Ensembl ID
ENSG00000150753
Gene ID
22948
Accession
1618
Gene Symbol
CCT5
Alias
CCTE;HEL-S-69;PNAS-102;CCT-epsilon;TCP-1-epsilon
Full Name
chaperonin containing TCP1 subunit 5
Position
5 : 10249929 - 10266389
Length
16461 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
ENSG00000150753 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000150753
0.71
1.22e-15
HNSC
ENSG00000150753
0.89
1.03e-40
BRCA
ENSG00000150753
0.77
9.53e-24
COAD
ENSG00000150753
1.79
6.02e-76
LUSC
ENSG00000150753
0.67
8.17e-15
LIHC
ENSG00000150753
0.78
4.97e-12
STAD
ENSG00000150753
1.08
1.77e-22
UCEC
ENSG00000150753
1.25
8.42e-34
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000150753
breast cancers
16821082
ENSG00000150753
colorectal cancer
16981251
ENSG00000150753
cancer
23282132
ENSG00000150753
tumor
28969060
ENSG00000150753
tumours
29954368
ENSG00000150753
tumor
31934176
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000150753
SARC
0.00032
high
show
ENSG00000150753
UVM
0.00042
high
show
ENSG00000150753
PAAD
0.01
high
show
ENSG00000150753
ACC
0.00017
high
show
ENSG00000150753
LGG
0.0026
high
show
ENSG00000150753
LUSC
0.032
low
show
ENSG00000150753
HNSC
0.002
high
show
ENSG00000150753
READ
0.023
low
show
ENSG00000150753
LUAD
0.0027
high
show
ENSG00000150753
THYM
0.01
low
show
ENSG00000150753
BRCA
0.0058
high
show
ENSG00000150753
OV
0.0022
low
show
ENSG00000150753
DLBC
0.011
low
show
ENSG00000150753
KIRC
0.00021
high
show
ENSG00000150753
PRAD
0.012
high
show
ENSG00000150753
BLCA
0.019
high
show
ENSG00000150753
LAML
0.039
high
show
ENSG00000150753
SKCM
0.03
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000150753
LUSC
Amp
11.544047
0.423263
0.859282
0.766467
ENSG00000150753
LUAD
Amp
12.046860
0.302391
0.750592
0.620155
ENSG00000150753
LGG
Del
1.013479
0.042631
0.494572
0.081871
ENSG00000150753
CESC
Amp
1.952919
0.177243
0.950739
0.457627
ENSG00000150753
ACC
Amp
0.627773
0.237544
1.354006
0.588889
ENSG00000150753
SARC
Amp
1.492405
0.305072
0.792492
0.463035
ENSG00000150753
SKCM
Amp
1.805365
0.156098
0.698409
0.245232
ENSG00000150753
SKCM
Del
1.438641
0.078470
0.466953
0.217984
ENSG00000150753
HNSC
Amp
0.646699
0.113772
0.654811
0.452107
ENSG00000150753
BLCA
Amp
3.806438
0.260857
0.816176
0.504902
ENSG00000150753
UCEC
Amp
1.664195
0.125991
0.844943
0.144712
ENSG00000150753
OV
Amp
3.428972
0.414276
0.884622
0.506045
Copyright © 2023, Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.