Ensembl ID ENSG00000148584 Gene ID 29974 Accession 24086
Gene Symbol A1CF Alias ACF;ASP;ACF64;ACF65;APOBEC1CF Full Name APOBEC1 complementation factor
Position 10 : 50799409 - 50885675 Length 86267 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

ENSG00000148584 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000148584 A1CF -1.2 3.01e-12 COAD
ENSG00000148584 A1CF -8.0 2.31e-67 KICH
ENSG00000148584 A1CF 2.74 4.63e-12 PRAD
ENSG00000148584 A1CF -1.0 1.03e-14 LIHC
ENSG00000148584 A1CF 3.61 1.71e-17 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000148584 A1CF tumor 10330400
ENSG00000148584 A1CF colon tumor 10395625
ENSG00000148584 A1CF tumor 10464717
ENSG00000148584 A1CF colorectal cancer 10652634
ENSG00000148584 A1CF tumors 10708483
ENSG00000148584 A1CF colon cancer 10965019
ENSG00000148584 A1CF tumour 10989943
ENSG00000148584 A1CF colorectal tumors 11212223
ENSG00000148584 A1CF colon cancers 11216473
ENSG00000148584 A1CF tumor 11431334
ENSG00000148584 A1CF cancer 11522744
ENSG00000148584 A1CF tumors 11588891
ENSG00000148584 A1CF colonic tumors 11819677
ENSG00000148584 A1CF colorectal tumor 11819789
ENSG00000148584 A1CF cancers 11866955
ENSG00000148584 A1CF cancer 11891526
ENSG00000148584 A1CF colon cancer 11911260
ENSG00000148584 A1CF colon cancers 11966532
ENSG00000148584 A1CF colorectal cancer 12000733
ENSG00000148584 A1CF tumours 12017282
ENSG00000148584 A1CF tumors 12066215
ENSG00000148584 A1CF colon cancer 12148579
ENSG00000148584 A1CF tumor 12433708
ENSG00000148584 A1CF tumor 12496057
ENSG00000148584 A1CF tumor 12506032
ENSG00000148584 A1CF tumor 12579275
ENSG00000148584 A1CF tumors 12628516
ENSG00000148584 A1CF HNSCC 12771912
ENSG00000148584 A1CF tumor 12800233
ENSG00000148584 A1CF cancer 12893429
ENSG00000148584 A1CF colorectal cancer 14610314
ENSG00000148584 A1CF tumors 15022301
ENSG00000148584 A1CF cancer 15374946
ENSG00000148584 A1CF tumor 15377995
ENSG00000148584 A1CF tumor 15488141
ENSG00000148584 A1CF tumor 15499611
ENSG00000148584 A1CF colon cancer 15536336
ENSG00000148584 A1CF colon cancers 15683997
ENSG00000148584 A1CF tumors 15751047
ENSG00000148584 A1CF colorectal cancer 15767337
ENSG00000148584 A1CF tumors 15896454
ENSG00000148584 A1CF cancer 15928667
ENSG00000148584 A1CF cancer 16012995
ENSG00000148584 A1CF tumors 16094649
ENSG00000148584 A1CF colon cancers 16136044
ENSG00000148584 A1CF colorectal cancer 16219426
ENSG00000148584 A1CF cancer 16298038
ENSG00000148584 A1CF cancer 16475686
ENSG00000148584 A1CF colon cancer 16740703
ENSG00000148584 A1CF colon cancer 16898869
ENSG00000148584 A1CF tumor 17012770
ENSG00000148584 A1CF tumors 17066439
ENSG00000148584 A1CF tumor 17118177
ENSG00000148584 A1CF colorectal tumors 17478078
ENSG00000148584 A1CF tumor 17823781
ENSG00000148584 A1CF tumor 17827685
ENSG00000148584 A1CF tumors 17847023
ENSG00000148584 A1CF colon cancer 17893236
ENSG00000148584 A1CF tumor 18080767
ENSG00000148584 A1CF tumors 18366456
ENSG00000148584 A1CF tumor 18413814
ENSG00000148584 A1CF cancers 18559541
ENSG00000148584 A1CF colon cancer 18615192
ENSG00000148584 A1CF tumor 18681964
ENSG00000148584 A1CF colon cancer 18754663
ENSG00000148584 A1CF colon cancer 19028703
ENSG00000148584 A1CF tumor 19029948
ENSG00000148584 A1CF tumor 19138933
ENSG00000148584 A1CF colon cancer 19139018
ENSG00000148584 A1CF colon cancer 19173288
ENSG00000148584 A1CF cancer 19247180
ENSG00000148584 A1CF tumor 19332896
ENSG00000148584 A1CF colon cancer 19358283
ENSG00000148584 A1CF colon cancer 19497424
ENSG00000148584 A1CF colon cancers 19568688
ENSG00000148584 A1CF intestine tumors 19758446
ENSG00000148584 A1CF cancer 20346115
ENSG00000148584 A1CF colon cancer 2044203
ENSG00000148584 A1CF cancer 20493508
ENSG00000148584 A1CF colon cancer 20511675
ENSG00000148584 A1CF colon cancer 20525330
ENSG00000148584 A1CF tumor 20549101
ENSG00000148584 A1CF tumors 20885960
ENSG00000148584 A1CF colon cancer 21246838
ENSG00000148584 A1CF tumours 21253581
ENSG00000148584 A1CF colon cancer 21406072
ENSG00000148584 A1CF tumors 21437179
ENSG00000148584 A1CF tumor 21483655
ENSG00000148584 A1CF tumor 21508209
ENSG00000148584 A1CF rectal cancer 21744313
ENSG00000148584 A1CF colon cancer 21765608
ENSG00000148584 A1CF tumors 21858154
ENSG00000148584 A1CF esophageal tumors 22279681
ENSG00000148584 A1CF colon cancer 22495988
ENSG00000148584 A1CF colorectal cancer 22564437
ENSG00000148584 A1CF cancer 22570753
ENSG00000148584 A1CF tumors 22624014
ENSG00000148584 A1CF colonic tumors 23118901
ENSG00000148584 A1CF colon cancer 23209640
ENSG00000148584 A1CF colon cancer 23226526
ENSG00000148584 A1CF tumor 23291777
ENSG00000148584 A1CF tumor 23443232
ENSG00000148584 A1CF colon cancer 23457494
ENSG00000148584 A1CF tumor 23560112
ENSG00000148584 A1CF tumor 23717604
ENSG00000148584 A1CF colorectal cancers 23730936
ENSG00000148584 A1CF tumours 23784081
ENSG00000148584 A1CF colon cancers 23914051
ENSG00000148584 A1CF tumor 23928829
ENSG00000148584 A1CF colon cancer 24224098
ENSG00000148584 A1CF tumor 24249972
ENSG00000148584 A1CF colon cancer 24278588
ENSG00000148584 A1CF colon cancer 24281183
ENSG00000148584 A1CF tumor 24408928
ENSG00000148584 A1CF tumor 24526805
ENSG00000148584 A1CF colon cancer 24552495
ENSG00000148584 A1CF colorectal cancer 24617038
ENSG00000148584 A1CF cancer 24618844
ENSG00000148584 A1CF cancer 24692283
ENSG00000148584 A1CF tumors 24827115
ENSG00000148584 A1CF tumors 24867956
ENSG00000148584 A1CF breast cancer 2494947
ENSG00000148584 A1CF tumor 24982368
ENSG00000148584 A1CF tumor 25089658
ENSG00000148584 A1CF colon cancer 25250322
ENSG00000148584 A1CF cancer 25314065
ENSG00000148584 A1CF tumors 25329503
ENSG00000148584 A1CF tumor 25368247
ENSG00000148584 A1CF colorectal cancer 25390042
ENSG00000148584 A1CF tumor 25836260
ENSG00000148584 A1CF colon cancer 25859284
ENSG00000148584 A1CF tumours 26075268
ENSG00000148584 A1CF colon cancer 26201720
ENSG00000148584 A1CF colon cancer 26251570
ENSG00000148584 A1CF colon tumor 26434820
ENSG00000148584 A1CF Colon cancer 26470793
ENSG00000148584 A1CF tumors 26566853
ENSG00000148584 A1CF tumour 26608653
ENSG00000148584 A1CF tumor 26657503
ENSG00000148584 A1CF colorectal cancer 26661587
ENSG00000148584 A1CF cancers 26709971
ENSG00000148584 A1CF tumors 26840292
ENSG00000148584 A1CF tumor 27086921
ENSG00000148584 A1CF breast cancer 27231908
ENSG00000148584 A1CF tumor 27461646
ENSG00000148584 A1CF tumors 27468227
ENSG00000148584 A1CF colon cancer 27490566
ENSG00000148584 A1CF testicular germ-cell tumors 27582469
ENSG00000148584 A1CF tumor 27602954
ENSG00000148584 A1CF tumors 27774065
ENSG00000148584 A1CF tumors 27806694
ENSG00000148584 A1CF colon cancer 27831561
ENSG00000148584 A1CF tumours 27835986
ENSG00000148584 A1CF cancer 27987431
ENSG00000148584 A1CF colorectal cancer 28380450
ENSG00000148584 A1CF intestinal tumors 28426718
ENSG00000148584 A1CF cancer 28459462
ENSG00000148584 A1CF tumor 28655889
ENSG00000148584 A1CF cancers 28747693
ENSG00000148584 A1CF cancer 28747791
ENSG00000148584 A1CF malignant tumors 28911405
ENSG00000148584 A1CF tumor 29018212
ENSG00000148584 A1CF colon cancer 29028945
ENSG00000148584 A1CF tumor 29097800
ENSG00000148584 A1CF tumours 29122850
ENSG00000148584 A1CF colorectal cancer 29222172
ENSG00000148584 A1CF tumor 29290650
ENSG00000148584 A1CF cancer 29393387
ENSG00000148584 A1CF tumor 29422806
ENSG00000148584 A1CF colon cancer 29442390
ENSG00000148584 A1CF cancer 29466973
ENSG00000148584 A1CF colon cancer 30038898
ENSG00000148584 A1CF tumor 30116994
ENSG00000148584 A1CF cancers 30123821
ENSG00000148584 A1CF colorectal cancer 30200383
ENSG00000148584 A1CF colon cancer 30207495
ENSG00000148584 A1CF colon cancer 30245714
ENSG00000148584 A1CF colorectal cancer 30319939
ENSG00000148584 A1CF Wilms tumor 30825095
ENSG00000148584 A1CF tumour 31104122
ENSG00000148584 A1CF colon cancer 31182925
ENSG00000148584 A1CF tumor 31186064
ENSG00000148584 A1CF breast cancer 3143311
ENSG00000148584 A1CF tumour 31451756
ENSG00000148584 A1CF tumor 31508270
ENSG00000148584 A1CF colon cancer 31509964
ENSG00000148584 A1CF cancers 31540047
ENSG00000148584 A1CF tumor 31588260
ENSG00000148584 A1CF cancer 31746153
ENSG00000148584 A1CF colorectal cancer 31754633
ENSG00000148584 A1CF tumor 31881249
ENSG00000148584 A1CF breast cancer 6790641
ENSG00000148584 A1CF colonic tumors 7750087
ENSG00000148584 A1CF colorectal cancer 7889486
ENSG00000148584 A1CF colorectal cancer 7923190
ENSG00000148584 A1CF colonic tumors 8149495
ENSG00000148584 A1CF cancer 8601574
ENSG00000148584 A1CF colon tumors 8657180
ENSG00000148584 A1CF colon cancer 8778329
ENSG00000148584 A1CF colon cancer 8968080
ENSG00000148584 A1CF colonic tumors 9097977
ENSG00000148584 A1CF tumor 9163680
ENSG00000148584 A1CF colon cancer 9500189
ENSG00000148584 A1CF tumours 9649126
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000148584 A1CF Merkel cell skin cancer sequence_alteration 10.0% (3/30) 1 entry
ENSG00000148584 A1CF basal cell carcinoma missense_variant 18.97% (11/58) 1 entry
ENSG00000148584 A1CF lung adenocarcinoma sequence_alteration 1.634% (19/1163) 5 entries
ENSG00000148584 A1CF colorectal adenocarcinoma missense_variant 1.759% (20/1137) 2 entries
ENSG00000148584 A1CF brain glioblastoma missense_variant 0.6479% (6/926) 2 entries
ENSG00000148584 A1CF skin melanoma sequence_alteration 5.791% (56/967) 5 entries
ENSG00000148584 A1CF basal cell carcinoma sequence_alteration 18.97% (11/58) 1 entry
ENSG00000148584 A1CF acute myeloid leukemia sequence_alteration 0.441% (4/907) 1 entry
ENSG00000148584 A1CF chronic lymphocytic leukemia sequence_alteration 1.014% (9/888) 1 entry
ENSG00000148584 A1CF hepatocellular carcinoma missense_variant 0.8889% (8/900) 1 entry
ENSG00000148584 A1CF squamous cell lung carcinoma sequence_alteration 1.575% (12/762) 2 entries
ENSG00000148584 A1CF esophageal squamous cell carcinoma sequence_alteration 0.8889% (6/675) 2 entries
ENSG00000148584 A1CF squamous cell lung carcinoma stop_gained 1.575% (12/762) 2 entries
ENSG00000148584 A1CF pancreatic ductal adenocarcinoma missense_variant 3.018% (38/1259) 1 entry
ENSG00000148584 A1CF skin melanoma missense_variant 5.791% (56/967) 6 entries
ENSG00000148584 A1CF melanoma missense_variant 7.921% (8/101) 2 entries
ENSG00000148584 A1CF prostate carcinoma missense_variant 2.582% (11/426) 3 entries
ENSG00000148584 A1CF colon adenocarcinoma missense_variant 0.561% (4/713) 1 entry
ENSG00000148584 A1CF clear cell renal carcinoma missense_variant 0.5696% (7/1229) 1 entry
ENSG00000148584 A1CF esophageal squamous cell carcinoma missense_variant 0.8889% (6/675) 2 entries
ENSG00000148584 A1CF colorectal adenocarcinoma stop_gained 1.759% (20/1137) 2 entries
ENSG00000148584 A1CF small cell lung carcinoma missense_variant 2.508% (8/319) 3 entries
ENSG00000148584 A1CF small cell lung carcinoma sequence_alteration 2.508% (8/319) 3 entries
ENSG00000148584 A1CF colorectal adenocarcinoma sequence_alteration 1.759% (20/1137) 1 entry
ENSG00000148584 A1CF squamous cell lung carcinoma missense_variant 1.575% (12/762) 1 entry
ENSG00000148584 A1CF prostate carcinoma sequence_alteration 2.582% (11/426) 1 entry
ENSG00000148584 A1CF lung adenocarcinoma missense_variant 1.634% (19/1163) 3 entries
ENSG00000148584 A1CF Endometrial Endometrioid Adenocarcinoma missense_variant 1.089% (6/551) 1 entry
ENSG00000148584 A1CF prostate adenocarcinoma missense_variant 5.021% (73/1454) 2 entries
ENSG00000148584 A1CF non-small cell lung carcinoma missense_variant 1.887% (1/53) 1 entry
ENSG00000148584 A1CF B-cell acute lymphoblastic leukemia missense_variant 1.852% (1/54) 1 entry
ENSG00000148584 A1CF female breast carcinoma missense_variant 0.3745% (1/267) 1 entry
ENSG00000148584 A1CF HER2 Positive Breast Carcinoma missense_variant 11.11% (12/108) 1 entry
ENSG00000148584 A1CF lung adenocarcinoma stop_gained 1.634% (19/1163) 1 entry
ENSG00000148584 A1CF basal cell carcinoma stop_gained 18.97% (11/58) 1 entry
ENSG00000148584 A1CF large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000148584 A1CF melanoma sequence_alteration 7.921% (8/101) 1 entry
ENSG00000148584 A1CF B-cell acute lymphoblastic leukemia sequence_alteration 1.852% (1/54) 1 entry
ENSG00000148584 A1CF angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000148584 A1CF bladder transitional cell carcinoma sequence_alteration 0.7299% (1/137) 1 entry
ENSG00000148584 A1CF Invasive Breast Carcinoma missense_variant 2.174% (1/46) 1 entry
ENSG00000148584 A1CF colorectal adenocarcinoma frameshift_variant 1.759% (20/1137) 1 entry
ENSG00000148584 A1CF diffuse large B-cell lymphoma missense_variant 0.6601% (2/303) 1 entry
ENSG00000148584 A1CF clear cell renal carcinoma sequence_alteration 0.5696% (7/1229) 1 entry
ENSG00000148584 A1CF melanoma stop_gained 7.921% (8/101) 1 entry
ENSG00000148584 A1CF diffuse gastric adenocarcinoma sequence_alteration 1.266% (1/79) 1 entry
ENSG00000148584 A1CF pulmonary blastoma missense_variant 4.167% (1/24) 1 entry
ENSG00000148584 A1CF ependymoma sequence_alteration 2.174% (1/46) 1 entry
ENSG00000148584 A1CF mucosal melanoma sequence_alteration 7.143% (1/14) 1 entry
ENSG00000148584 A1CF bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000148584 A1CF brain glioblastoma sequence_alteration 0.6479% (6/926) 1 entry
ENSG00000148584 A1CF mucosal melanoma missense_variant 7.143% (1/14) 1 entry
ENSG00000148584 A1CF gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000148584 A1CF Pancreatic Acinar Cell Carcinoma stop_gained 5.0% (1/20) 1 entry
ENSG00000148584 A1CF melanoma conservative_inframe_deletion 7.921% (8/101) 1 entry
ENSG00000148584 A1CF colorectal adenocarcinoma stop_lost 1.759% (20/1137) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000148584 A1CF MESO 0.029 high
ENSG00000148584 A1CF SARC 0.02 low
ENSG00000148584 A1CF STAD 0.037 high
ENSG00000148584 A1CF UVM 0.039 high
ENSG00000148584 A1CF PAAD 0.001 low
ENSG00000148584 A1CF UCEC 0.002 high
ENSG00000148584 A1CF THCA 0.031 high
ENSG00000148584 A1CF ACC 0.04 high
ENSG00000148584 A1CF LGG 0.0091 low
ENSG00000148584 A1CF LUSC 0.0061 high
ENSG00000148584 A1CF HNSC 0.0041 high
ENSG00000148584 A1CF LUAD 0.02 high
ENSG00000148584 A1CF PCPG 0.049 high
ENSG00000148584 A1CF THYM 0.0092 high
ENSG00000148584 A1CF BRCA 0.0081 high
ENSG00000148584 A1CF OV 0.015 high
ENSG00000148584 A1CF BLCA 0.0024 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000148584 A1CF GBM Del 2.643659 0.073553 0.693577 0.847487
ENSG00000148584 A1CF THCA Del 1.292832 0.011716 0.442653 0.022044