Ensembl ID
ENSG00000146701
Gene ID
4191
Accession
6971
Gene Symbol
MDH2
Alias
MDH;MOR1;DEE51;M-MDH;EIEE51;MGC:3559
Full Name
malate dehydrogenase 2
Position
7 : 76048051 - 76067508
Length
19458 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
ENSG00000146701 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000146701
MDH2
-0.5
2.95e-12
HNSC
ENSG00000146701
MDH2
0.48
4.19e-16
BRCA
ENSG00000146701
MDH2
1.05
7.90e-22
KICH
ENSG00000146701
MDH2
0.98
1.56e-36
LUSC
ENSG00000146701
MDH2
0.44
6.68e-11
PRAD
ENSG00000146701
MDH2
0.73
7.99e-11
UCEC
ENSG00000146701
MDH2
0.69
3.02e-17
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000146701
MDH2
prostate cancer
23389923
ENSG00000146701
MDH2
colorectal cancer
25356789
ENSG00000146701
MDH2
uterine cancer
25639359
ENSG00000146701
MDH2
tumors
25766404
ENSG00000146701
MDH2
cancer
26138106
ENSG00000146701
MDH2
cancer
27611801
ENSG00000146701
MDH2
cancer
27989324
ENSG00000146701
MDH2
tumor
28189066
ENSG00000146701
MDH2
Cancer
28332880
ENSG00000146701
MDH2
tumor
28423718
ENSG00000146701
MDH2
tumor
28819410
ENSG00000146701
MDH2
cancer
28991459
ENSG00000146701
MDH2
AML
29138577
ENSG00000146701
MDH2
neuroendocrine tumors
29144820
ENSG00000146701
MDH2
prostate cancer
29563510
ENSG00000146701
MDH2
cancer
30663084
ENSG00000146701
MDH2
prostate tumor
31495056
ENSG00000146701
MDH2
tumor
8917541
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000146701
MDH2
MESO
0.01
high
show
ENSG00000146701
MDH2
UVM
0.0012
high
show
ENSG00000146701
MDH2
UCEC
0.021
low
show
ENSG00000146701
MDH2
LGG
2e-04
high
show
ENSG00000146701
MDH2
KIRP
0.0044
low
show
ENSG00000146701
MDH2
LUAD
0.0042
high
show
ENSG00000146701
MDH2
BRCA
0.029
high
show
ENSG00000146701
MDH2
OV
0.023
high
show
ENSG00000146701
MDH2
DLBC
0.0015
low
show
ENSG00000146701
MDH2
KIRC
0.0066
low
show
ENSG00000146701
MDH2
LAML
0.0026
high
show
ENSG00000146701
MDH2
GBM
0.0021
high
show
ENSG00000146701
MDH2
SKCM
0.0074
high
show
ENSG00000146701
MDH2
LIHC
0.034
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
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