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000153944 MSI2 tumors 17615543
ENSG00000153944 MSI2 bladder cancer 20477901
ENSG00000153944 MSI2 acute myeloid leukemia (AML) 20616797
ENSG00000153944 MSI2 acute myeloid leukemia (AML) 22784712
ENSG00000153944 MSI2 brain cancer 23667531
ENSG00000153944 MSI2 cancer 23696360
ENSG00000153944 MSI2 tumor 24002004
ENSG00000153944 MSI2 tumour 24305552
ENSG00000153944 MSI2 tumors 24671879
ENSG00000153944 MSI2 acute myeloid leukemia (AML) 25090928
ENSG00000153944 MSI2 acute myeloid leukemia (AML) 25338564
ENSG00000153944 MSI2 acute myeloid leukemia (AML) 25449073
ENSG00000153944 MSI2 cancer 25733820
ENSG00000153944 MSI2 tumor 25774828
ENSG00000153944 MSI2 tumor 26045988
ENSG00000153944 MSI2 tumours 26169690
ENSG00000153944 MSI2 AML 26212080
ENSG00000153944 MSI2 acute myeloid leukemia (AML) 26308531
ENSG00000153944 MSI2 intestinal cancers 26673327
ENSG00000153944 MSI2 colorectal cancer 26775684
ENSG00000153944 MSI2 pancreatic cancer 27092875
ENSG00000153944 MSI2 tumor 27274057
ENSG00000153944 MSI2 pancreatic cancer 27281208
ENSG00000153944 MSI2 bladder cancer 27322953
ENSG00000153944 MSI2 Pancreatic Cancer 27449499
ENSG00000153944 MSI2 breast cancer 27593929
ENSG00000153944 MSI2 ovarian cancer 27600258
ENSG00000153944 MSI2 liver cancer 27721018
ENSG00000153944 MSI2 breast cancer 27941885
ENSG00000153944 MSI2 AML 28107692
ENSG00000153944 MSI2 cancer 28143872
ENSG00000153944 MSI2 pancreatic cancer 28223335
ENSG00000153944 MSI2 cancer 28436985
ENSG00000153944 MSI2 cancer 28514443
ENSG00000153944 MSI2 cancers 28912529
ENSG00000153944 MSI2 colorectal cancers 29064439
ENSG00000153944 MSI2 cervical cancer 29073938
ENSG00000153944 MSI2 tumour 29093438
ENSG00000153944 MSI2 cancers 29290973
ENSG00000153944 MSI2 cervical cancer 29556294
ENSG00000153944 MSI2 tumor 30034243
ENSG00000153944 MSI2 colon cancer 30097032
ENSG00000153944 MSI2 cancer 30126842
ENSG00000153944 MSI2 cancer 30367664
ENSG00000153944 MSI2 bladder cancer 30419948
ENSG00000153944 MSI2 colon cancer 30604502
ENSG00000153944 MSI2 cancer 30719075
ENSG00000153944 MSI2 tumor 30854035
ENSG00000153944 MSI2 cancer 30976575
ENSG00000153944 MSI2 malignant peripheral nerve sheath tumour 31053152
ENSG00000153944 MSI2 tumor 31066120
ENSG00000153944 MSI2 cancers 31217428
ENSG00000153944 MSI2 tumor 31250154
ENSG00000153944 MSI2 prostate cancer 31833612
ENSG00000153944 MSI2 tumors 31870844
ENSG00000153944 MSI2 cancers 31878037
ENSG00000153944 MSI2 liver cancer 31888685
ENSG00000153944 MSI2 pancreatic cancer 31952541
ENSG00000153944 MSI2 ovarian cancer 31957818
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000153944 MSI2 breast ductal adenocarcinoma sequence_alteration 27.23% (159/584) 1 entry
ENSG00000153944 MSI2 pancreatic carcinoma missense_variant 14.04% (16/114) 1 entry
ENSG00000153944 MSI2 skin melanoma missense_variant 0.7239% (7/967) 1 entry
ENSG00000153944 MSI2 cecum adenocarcinoma sequence_alteration 12.0% (15/125) 1 entry
ENSG00000153944 MSI2 skin melanoma sequence_alteration 0.7239% (7/967) 2 entries
ENSG00000153944 MSI2 oral squamous cell carcinoma sequence_alteration 2.927% (6/205) 2 entries
ENSG00000153944 MSI2 gastric adenocarcinoma missense_variant 0.5376% (3/558) 1 entry
ENSG00000153944 MSI2 esophageal squamous cell carcinoma sequence_alteration 0.4444% (3/675) 1 entry
ENSG00000153944 MSI2 melanoma missense_variant 3.96% (4/101) 1 entry
ENSG00000153944 MSI2 prostate carcinoma sequence_alteration 3.719% (18/484) 1 entry
ENSG00000153944 MSI2 female breast carcinoma sequence_alteration 0.5115% (2/391) 1 entry
ENSG00000153944 MSI2 colorectal adenocarcinoma sequence_alteration 2.9% (33/1138) 1 entry
ENSG00000153944 MSI2 cecum adenocarcinoma missense_variant 12.0% (15/125) 1 entry
ENSG00000153944 MSI2 colon adenocarcinoma sequence_alteration 6.787% (49/722) 2 entries
ENSG00000153944 MSI2 chronic lymphocytic leukemia sequence_alteration 3.829% (34/888) 2 entries
ENSG00000153944 MSI2 central nervous system primitive neuroectodermal neoplasm sequence_alteration 3.153% (14/444) 1 entry
ENSG00000153944 MSI2 colon adenocarcinoma missense_variant 6.787% (49/722) 2 entries
ENSG00000153944 MSI2 clear cell renal carcinoma sequence_alteration 0.508% (7/1378) 1 entry
ENSG00000153944 MSI2 lung adenocarcinoma missense_variant 0.1639% (2/1220) 2 entries
ENSG00000153944 MSI2 esophageal squamous cell carcinoma missense_variant 0.4444% (3/675) 1 entry
ENSG00000153944 MSI2 colorectal adenocarcinoma missense_variant 2.9% (33/1138) 2 entries
ENSG00000153944 MSI2 brain glioblastoma sequence_alteration 0.432% (4/926) 2 entries
ENSG00000153944 MSI2 lung adenocarcinoma sequence_alteration 0.1639% (2/1220) 1 entry
ENSG00000153944 MSI2 ovarian serous adenocarcinoma missense_variant 0.1486% (1/673) 1 entry
ENSG00000153944 MSI2 nasopharyngeal squamous cell carcinoma missense_variant 0.5988% (1/167) 1 entry
ENSG00000153944 MSI2 colorectal adenocarcinoma stop_lost 2.9% (33/1138) 1 entry
ENSG00000153944 MSI2 chondroblastoma sequence_alteration 16.67% (1/6) 1 entry
ENSG00000153944 MSI2 basal cell carcinoma sequence_alteration 1.724% (1/58) 1 entry
ENSG00000153944 MSI2 Merkel cell skin cancer missense_variant 3.333% (1/30) 1 entry
ENSG00000153944 MSI2 diffuse gastric adenocarcinoma sequence_alteration 1.266% (1/79) 1 entry
ENSG00000153944 MSI2 T-cell acute lymphoblastic leukemia missense_variant 0.2632% (1/380) 1 entry
ENSG00000153944 MSI2 osteosarcoma sequence_alteration 0.8621% (1/116) 1 entry
ENSG00000153944 MSI2 primary peritoneal carcinoma (disease) missense_variant 100.0% (1/1) 1 entry
ENSG00000153944 MSI2 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000153944 MSI2 rectal adenocarcinoma stop_lost 0.4525% (1/221) 1 entry
ENSG00000153944 MSI2 small cell lung carcinoma sequence_alteration 0.3096% (1/323) 1 entry
ENSG00000153944 MSI2 oral squamous cell carcinoma missense_variant 2.927% (6/205) 1 entry
ENSG00000153944 MSI2 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000153944 MSI2 Ampulla of Vater Carcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000153944 MSI2 esophageal squamous cell carcinoma frameshift_variant 0.4444% (3/675) 1 entry
ENSG00000153944 MSI2 colon adenocarcinoma stop_gained 6.787% (49/722) 1 entry
ENSG00000153944 MSI2 acute lymphoblastic leukemia sequence_alteration 0.3115% (1/321) 1 entry
ENSG00000153944 MSI2 Mantle cell lymphoma sequence_alteration 2.439% (1/41) 1 entry
ENSG00000153944 MSI2 angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000153944 MSI2 UVM 0.023 high
ENSG00000153944 MSI2 ACC 0.021 high
ENSG00000153944 MSI2 LGG 0.00083 high
ENSG00000153944 MSI2 READ 0.005 low
ENSG00000153944 MSI2 KIRP 0.014 low
ENSG00000153944 MSI2 KICH 0.025 high
ENSG00000153944 MSI2 LUAD 0.021 low
ENSG00000153944 MSI2 PCPG 0.0012 high
ENSG00000153944 MSI2 THYM 0.00059 low
ENSG00000153944 MSI2 BRCA 0.04 high
ENSG00000153944 MSI2 COAD 0.035 low
ENSG00000153944 MSI2 ESCA 0.019 low
ENSG00000153944 MSI2 KIRC 0.0016 low
ENSG00000153944 MSI2 PRAD 0.026 low
ENSG00000153944 MSI2 TGCT 0.048 low
ENSG00000153944 MSI2 BLCA 0.0036 low
ENSG00000153944 MSI2 SKCM 0.0078 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000153944 MSI2 LGG Amp 1.895220 0.061374 0.572466 0.070175
ENSG00000153944 MSI2 PAAD Del 5.761314 0.125329 0.381251 0.250000
ENSG00000153944 MSI2 SKCM Amp 3.819240 0.212200 0.543966 0.321526
ENSG00000153944 MSI2 LIHC Amp 1.580565 0.136281 0.615228 0.332432
ENSG00000153944 MSI2 BLCA Amp 0.965569 0.174244 0.488034 0.426471
ENSG00000153944 MSI2 BRCA Amp 36.621379 0.465380 0.841754 0.354630