Ensembl ID ENSG00000149792 Gene ID 740 Accession 1176
Gene Symbol MRPL49 Alias NOF;NOF1;mL49;L49mt;C11orf4;MRP-L49 Full Name mitochondrial ribosomal protein L49
Position 11 : 65122311 - 65127371 Length 5061 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]

ENSG00000149792 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000149792 MRPL49 -0.6 1.01e-25 KIRC
ENSG00000149792 MRPL49 0.47 1.70e-20 BRCA
ENSG00000149792 MRPL49 -0.5 6.28e-12 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000149792 MRPL49 tumor 11332712
ENSG00000149792 MRPL49 ovarian tumor 18448156
ENSG00000149792 MRPL49 tumour 24254977
ENSG00000149792 MRPL49 tumour 25345775
ENSG00000149792 MRPL49 cancer 28697787
ENSG00000149792 MRPL49 tumour 28871211
ENSG00000149792 MRPL49 oral cancer 29046763
ENSG00000149792 MRPL49 ovarian cancer 29221185
ENSG00000149792 MRPL49 ovarian cancer 29348860
ENSG00000149792 MRPL49 cancer 29360827
ENSG00000149792 MRPL49 AML 29781401
ENSG00000149792 MRPL49 tumour 30465648
ENSG00000149792 MRPL49 tumour 30788085
ENSG00000149792 MRPL49 cancer 31270582
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000149792 MRPL49 MESO 0.00068 low
ENSG00000149792 MRPL49 SARC 0.035 low
ENSG00000149792 MRPL49 STAD 0.0089 low
ENSG00000149792 MRPL49 PAAD 0.0015 high
ENSG00000149792 MRPL49 THCA 0.045 low
ENSG00000149792 MRPL49 LGG 0.0018 high
ENSG00000149792 MRPL49 READ 0.025 low
ENSG00000149792 MRPL49 KIRP 0.00054 low
ENSG00000149792 MRPL49 PCPG 0.019 high
ENSG00000149792 MRPL49 THYM 0.012 low
ENSG00000149792 MRPL49 BRCA 6e-04 high
ENSG00000149792 MRPL49 UCS 0.028 low
ENSG00000149792 MRPL49 OV 0.013 low
ENSG00000149792 MRPL49 TGCT 0.011 high
ENSG00000149792 MRPL49 BLCA 0.021 high
ENSG00000149792 MRPL49 GBM 0.039 high
ENSG00000149792 MRPL49 SKCM 0.0011 low
ENSG00000149792 MRPL49 CESC 0.014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000149792 MRPL49 SKCM Del 0.941250 0.070505 0.446056 0.354223
ENSG00000149792 MRPL49 BRCA Del 4.914250 0.092226 0.439424 0.225000