Ensembl ID ENSG00000149925 Gene ID 226 Accession 414
Gene Symbol ALDOA Alias ALDA;GSD12;HEL-S-87p Full Name aldolase, fructose-bisphosphate A
Position 16 : 30064172 - 30070417 Length 6246 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]

ENSG00000149925 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000149925 ALDOA 1.10 2.97e-50 KIRC
ENSG00000149925 ALDOA 1.19 3.92e-50 BRCA
ENSG00000149925 ALDOA 1.44 9.22e-37 KICH
ENSG00000149925 ALDOA 1.36 8.63e-51 LUSC
ENSG00000149925 ALDOA 1.09 2.22e-16 KIRP
ENSG00000149925 ALDOA 1.11 1.13e-13 LIHC
ENSG00000149925 ALDOA 1.22 5.62e-21 UCEC
ENSG00000149925 ALDOA 2.22 3.08e-15 CHOL
ENSG00000149925 ALDOA 1.17 1.63e-28 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000149925 ALDOA tumor 16714762
ENSG00000149925 ALDOA pancreatic cancer 19077459
ENSG00000149925 ALDOA lung cancer 19412661
ENSG00000149925 ALDOA tumour 20884743
ENSG00000149925 ALDOA Breast cancer 21875443
ENSG00000149925 ALDOA cancer 231001
ENSG00000149925 ALDOA cancer 23216862
ENSG00000149925 ALDOA tumor 23821767
ENSG00000149925 ALDOA squamous cell lung cancer 23886627
ENSG00000149925 ALDOA tumor 24203292
ENSG00000149925 ALDOA lung cancer 24450150
ENSG00000149925 ALDOA tumor 24465716
ENSG00000149925 ALDOA tumors 25215901
ENSG00000149925 ALDOA cancer 25243088
ENSG00000149925 ALDOA gastric cancer 25379943
ENSG00000149925 ALDOA tumor 25687883
ENSG00000149925 ALDOA colon cancer 26169282
ENSG00000149925 ALDOA tumor 26590260
ENSG00000149925 ALDOA pancreatic cancer 26854714
ENSG00000149925 ALDOA tumor 27128972
ENSG00000149925 ALDOA cancer 27261507
ENSG00000149925 ALDOA tumors 27741516
ENSG00000149925 ALDOA colorectal cancer 28000858
ENSG00000149925 ALDOA tumors 28191039
ENSG00000149925 ALDOA tumor 28225015
ENSG00000149925 ALDOA tumor 28280347
ENSG00000149925 ALDOA lung cancer 28610954
ENSG00000149925 ALDOA cancers 28686225
ENSG00000149925 ALDOA tumors 28820953
ENSG00000149925 ALDOA tumor 29084207
ENSG00000149925 ALDOA pancreatic cancer 29546614
ENSG00000149925 ALDOA Gastric Cancer 29554660
ENSG00000149925 ALDOA cancer 29657328
ENSG00000149925 ALDOA tumor 29693182
ENSG00000149925 ALDOA cancers 29764507
ENSG00000149925 ALDOA colorectal cancer 29988738
ENSG00000149925 ALDOA tumor 29992789
ENSG00000149925 ALDOA bile duct cancer 30121648
ENSG00000149925 ALDOA liver cancer 30430110
ENSG00000149925 ALDOA breast cancer 30873026
ENSG00000149925 ALDOA tumors 30967137
ENSG00000149925 ALDOA Tumor 31041640
ENSG00000149925 ALDOA bladder cancer 31081974
ENSG00000149925 ALDOA cancer 31268712
ENSG00000149925 ALDOA lung cancer 31358528
ENSG00000149925 ALDOA Cancer 31384177
ENSG00000149925 ALDOA colon cancer 31423171
ENSG00000149925 ALDOA cancer 31558701
ENSG00000149925 ALDOA Colon Cancer 31564215
ENSG00000149925 ALDOA lung cancer 31601833
ENSG00000149925 ALDOA cancer 31646071
ENSG00000149925 ALDOA cervical cancer 31819523
ENSG00000149925 ALDOA tumor 3985636
ENSG00000149925 ALDOA liver tumor 4310151
ENSG00000149925 ALDOA cancer 7429085
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000149925 ALDOA UVM 0.0087 high
ENSG00000149925 ALDOA PAAD 0.019 high
ENSG00000149925 ALDOA THCA 0.0038 high
ENSG00000149925 ALDOA ACC 0.026 low
ENSG00000149925 ALDOA LGG 1e-04 low
ENSG00000149925 ALDOA HNSC 0.0038 high
ENSG00000149925 ALDOA PCPG 0.011 low
ENSG00000149925 ALDOA THYM 0.00046 high
ENSG00000149925 ALDOA BRCA 0.016 high
ENSG00000149925 ALDOA COAD 0.031 high
ENSG00000149925 ALDOA DLBC 0.038 low
ENSG00000149925 ALDOA BLCA 0.031 high
ENSG00000149925 ALDOA LAML 0.0021 high
ENSG00000149925 ALDOA GBM 0.0077 high
ENSG00000149925 ALDOA SKCM 0.015 high
ENSG00000149925 ALDOA CESC 0.03 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency