Ensembl ID ENSG00000153201 Gene ID 5903 Accession 9848
Gene Symbol RANBP2 Alias ANE1;TRP1;TRP2;ADANE;IIAE3;NUP358 Full Name RAN binding protein 2
Position 2 : 108719482 - 108785810 Length 66329 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

ENSG00000153201 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000153201 RANBP2 -0.7 1.27e-28 KIRC
ENSG00000153201 RANBP2 -0.9 3.00e-25 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000153201 RANBP2 inflammatory myofibroblastic tumor 12661011
ENSG00000153201 RANBP2 tumors 15382044
ENSG00000153201 RANBP2 tumor 16230384
ENSG00000153201 RANBP2 inflammatory myofibroblastic tumors 17656252
ENSG00000153201 RANBP2 tumor 18394551
ENSG00000153201 RANBP2 tumor 18394993
ENSG00000153201 RANBP2 inflammatory myofibroblastic tumor 18701132
ENSG00000153201 RANBP2 lung cancer 19809814
ENSG00000153201 RANBP2 cancer 22140466
ENSG00000153201 RANBP2 pancreatic cancers 23536549
ENSG00000153201 RANBP2 tumors 23684749
ENSG00000153201 RANBP2 tumor 23818861
ENSG00000153201 RANBP2 Inflammatory myofibroblastic tumor 24034896
ENSG00000153201 RANBP2 tumor 24113188
ENSG00000153201 RANBP2 cancer 24909165
ENSG00000153201 RANBP2 inflammatory myofibroblastic tumor 25028698
ENSG00000153201 RANBP2 cancer 25294810
ENSG00000153201 RANBP2 acute myeloid leukemia (AML) 25766836
ENSG00000153201 RANBP2 tumors 25888090
ENSG00000153201 RANBP2 tumor 26139079
ENSG00000153201 RANBP2 tumor 26178751
ENSG00000153201 RANBP2 breast cancer 26364603
ENSG00000153201 RANBP2 Inflammatory myofibroblastic tumor 26893756
ENSG00000153201 RANBP2 colorectal cancer 27203373
ENSG00000153201 RANBP2 tumor 27460384
ENSG00000153201 RANBP2 inflammatory myofibroblastic tumors 28415158
ENSG00000153201 RANBP2 cancer 28600321
ENSG00000153201 RANBP2 cancer 28882106
ENSG00000153201 RANBP2 cancer 29484374
ENSG00000153201 RANBP2 lung cancer 29706609
ENSG00000153201 RANBP2 cervical cancer 30678687
ENSG00000153201 RANBP2 cancer 31545242
ENSG00000153201 RANBP2 cancer 31712650
ENSG00000153201 RANBP2 inflammatory myofibroblastic tumor 31933992
ENSG00000153201 RANBP2 Wilms tumor 31949483
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000153201 RANBP2 colorectal adenocarcinoma missense_variant 4.921% (56/1138) 3 entries
ENSG00000153201 RANBP2 colorectal adenocarcinoma sequence_alteration 4.921% (56/1138) 1 entry
ENSG00000153201 RANBP2 colorectal adenocarcinoma stop_gained 4.921% (56/1138) 1 entry
ENSG00000153201 RANBP2 inflammatory myofibroblastic tumor gene_fusion 50.0% (20/40) 5 entries
ENSG00000153201 RANBP2 colorectal adenocarcinoma frameshift_variant 4.921% (56/1138) 1 entry
ENSG00000153201 RANBP2 cecum adenocarcinoma missense_variant 8.0% (10/125) 2 entries
ENSG00000153201 RANBP2 bladder transitional cell carcinoma missense_variant 2.19% (3/137) 1 entry
ENSG00000153201 RANBP2 colon adenocarcinoma frameshift_variant 3.74% (27/722) 2 entries
ENSG00000153201 RANBP2 HER2 Positive Breast Carcinoma missense_variant 4.43% (7/158) 1 entry
ENSG00000153201 RANBP2 clear cell renal carcinoma missense_variant 2.248% (29/1290) 1 entry
ENSG00000153201 RANBP2 lung adenocarcinoma missense_variant 2.541% (31/1220) 5 entries
ENSG00000153201 RANBP2 bile duct adenocarcinoma missense_variant 1.058% (2/189) 2 entries
ENSG00000153201 RANBP2 osteosarcoma missense_variant 2.586% (3/116) 1 entry
ENSG00000153201 RANBP2 cecum adenocarcinoma stop_gained 8.0% (10/125) 1 entry
ENSG00000153201 RANBP2 esophageal squamous cell carcinoma missense_variant 0.5926% (4/675) 2 entries
ENSG00000153201 RANBP2 large cell lung carcinoma missense_variant 16.67% (3/18) 2 entries
ENSG00000153201 RANBP2 gastric intestinal type adenocarcinoma missense_variant 5.882% (5/85) 1 entry
ENSG00000153201 RANBP2 brain glioblastoma sequence_alteration 0.432% (4/926) 2 entries
ENSG00000153201 RANBP2 colon adenocarcinoma sequence_alteration 3.74% (27/722) 1 entry
ENSG00000153201 RANBP2 basal cell carcinoma missense_variant 12.07% (7/58) 1 entry
ENSG00000153201 RANBP2 myeloproliferative disorder gene_fusion 25.0% (2/8) 1 entry
ENSG00000153201 RANBP2 gastric adenocarcinoma sequence_alteration 4.122% (23/558) 1 entry
ENSG00000153201 RANBP2 melanoma missense_variant 4.95% (5/101) 2 entries
ENSG00000153201 RANBP2 acute myeloid leukemia missense_variant 1.87% (17/909) 1 entry
ENSG00000153201 RANBP2 colon adenocarcinoma missense_variant 3.74% (27/722) 5 entries
ENSG00000153201 RANBP2 skin melanoma missense_variant 4.24% (41/967) 5 entries
ENSG00000153201 RANBP2 esophageal adenocarcinoma sequence_alteration 3.653% (16/438) 1 entry
ENSG00000153201 RANBP2 small cell lung carcinoma missense_variant 2.769% (9/325) 3 entries
ENSG00000153201 RANBP2 hepatocellular carcinoma missense_variant 1.778% (16/900) 2 entries
ENSG00000153201 RANBP2 skin melanoma sequence_alteration 4.24% (41/967) 1 entry
ENSG00000153201 RANBP2 adenosquamous lung carcinoma missense_variant 18.18% (2/11) 1 entry
ENSG00000153201 RANBP2 hemangioblastoma sequence_alteration 9.375% (3/32) 1 entry
ENSG00000153201 RANBP2 rectal adenocarcinoma stop_gained 3.167% (7/221) 1 entry
ENSG00000153201 RANBP2 prostate adenocarcinoma sequence_alteration 1.994% (29/1454) 1 entry
ENSG00000153201 RANBP2 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 2.339% (4/171) 1 entry
ENSG00000153201 RANBP2 esophageal adenocarcinoma missense_variant 3.653% (16/438) 1 entry
ENSG00000153201 RANBP2 squamous cell lung carcinoma missense_variant 2.424% (20/825) 2 entries
ENSG00000153201 RANBP2 prostate adenocarcinoma missense_variant 1.994% (29/1454) 1 entry
ENSG00000153201 RANBP2 skin melanoma stop_gained 4.24% (41/967) 1 entry
ENSG00000153201 RANBP2 nasopharyngeal squamous cell carcinoma missense_variant 1.796% (3/167) 2 entries
ENSG00000153201 RANBP2 clear cell renal carcinoma sequence_alteration 2.248% (29/1290) 1 entry
ENSG00000153201 RANBP2 rectal adenocarcinoma missense_variant 3.167% (7/221) 1 entry
ENSG00000153201 RANBP2 prostate carcinoma missense_variant 1.033% (5/484) 2 entries
ENSG00000153201 RANBP2 female breast carcinoma sequence_alteration 1.023% (4/391) 1 entry
ENSG00000153201 RANBP2 clear cell renal carcinoma stop_gained 2.248% (29/1290) 1 entry
ENSG00000153201 RANBP2 neoplasm of mature B-cells missense_variant 2.941% (1/34) 1 entry
ENSG00000153201 RANBP2 myelodysplastic syndrome gene_fusion 1.316% (1/76) 1 entry
ENSG00000153201 RANBP2 Cervical Small Cell Carcinoma missense_variant 33.33% (2/6) 1 entry
ENSG00000153201 RANBP2 prostate carcinoma sequence_alteration 1.033% (5/484) 1 entry
ENSG00000153201 RANBP2 Liver Inflammatory Myofibroblastic Tumor gene_fusion 50.0% (1/2) 1 entry
ENSG00000153201 RANBP2 gastric adenocarcinoma frameshift_variant 4.122% (23/558) 1 entry
ENSG00000153201 RANBP2 neoplasm of mature B-cells stop_gained 2.941% (1/34) 1 entry
ENSG00000153201 RANBP2 gastric intestinal type adenocarcinoma frameshift_variant 5.882% (5/85) 1 entry
ENSG00000153201 RANBP2 Juvenile Myelomonocytic Leukemia gene_fusion 50.0% (1/2) 1 entry
ENSG00000153201 RANBP2 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma stop_gained 2.339% (4/171) 1 entry
ENSG00000153201 RANBP2 endometrial carcinoma missense_variant 4.167% (1/24) 1 entry
ENSG00000153201 RANBP2 anaplastic astrocytoma missense_variant 2.222% (1/45) 1 entry
ENSG00000153201 RANBP2 clear cell renal carcinoma frameshift_variant 2.248% (29/1290) 1 entry
ENSG00000153201 RANBP2 Invasive Breast Carcinoma missense_variant 2.174% (1/46) 1 entry
ENSG00000153201 RANBP2 colon carcinoma missense_variant 12.5% (1/8) 1 entry
ENSG00000153201 RANBP2 Pleural Epithelioid Mesothelioma missense_variant 1.064% (1/94) 1 entry
ENSG00000153201 RANBP2 Cervical Small Cell Carcinoma sequence_alteration 33.33% (2/6) 1 entry
ENSG00000153201 RANBP2 basal cell carcinoma frameshift_variant 12.07% (7/58) 1 entry
ENSG00000153201 RANBP2 acute lymphoblastic leukemia missense_variant 0.3115% (1/321) 1 entry
ENSG00000153201 RANBP2 angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000153201 RANBP2 gastric intestinal type adenocarcinoma conservative_inframe_deletion 5.882% (5/85) 1 entry
ENSG00000153201 RANBP2 diffuse large B-cell lymphoma amino_acid_insertion 0.9901% (3/303) 1 entry
ENSG00000153201 RANBP2 Uterine Carcinosarcoma missense_variant 2.727% (3/110) 1 entry
ENSG00000153201 RANBP2 esophageal adenocarcinoma frameshift_variant 3.653% (16/438) 1 entry
ENSG00000153201 RANBP2 nasopharyngeal squamous cell carcinoma stop_gained 1.796% (3/167) 1 entry
ENSG00000153201 RANBP2 lung adenocarcinoma stop_gained 2.541% (31/1220) 1 entry
ENSG00000153201 RANBP2 diffuse large B-cell lymphoma stop_gained 0.9901% (3/303) 1 entry
ENSG00000153201 RANBP2 laryngeal squamous cell carcinoma missense_variant 3.846% (1/26) 1 entry
ENSG00000153201 RANBP2 female breast carcinoma frameshift_variant 1.023% (4/391) 1 entry
ENSG00000153201 RANBP2 skin melanoma frameshift_variant 4.24% (41/967) 1 entry
ENSG00000153201 RANBP2 rectal adenocarcinoma frameshift_variant 3.167% (7/221) 1 entry
ENSG00000153201 RANBP2 laryngeal squamous cell carcinoma sequence_alteration 3.846% (1/26) 1 entry
ENSG00000153201 RANBP2 diffuse large B-cell lymphoma missense_variant 0.9901% (3/303) 1 entry
ENSG00000153201 RANBP2 Pleural Biphasic Mesothelioma missense_variant 3.333% (1/30) 1 entry
ENSG00000153201 RANBP2 papillary thyroid carcinoma missense_variant 0.2532% (1/395) 1 entry
ENSG00000153201 RANBP2 Gallbladder Adenocarcinoma sequence_alteration 1.149% (1/87) 1 entry
ENSG00000153201 RANBP2 brain glioblastoma missense_variant 0.432% (4/926) 1 entry
ENSG00000153201 RANBP2 Retroperitoneal Inflammatory Myofibroblastic Tumor gene_fusion 50.0% (1/2) 1 entry
ENSG00000153201 RANBP2 Kidney Oncocytoma missense_variant 3.125% (1/32) 1 entry
ENSG00000153201 RANBP2 Merkel cell skin cancer missense_variant 3.226% (1/31) 1 entry
ENSG00000153201 RANBP2 non-small cell lung carcinoma missense_variant 1.613% (1/62) 1 entry
ENSG00000153201 RANBP2 osteosarcoma sequence_alteration 2.586% (3/116) 1 entry
ENSG00000153201 RANBP2 acute myeloid leukemia gene_fusion 1.87% (17/909) 1 entry
ENSG00000153201 RANBP2 metaplastic breast carcinoma missense_variant 3.922% (2/51) 1 entry
ENSG00000153201 RANBP2 Pancreatic Acinar Cell Carcinoma missense_variant 5.0% (1/20) 1 entry
ENSG00000153201 RANBP2 Ampulla of Vater Carcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000153201 RANBP2 female breast carcinoma missense_variant 1.023% (4/391) 1 entry
ENSG00000153201 RANBP2 chronic lymphocytic leukemia frameshift_variant 0.2252% (2/888) 1 entry
ENSG00000153201 RANBP2 oral squamous cell carcinoma missense_variant 0.4878% (1/205) 1 entry
ENSG00000153201 RANBP2 head and neck squamous cell carcinoma missense_variant 0.1597% (1/626) 1 entry
ENSG00000153201 RANBP2 hemangioblastoma missense_variant 9.375% (3/32) 1 entry
ENSG00000153201 RANBP2 T-cell acute lymphoblastic leukemia missense_variant 0.2632% (1/380) 1 entry
ENSG00000153201 RANBP2 hepatocellular carcinoma frameshift_variant 1.778% (16/900) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000153201 RANBP2 PAAD 0.036 low
ENSG00000153201 RANBP2 THCA 0.027 high
ENSG00000153201 RANBP2 ACC 0.0053 high
ENSG00000153201 RANBP2 LGG 0.0013 high
ENSG00000153201 RANBP2 READ 0.0042 low
ENSG00000153201 RANBP2 KIRP 0.027 high
ENSG00000153201 RANBP2 KICH 0.022 high
ENSG00000153201 RANBP2 PCPG 0.0089 high
ENSG00000153201 RANBP2 DLBC 0.033 high
ENSG00000153201 RANBP2 PRAD 0.031 high
ENSG00000153201 RANBP2 GBM 0.0072 low
ENSG00000153201 RANBP2 SKCM 0.00085 low
ENSG00000153201 RANBP2 CESC 0.027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency