Ensembl ID ENSG00000152670 Gene ID 54514 Accession 18700
Gene Symbol DDX4 Alias VASA Full Name DEAD-box helicase 4
Position 5 : 55738017 - 55817157 Length 79141 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

ENSG00000152670 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000152670 DDX4 2.73 3.57e-15 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000152670 DDX4 germ cell tumors 11850529
ENSG00000152670 DDX4 germ cell tumours 16273510
ENSG00000152670 DDX4 cancer 18694875
ENSG00000152670 DDX4 epithelial ovarian cancer 18805576
ENSG00000152670 DDX4 ovarian cancers 24727449
ENSG00000152670 DDX4 tumor 25844678
ENSG00000152670 DDX4 TGCT 26843623
ENSG00000152670 DDX4 cancer 28612512
ENSG00000152670 DDX4 cancer 28625975
ENSG00000152670 DDX4 tumor 29078734
ENSG00000152670 DDX4 ovarian cancer 29963162
ENSG00000152670 DDX4 cancer 30380781
ENSG00000152670 DDX4 Ovarian Cancer 31336813
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000152670 DDX4 CHOL 0.0014 high
ENSG00000152670 DDX4 THCA 0.046 high
ENSG00000152670 DDX4 HNSC 0.036 low
ENSG00000152670 DDX4 THYM 0.021 high
ENSG00000152670 DDX4 UCS 0.042 high
ENSG00000152670 DDX4 ESCA 0.02 high
ENSG00000152670 DDX4 OV 0.033 low
ENSG00000152670 DDX4 PRAD 0.018 low
ENSG00000152670 DDX4 CESC 0.028 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000152670 DDX4 LUSC Del 3.400404 0.098108 0.399917 0.728543
ENSG00000152670 DDX4 LUAD Del 1.071492 0.056440 0.339616 0.310078
ENSG00000152670 DDX4 CESC Del 0.956914 0.072299 0.456735 0.240678
ENSG00000152670 DDX4 COAD Del 2.539473 0.061214 0.391728 0.217295
ENSG00000152670 DDX4 UCS Del 2.011302 0.307395 0.573757 0.375000
ENSG00000152670 DDX4 PAAD Del 1.079421 0.053544 0.340221 0.157609
ENSG00000152670 DDX4 ESCA Del 1.763185 0.126505 0.432150 0.581522
ENSG00000152670 DDX4 HNSC Del 3.797106 0.083376 0.390211 0.379310
ENSG00000152670 DDX4 BLCA Del 4.340375 0.126840 0.395944 0.460784
ENSG00000152670 DDX4 BRCA Del 7.743656 0.105558 0.465237 0.246296
ENSG00000152670 DDX4 STAD Del 3.097573 0.090835 0.389082 0.326531
ENSG00000152670 DDX4 PRAD Del 23.826112 0.222031 0.591769 0.199187
ENSG00000152670 DDX4 UCEC Del 10.328791 0.121924 0.541442 0.189239
ENSG00000152670 DDX4 OV Del 42.070484 0.521691 0.670154 0.556131