Ensembl ID ENSG00000153113 Gene ID 831 Accession 1515
Gene Symbol CAST Alias BS-17;PLACK Full Name calpastatin
Position 5 : 96529821 - 96779595 Length 249775 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

ENSG00000153113 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000153113 -1.0 7.56e-29 HNSC
ENSG00000153113 -0.5 1.32e-19 BRCA
ENSG00000153113 -0.8 2.08e-19 COAD
ENSG00000153113 -0.9 9.87e-15 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000153113 tumor 10845425
ENSG00000153113 tumor 10873099
ENSG00000153113 pituitary tumor 11192619
ENSG00000153113 tumour 11286475
ENSG00000153113 ovarian cancer 11319608
ENSG00000153113 breast tumors 12569370
ENSG00000153113 tumor 12851726
ENSG00000153113 tumor 12907643
ENSG00000153113 colon cancer 15120327
ENSG00000153113 tumor 15297395
ENSG00000153113 colon tumor 15466976
ENSG00000153113 cancer 16472152
ENSG00000153113 tumor 16865282
ENSG00000153113 gastric cancer 17971859
ENSG00000153113 cancer 18492780
ENSG00000153113 tumors 19946123
ENSG00000153113 endometrial cancer 20683020
ENSG00000153113 tumours 21140455
ENSG00000153113 cancer 21305563
ENSG00000153113 cancer 21508973
ENSG00000153113 breast cancer 21531560
ENSG00000153113 ovarian cancer 22335024
ENSG00000153113 tumours 22435971
ENSG00000153113 tumour 22745213
ENSG00000153113 breast cancer 22753709
ENSG00000153113 pancreatic cancers 23140395
ENSG00000153113 cancer 23145836
ENSG00000153113 cancer 23329366
ENSG00000153113 cancer 23389291
ENSG00000153113 tumor 23565252
ENSG00000153113 breast cancer 23684705
ENSG00000153113 breast cancer 24553345
ENSG00000153113 gastric cancer 24589339
ENSG00000153113 gastric cancer 25226618
ENSG00000153113 colon cancer 25319833
ENSG00000153113 cancer 25399719
ENSG00000153113 cancer 25629974
ENSG00000153113 cancer 25714701
ENSG00000153113 prostate cancer 25879420
ENSG00000153113 Cancer 25881607
ENSG00000153113 cancer 26077418
ENSG00000153113 HNSCC 26132406
ENSG00000153113 pancreatic cancer 26138287
ENSG00000153113 prostate cancer 26302712
ENSG00000153113 cancer 26317226
ENSG00000153113 tumor 26893741
ENSG00000153113 breast cancer 27323818
ENSG00000153113 laryngeal cancer 27456359
ENSG00000153113 breast cancer 27473585
ENSG00000153113 pancreatic cancer 27487486
ENSG00000153113 Ovarian Cancer 27793894
ENSG00000153113 breast cancer 27798717
ENSG00000153113 tumor 28112357
ENSG00000153113 tumor 28469577
ENSG00000153113 prostate cancer 28498452
ENSG00000153113 tumors 28512118
ENSG00000153113 gastric cancer 28927135
ENSG00000153113 tumor 29069832
ENSG00000153113 cancer 29210197
ENSG00000153113 cancer 29581866
ENSG00000153113 Tumor 29599325
ENSG00000153113 tumor 29785246
ENSG00000153113 tumour 30448882
ENSG00000153113 brain tumor 30959065
ENSG00000153113 breast cancer 31000696
ENSG00000153113 tumor 31425704
ENSG00000153113 breast cancer 9216645
ENSG00000153113 breast cancer 9353308
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000153113 MESO 0.001 low
ENSG00000153113 SARC 0.0087 low
ENSG00000153113 CHOL 0.023 low
ENSG00000153113 UVM 0.00076 high
ENSG00000153113 PAAD 1e-04 high
ENSG00000153113 UCEC 0.005 high
ENSG00000153113 THCA 0.041 low
ENSG00000153113 ACC 0.0061 low
ENSG00000153113 LUSC 0.011 high
ENSG00000153113 READ 0.016 low
ENSG00000153113 KIRP 0.011 high
ENSG00000153113 KICH 0.021 high
ENSG00000153113 LUAD 0.024 high
ENSG00000153113 THYM 0.0015 high
ENSG00000153113 UCS 0.0052 high
ENSG00000153113 OV 0.004 high
ENSG00000153113 DLBC 0.032 high
ENSG00000153113 KIRC 0.00077 low
ENSG00000153113 PRAD 0.0017 low
ENSG00000153113 LAML 0.045 high
ENSG00000153113 CESC 0.036 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000153113 LUSC Del 1.624054 0.078444 0.400821 0.774451
ENSG00000153113 LAML Del 4.100632 0.071421 0.797289 0.073298
ENSG00000153113 LUAD Del 2.093825 0.068190 0.342636 0.405039
ENSG00000153113 COAD Del 10.218988 0.114026 0.429321 0.268293
ENSG00000153113 PAAD Del 0.629122 0.043541 0.310463 0.157609
ENSG00000153113 HNSC Del 2.079559 0.069066 0.388392 0.415709
ENSG00000153113 BLCA Del 0.983275 0.082260 0.395437 0.475490
ENSG00000153113 BRCA Del 1.697553 0.072277 0.440407 0.255556
ENSG00000153113 STAD Del 6.640280 0.122013 0.398770 0.367347
ENSG00000153113 PRAD Del 10.906788 0.154696 0.527997 0.174797
ENSG00000153113 UCEC Del 2.443627 0.067490 0.472075 0.196660
ENSG00000153113 KIRC Amp 3.981812 0.063662 0.504044 0.418561
ENSG00000153113 OV Del 36.588476 0.490278 0.631004 0.630397