Ensembl ID ENSG00000146701 Gene ID 4191 Accession 6971
Gene Symbol MDH2 Alias MDH;MOR1;DEE51;M-MDH;EIEE51;MGC:3559 Full Name malate dehydrogenase 2
Position 7 : 76048051 - 76067508 Length 19458 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

ENSG00000146701 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000146701 -0.5 2.95e-12 HNSC
ENSG00000146701 0.48 4.19e-16 BRCA
ENSG00000146701 1.05 7.90e-22 KICH
ENSG00000146701 0.98 1.56e-36 LUSC
ENSG00000146701 0.44 6.68e-11 PRAD
ENSG00000146701 0.73 7.99e-11 UCEC
ENSG00000146701 0.69 3.02e-17 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000146701 prostate cancer 23389923
ENSG00000146701 colorectal cancer 25356789
ENSG00000146701 uterine cancer 25639359
ENSG00000146701 tumors 25766404
ENSG00000146701 cancer 26138106
ENSG00000146701 cancer 27611801
ENSG00000146701 cancer 27989324
ENSG00000146701 tumor 28189066
ENSG00000146701 Cancer 28332880
ENSG00000146701 tumor 28423718
ENSG00000146701 tumor 28819410
ENSG00000146701 cancer 28991459
ENSG00000146701 AML 29138577
ENSG00000146701 neuroendocrine tumors 29144820
ENSG00000146701 prostate cancer 29563510
ENSG00000146701 cancer 30663084
ENSG00000146701 prostate tumor 31495056
ENSG00000146701 tumor 8917541
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000146701 MESO 0.01 high
ENSG00000146701 UVM 0.0012 high
ENSG00000146701 UCEC 0.021 low
ENSG00000146701 LGG 2e-04 high
ENSG00000146701 KIRP 0.0044 low
ENSG00000146701 LUAD 0.0042 high
ENSG00000146701 BRCA 0.029 high
ENSG00000146701 OV 0.023 high
ENSG00000146701 DLBC 0.0015 low
ENSG00000146701 KIRC 0.0066 low
ENSG00000146701 LAML 0.0026 high
ENSG00000146701 GBM 0.0021 high
ENSG00000146701 SKCM 0.0074 high
ENSG00000146701 LIHC 0.034 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency